INT91761

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 38
Total Number 38
Disease Relevance 22.93
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PSEN2) endoplasmic reticulum (PSEN2) embryo development (PSEN2)
protein complex (PSEN2) cytosol (PSEN2) peptidase activity (PSEN2)
Anatomy Link Frequency
coronary artery 1
MCF7 1
MCF-7 1
skin 1
fibroblasts 1
PSEN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 9 99.44 Very High Very High Very High
dexamethasone 364 96.96 Very High Very High Very High
Arthritis 3 96.72 Very High Very High Very High
Inflammation 268 96.60 Very High Very High Very High
bradykinin 225 95.00 High High
cINOD 50 94.84 High High
chemokine 4 93.56 High High
cytokine 39 92.96 High High
agonist 6 91.92 High High
Angina 4 86.48 High High
Disease Link Frequency Relevance Heat
Disease 702 100.00 Very High Very High Very High
Infection 111 100.00 Very High Very High Very High
Cancer 1062 99.88 Very High Very High Very High
Down Syndrome 48 99.68 Very High Very High Very High
Cervical Cancer 187 97.80 Very High Very High Very High
Inflammatory Breast Neoplasms 114 97.60 Very High Very High Very High
Apoptosis 267 97.56 Very High Very High Very High
Arthritis 3 96.72 Very High Very High Very High
INFLAMMATION 278 96.60 Very High Very High Very High
Alzheimer's Dementia 35 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 4B, transfection with adv-HO-1 (Adv, MOI = 10, 48 h) enhanced HO-1 expression and attenuated LPS-induced COX-2 expression.
Gene_expression (transfection) of Adv
1) Confidence 0.75 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0 Pain Relevance 0
Reagents were added 18 h prior the infection, and the infection with Ad5luc1, Adcox-2Mluc or AdVEGFluc, and incubation were performed in the presence of the substances.
Gene_expression (infection) of Ad5 associated with infection
2) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.74 Pain Relevance 0.13
Advanced subcutaneous C33A tumors were treated with three intratumoral injections of 1×109 vp of Ad5luc1, wild-type virus, Ad5/3VEGF-E1, RGDCRADcox-2R or Ad5-?
Gene_expression (/) of Ad5 associated with cancer
3) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.51 Pain Relevance 0.06
Tumor size was followed. 5/12 mice receiving intravenous Ad5/3VEGF-E1 treatment died within 12 h.
Gene_expression (receiving) of Ad5 associated with cancer
4) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 1.24 Pain Relevance 0.19
A similar but weaker effect was seen with Ad5/3VEGF-E1 (Fig. 5b: 1.5 to 3.5-fold, P?
Gene_expression (seen) of Ad5
5) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.53 Pain Relevance 0.33
Treatment with oncolytic viruses gave significant therapeutic efficacy in both models (Fig. 3e, f: P<0.0001 for RGDCRADcox-2R, Ad5/3VEGF-E1 or Ad5-?
Gene_expression (/) of Ad5
6) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.52 Pain Relevance 0.11
In efficacy experiment, mice were obtained from Charles River Laboratories (Wilmington, MA) and subcutaneous tumors were established by injecting 107 C33A cells into female nu/nu mice. 1×109 vp of Ad5luc1, wild-type, Ad5/3VEGF-E1, RGDCRADcox-2R, Ad5-?
Gene_expression (established) of Ad5 associated with cancer
7) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.57 Pain Relevance 0.14
Preparation of Ad5CMV, Ad5CMV-p53
Gene_expression (Preparation) of Ad5
8) Confidence 0.65 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.22 Pain Relevance 0
The cells were infected with Ad5CMV-p53 (5×108 vp), Ad5CMV (5×108 vp), or PBS as a control at days 1, 2, 3, 4, and 5 of incubation at 37?.
Gene_expression (infected) of Ad5
9) Confidence 0.65 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.16 Pain Relevance 0
Preparation of Ad5CMV, Ad5CMV-p53
Gene_expression (Preparation) of Ad5
10) Confidence 0.65 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 0.22 Pain Relevance 0
In addition to growth inhibition, tumor cells that were transfected with Ad5CMV-p53 had a markedly larger percentage of cells undergoing apoptosis than those transfected with Ad5CMV or PBS (p<0.001) (Fig. 5).
