INT91762

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Context Info
Confidence 0.17
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.45
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLA2G1B) extracellular space (PLA2G1B) extracellular region (PLA2G1B)
Anatomy Link Frequency
endothelial cells 2
brain 2
PLA2G1B (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 2 99.32 Very High Very High Very High
Inflammation 59 91.68 High High
chemokine 1 83.80 Quite High
iatrogenic 2 83.28 Quite High
cytokine 4 83.20 Quite High
Inflammatory response 3 76.32 Quite High
corticosteroid 9 74.60 Quite High
cINOD 81 72.48 Quite High
Arthritis 1 54.40 Quite High
acular 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 4 99.68 Very High Very High Very High
Injury 13 98.80 Very High Very High Very High
Epilepsy 1 98.48 Very High Very High Very High
Disease 14 97.96 Very High Very High Very High
Brain Injury 1 94.80 High High
Adult Respiratory Distress Syndrome 28 91.84 High High
INFLAMMATION 62 91.68 High High
Apoptosis 2 86.88 High High
Autoimmune Disease 1 86.84 High High
Lung Injury 16 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the inducible oxidoreductase cyclooxygenase-2 and cytosolic phospholipase A2 (cPLA2) are strongly activated during cerebral ischemia and trauma, epilepsy and AD, indicating the induction of proinflammatory gene pathways as a response to brain injury.
Positive_regulation (activated) of Gene_expression (Expression) of phospholipase A2 in brain associated with epilepsy, cv general 4 under development, ischemia, injury, disease and brain injury
1) Confidence 0.17 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 1.43 Pain Relevance 0.26
Moreover, in vitro studies have revealed that APC causes a dose-dependent inhibition of interferon-induced expression of phospholipase A2 [45] and upregulation of cyclooxygenase II expression in endothelial cells [46].
Positive_regulation (induced) of Gene_expression (expression) of phospholipase A2 in endothelial cells
2) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2646309 Disease Relevance 1.01 Pain Relevance 0.17
Eicosanoids are defined as prostaglandins, leukotrienes, and other compounds that are products of the action of phospholipase A2 on the cellular phospholipid membrane and are, in general, derived from the production of arachidonic acid (Figure 1).
Positive_regulation (derived) of Gene_expression (products) of phospholipase A2
3) Confidence 0.05 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693998 Disease Relevance 1.00 Pain Relevance 0.54

General Comments

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