INT91771

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.93
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PSEN1) Golgi apparatus (PSEN1) endoplasmic reticulum (PSEN1)
embryo development (PSEN1) peptidase activity (PSEN1) cell death (PSEN1)
Anatomy Link Frequency
fibroblasts 8
IMR-32 2
PSEN1 (Homo sapiens)
PSEN1 - M146L (3)
Pain Link Frequency Relevance Heat
bradykinin 300 99.70 Very High Very High Very High
chemokine 1 93.88 High High
cytokine 4 93.28 High High
Potency 14 88.72 High High
Inflammatory response 3 86.40 High High
ischemia 6 78.00 Quite High
cINOD 60 77.36 Quite High
Arthritis 1 33.76 Quite Low
Inflammation 92 25.00 Low Low
aspirin 21 13.28 Low Low
Disease Link Frequency Relevance Heat
Disease 999 100.00 Very High Very High Very High
Stress 434 99.18 Very High Very High Very High
Neuroblastoma 15 98.64 Very High Very High Very High
Down Syndrome 64 93.08 High High
Hypercholesterolemia 3 89.96 High High
Hypertension 5 88.96 High High
Cardiovascular Disease 8 88.40 High High
INFLAMMATION 95 86.04 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 14 85.96 High High
Increased Venous Pressure Under Development 5 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
42 overproduction with FAD argues strongly in favor of a critical role for A?
Positive_regulation (overproduction) of Gene_expression (overproduction) of FAD
1) Confidence 0.49 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.59 Pain Relevance 0
Thus H2O2-induced oxidative stress resulted in early lagging ERK and later enhanced JNK activation in the PS-1 (M146L) AD fibroblasts.
Positive_regulation (enhanced) of Gene_expression (activation) of PS-1 (M146L) in fibroblasts associated with stress and disease
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.53 Pain Relevance 0
Gamma-secretase inhibitor Compound E restores normal BK-dependent ERK activation in PS-1 (M146L) AD fibroblasts
Positive_regulation (activation) of Gene_expression (fibroblasts) of PS-1 (M146L) in fibroblasts associated with disease and bradykinin
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.97 Pain Relevance 0.48
Quantitation of the relative fluorescence intensity of caspase activation revealed a significant 8–10 fold enhancement of caspase-3 activity in the PS-1 (M146L) AD fibroblasts between 2 and 7 hr after oxidative stress (Figure 12L).
Positive_regulation (enhancement) of Gene_expression (activity) of PS-1 (M146L) in fibroblasts associated with stress and disease
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.42 Pain Relevance 0
While mutant PS1 carrying a single DTG triplet at D257 (PS1-D257TG) behaved similar to wt PS1, mutant PS1 carrying a single DGT triplet at D385 (PS1-D385TG) caused a remarkably increased production of A?
Positive_regulation (mutant) of Gene_expression (carrying) of PS1-D257TG
5) Confidence 0.41 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.11 Pain Relevance 0
Transient transfection of these PS1 mutant constructs into the human IMR-32 neuroblastoma cells or a mouse neuroblastoma cell line N2A-APP, which expresses human Swedish APP as previously described [42,43], also produced similar patterns of A?
Positive_regulation (transfection) of Gene_expression (transfection) of PS1 mutant in IMR-32 associated with neuroblastoma
6) Confidence 0.41 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.20 Pain Relevance 0
, caused by the PS1 mutants harboring the DTG triplet were explored by treating transfected cells with two well characterized ?
Positive_regulation (caused) of Gene_expression (mutants) of PS1
7) Confidence 0.41 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.18 Pain Relevance 0
42, fenchylamine sulfonamide produced a large stimulus response on cells expressing endogenous PS1 or transfected wt PS1, but had a weak stimulating effect or no inhibition on the other cell lines (Figure 3B).
Positive_regulation (transfected) of Gene_expression (transfected) of PS1
8) Confidence 0.41 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.13 Pain Relevance 0.27
PS1 and PS2 FAD mutants have been shown to increase the ratio of A?
Positive_regulation (increase) of Gene_expression (mutants) of PS1 associated with disease
9) Confidence 0.41 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.44 Pain Relevance 0
Missense mutations in the presenilin genes PS1 and PS2, implicated in early onset familial AD, cause abnormal betaAPP processing with resultant overproduction of betaA42 and related neurotoxic peptides.
Positive_regulation (overproduction) of Gene_expression (overproduction) of PS1 associated with disease
10) Confidence 0.39 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059791 Disease Relevance 1.33 Pain Relevance 0.18
PS-1 M146L AD has one of the earlier ages of onset among PS-1 mutations, occurring below age 40, and skin fibroblasts from such individuals elaborate a 9-fold greater amount of A?
Positive_regulation (occurring) of Gene_expression (mutations) of PS-1 in fibroblasts associated with disease
11) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.49 Pain Relevance 0
PS1 and PS2 FAD mutants have been shown to increase the ratio of A?
Positive_regulation (increase) of Gene_expression (mutants) of FAD associated with disease
12) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.44 Pain Relevance 0
While mutant PS1 carrying a single DTG triplet at D257 (PS1-D257TG) behaved similar to wt PS1, mutant PS1 carrying a single DGT triplet at D385 (PS1-D385TG) caused a remarkably increased production of A?
Positive_regulation (mutant) of Gene_expression (carrying) of PS1
13) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.11 Pain Relevance 0

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