Gene_expression (transfected) of Ad5 associated with cancer and apoptosis
11) Confidence 0.65 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.07 Pain Relevance 0
After 2 and 4 weeks of treatment, the volume (cm3) of tumors in PBS, Ad5CMV, and Ad5CMV-p53 was as follows: 2 week: 1.66±0.43, 1.40±0.47, 0.75±0.26 (p<0.001), 4 week: 4.41±0.88, 3.93±1.86, 2.33±0.51 (p<0.001).
Gene_expression (was) of Ad5 associated with cancer
12) Confidence 0.65 Published 2004 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2816308 Disease Relevance 1.15 Pain Relevance 0
Advanced subcutaneous C33A tumors were treated with three intratumoral injections of 1×109 vp of Ad5luc1, wild-type virus, Ad5/3VEGF-E1, RGDCRADcox-2R or Ad5-?
Gene_expression (treated) of Ad5 associated with cancer
13) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.52 Pain Relevance 0.06
This review will focus on the interrelationships between the mechanisms of PS1, PS2 and betaAPP gene expression, tau and betaA deposition and the induction, regulation and proliferation in AD of the neuroinflammatory response.
Gene_expression (expression) of PS2 associated with disease
14) Confidence 0.61 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 0.98 Pain Relevance 0.23
Two trials have assessed the efficiency of an adenovirus expressing the 165 amino acid isoform of VEGF (VEGF-Adv) or of a plasmid expressing the same gene delivered in a liposome formulation (VEGF-P/L) injected intra-arterially after percutaneous transluminal angioplasty in patients with peripheral (Makinen et al 2002) and coronary artery disease (Hedman et al 2003) – the KAT trial.
Gene_expression (expressing) of Adv in coronary artery associated with coronary artery disease
15) Confidence 0.58 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.45 Pain Relevance 0.09
Another recombinant adenovirus vector in which p53-dependent expression of a fusion protein (E2F-Rb) selectively attenuated viral replication in normal cells, was further modified by insertion of the viral late promoter (MLP) in the E3 region with the aim of driving overexpression of Ad5-E3 11.6K protein, thereby increasing cytotoxicity in tumour cells, while decreasing cytotoxicity in normal cells.
Gene_expression (overexpression) of Ad5 associated with cancer
16) Confidence 0.58 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179760 Disease Relevance 0.84 Pain Relevance 0.03
Missense mutations in the presenilin genes PS1 and PS2, implicated in early onset familial AD, cause abnormal betaAPP processing with resultant overproduction of betaA42 and related neurotoxic peptides.
Gene_expression (overproduction) of PS2 associated with disease
17) Confidence 0.53 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 1.32 Pain Relevance 0.18
This review will focus on the interrelationships between the mechanisms of PS1, PS2 and betaAPP gene expression, tau and betaA deposition and the induction, regulation and proliferation in AD of the neuroinflammatory response.
Gene_expression (expression) of PS2 associated with disease
18) Confidence 0.53 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 0.98 Pain Relevance 0.23
All types of C-terminally truncated C100 variants including that lacking the entire cytoplasmic domain yielded the secreted form of Abeta at levels comparable with those from C100/WT, and co-transfection of mt PS2 increased the secretion of Abeta42.
Gene_expression (co-transfection) of PS2 associated with abeta
19) Confidence 0.52 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11283011 Disease Relevance 0.25 Pain Relevance 0.13
C100/TGN co-transfected with mt PS2 increased levels or ratios of intracellular as well as secreted Abeta42 at similar levels to those with C100 without signals (C100/WT), whereas C100/ER yielded a negligible level of Abeta, which was not affected by co-transfection of mt PS2.
Neg (not) Gene_expression (co-transfection) of PS2 associated with abeta
20) Confidence 0.45 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11283011 Disease Relevance 0.30 Pain Relevance 0.12

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