INT91765

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.57
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PSEN2) endoplasmic reticulum (PSEN2) embryo development (PSEN2)
protein complex (PSEN2) cytosol (PSEN2) peptidase activity (PSEN2)
PSEN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 9 99.44 Very High Very High Very High
chemokine 1 93.56 High High
cytokine 4 92.96 High High
Inflammatory response 3 86.08 High High
ischemia 1 78.00 Quite High
depression 1 63.16 Quite High
Pain 2 61.88 Quite High
cINOD 9 38.64 Quite Low
Arthritis 1 33.76 Quite Low
Inflammation 22 32.24 Quite Low
Disease Link Frequency Relevance Heat
Disease 27 100.00 Very High Very High Very High
Cancer 102 99.66 Very High Very High Very High
Apoptosis 39 97.56 Very High Very High Very High
INFLAMMATION 21 85.72 High High
Breast Cancer 53 81.48 Quite High
Cv General 4 Under Development 1 78.72 Quite High
Infection 9 78.56 Quite High
Alzheimer's Dementia 12 78.00 Quite High
Reprotox - General 3 2 77.64 Quite High
Amyloid Plaque 1 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to growth inhibition, tumor cells that were transfected with Ad5CMV-p53 had a markedly larger percentage of cells undergoing apoptosis than those transfected with Ad5CMV or PBS (p<0.001) (Fig. 5).
Positive_regulation (transfected) of Gene_expression (transfected) of Ad5 associated with cancer and apoptosis
1) Confidence 0.49 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.07 Pain Relevance 0
As shown in Figure 4B, transfection with adv-HO-1 (Adv, MOI = 10, 48 h) enhanced HO-1 expression and attenuated LPS-induced COX-2 expression.
Positive_regulation (transfection) of Gene_expression (transfection) of Adv
2) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0 Pain Relevance 0
Missense mutations in the presenilin genes PS1 and PS2, implicated in early onset familial AD, cause abnormal betaAPP processing with resultant overproduction of betaA42 and related neurotoxic peptides.
Positive_regulation (overproduction) of Gene_expression (overproduction) of PS2 associated with disease
3) Confidence 0.40 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 1.32 Pain Relevance 0.18
All types of C-terminally truncated C100 variants including that lacking the entire cytoplasmic domain yielded the secreted form of Abeta at levels comparable with those from C100/WT, and co-transfection of mt PS2 increased the secretion of Abeta42.
Positive_regulation (co-transfection) of Gene_expression (co-transfection) of PS2 associated with abeta
4) Confidence 0.33 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11283011 Disease Relevance 0.25 Pain Relevance 0.13
C100/TGN co-transfected with mt PS2 increased levels or ratios of intracellular as well as secreted Abeta42 at similar levels to those with C100 without signals (C100/WT), whereas C100/ER yielded a negligible level of Abeta, which was not affected by co-transfection of mt PS2.
Positive_regulation (co-transfection) of Neg (not) Gene_expression (co-transfection) of PS2 associated with abeta
5) Confidence 0.33 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11283011 Disease Relevance 0.30 Pain Relevance 0.12
Tumour growth was significantly enhanced in mice simultaneously exposed to tamoxifen and genistein, whereas levels of pS2 and cyclin D1 expression were increased.
Positive_regulation (increased) of Gene_expression (expression) of pS2 associated with cancer
6) Confidence 0.33 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.87 Pain Relevance 0.09
C100/TGN co-transfected with mt PS2 increased levels or ratios of intracellular as well as secreted Abeta42 at similar levels to those with C100 without signals (C100/WT), whereas C100/ER yielded a negligible level of Abeta, which was not affected by co-transfection of mt PS2.
Positive_regulation (co-transfected) of Gene_expression (co-transfected) of PS2 associated with abeta
7) Confidence 0.29 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11283011 Disease Relevance 0.33 Pain Relevance 0.11
PS1 and PS2 FAD mutants have been shown to increase the ratio of A?
Positive_regulation (increase) of Gene_expression (mutants) of PS2 associated with disease
8) Confidence 0.18 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.44 Pain Relevance 0

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