INT91754

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 42
Total Number 45
Disease Relevance 21.97
Pain Relevance 5.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cp) extracellular space (Cp) oxidoreductase activity (Cp)
extracellular region (Cp)
Anatomy Link Frequency
white matter 5
duct 2
microglia 2
blood vessels 2
astrocytes 2
Cp (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 153 100.00 Very High Very High Very High
Inflammation 529 99.48 Very High Very High Very High
chemokine 44 99.44 Very High Very High Very High
Arthritis 11 98.72 Very High Very High Very High
Pyramidal cell 6 95.28 Very High Very High Very High
cytokine 78 93.36 High High
Demyelination 56 93.32 High High
Central nervous system 246 92.60 High High
GABAergic 51 92.12 High High
Crohn's disease 4 91.84 High High
Disease Link Frequency Relevance Heat
Pancreatitis 190 100.00 Very High Very High Very High
Adenocarcinoma 177 100.00 Very High Very High Very High
Blast Crisis 8 100.00 Very High Very High Very High
Leukemia 8 100.00 Very High Very High Very High
Philadelphia Chromosome 3 100.00 Very High Very High Very High
Injury 178 99.82 Very High Very High Very High
Neurodegenerative Disease 42 99.80 Very High Very High Very High
INFLAMMATION 580 99.48 Very High Very High Very High
Myeloid Leukemia 38 99.44 Very High Very High Very High
Carcinoma In Situ 5 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, figure 6D shows that the four different probe sets used in the gene chip generated the same data, which all together provide very solid evidence that GR blockage is able to prevent LPS-induced Cp gene expression.
Gene_expression (expression) of Cp gene
1) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.21 Pain Relevance 0.04
Immunohistochemistry was combined with the in situ hybridization histochemistry protocol to determine the types of cells that express Cd44, Cd83, Cp, Lcn2, Saa3, Stat1 and Tnfsf9 transcripts.
Gene_expression (express) of Cp
2) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0 Pain Relevance 0
Since blood vessels are strategically positioned to produce Cp protein during systemic infection, we evaluated whether this APR modulates gene expression in vascular-associated elements during meningitis.
Gene_expression (produce) of Cp in blood vessels associated with meningitis and infection
3) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.89 Pain Relevance 0.16
We propose that Cp produced by microglial cells is released to the extracellular space for controlling iron homeostasis in this critical period, when white matter elements are more vulnerable.
Gene_expression (produced) of Cp in white matter
4) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.51 Pain Relevance 0.16
Quantification of in situ hybridization data indicated that RU486 significantly prevented LPS-induced Cp gene expression, but only at the higher dose tested (Fig. 5A, B).
Gene_expression (expression) of Cp gene
5) Confidence 0.77 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.25 Pain Relevance 0.05
Strikingly, expression of DMT1, FPN, ceruloplasmin (Cp), and hephaestin were higher in the choroid plexus on in situ hybridization than virtually all other brain regions (Figs. 3, 4, 5, 6 and 7).
Gene_expression (expression) of ceruloplasmin in choroid plexus
6) Confidence 0.75 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0 Pain Relevance 0.08
The cellular characterization of Cp: a candidate gene dependent on GR and LPS signaling
Gene_expression (characterization) of Cp
7) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.15 Pain Relevance 0
We found ceruloplasmin (Cp) that was strongly induced by LPS (neuroprotection) and completely inhibited by the GR blockade (a neurotoxic condition).
Gene_expression (found) of Cp
8) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.31 Pain Relevance 0.03
Double immunofluorescence staining was performed in sequential manner; primary antibody against Cp detection with Alexa488-conjugated goat anti-rabbit was followed by incubation of primary antibodies against CD31, GFAP, IBA1, or MAC-2 that were detected with immunoglobulin antibodies conjugated to Cy3.
Gene_expression (detection) of Cp
9) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.08 Pain Relevance 0.03
We found ceruloplasmin (Cp) that was strongly induced by LPS (neuroprotection) and completely inhibited by the GR blockade (a neurotoxic condition).
Gene_expression (found) of ceruloplasmin
10) Confidence 0.67 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.31 Pain Relevance 0.03
We analyzed expression patterns of iron transporters that were identified originally in the duodenal mucosa, including the apical transporter DMT1, the ferric reductase, Dcytb, the basolateral exporter ferroportin, and the membrane bound ferroxidase hephaestin.
Spec (analyzed) Gene_expression (expression) of ferroxidase
11) Confidence 0.65 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0 Pain Relevance 0.13
It is worth mentioning that the shape of MAC-2-positive cells was quite different from that of IBA1-positive microglia (Figure S4), suggesting the possibility that Cp is produced by the resident ramified microglia (IBA1) and not amoeboid-like or infiltrating myeloid cells (MAC-2).
Gene_expression (produced) of Cp in microglia
12) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.13 Pain Relevance 0.11
We also observed that Cp is highly expressed in cells lining the blood vessels.
Gene_expression (expressed) of Cp in blood vessels
13) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.54 Pain Relevance 0.11
MAC-2 is frequently used as a marker of a subtype of activated microglia, but it failed to express Cp (Fig. 5F).
Gene_expression (express) of Cp in microglia
14) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.11 Pain Relevance 0.09
19 for Cp+/- and -/-; n?
Gene_expression (/) of Cp
15) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.55 Pain Relevance 0.11
In 2000, 2001, and 2002, we responded to ad hoc, word-of-mouth expressions of interest in CP by individuals affiliated with resource centers and clinics in our region.
Gene_expression (expressions) of CP in mouth
16) Confidence 0.56 Published 2008 Journal Implement Sci Section Body Doc Link PMC2270865 Disease Relevance 0 Pain Relevance 0
Trainees revealed that they have expanded CP beyond the scope of training to include medical translators.
Gene_expression (expanded) of CP
17) Confidence 0.56 Published 2008 Journal Implement Sci Section Body Doc Link PMC2270865 Disease Relevance 0 Pain Relevance 0
In another study we demonstrated that the expression of ceruloplasmin (CP) is induced by a traumatic injury and that IL-1 is responsible for the injury-induced expression of CP in astrocytes [34].
Gene_expression (expression) of CP in astrocytes associated with injury
18) Confidence 0.24 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.99 Pain Relevance 0.20
CONCLUSION: BMB using a suprazygomatic approach seems to improve pain relief, to decrease peri-operative consumption of opioids, and to favor early feeding resumption after CP repair in infants.


Gene_expression (repair) of CP
19) Confidence 0.24 Published 2010 Journal Paediatr Anaesth Section Body Doc Link 20199610 Disease Relevance 0 Pain Relevance 0
, the expression of ceruloplasmin (CP) was analyzed.
Spec (analyzed) Gene_expression (expression) of CP
20) Confidence 0.21 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.51 Pain Relevance 0.03

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