INT91772

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 115
Total Number 115
Disease Relevance 38.12
Pain Relevance 8.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PSEN1) Golgi apparatus (PSEN1) endoplasmic reticulum (PSEN1)
embryo development (PSEN1) peptidase activity (PSEN1) cell death (PSEN1)
Anatomy Link Frequency
fibroblasts 8
cleavage 4
oocyte 3
zona pellucida 2
germ cells 2
PSEN1 (Homo sapiens)
PSEN1 - M146V (9) PSEN1 - M146L (4)
Pain Link Frequency Relevance Heat
cINOD 563 100.00 Very High Very High Very High
Inflammation 466 100.00 Very High Very High Very High
Hippocampus 135 99.84 Very High Very High Very High
bradykinin 900 99.42 Very High Very High Very High
Central nervous system 181 97.56 Very High Very High Very High
Arthritis 3 97.48 Very High Very High Very High
Potency 128 95.68 Very High Very High Very High
chemokine 44 93.88 High High
Eae 59 93.84 High High
cytokine 144 93.28 High High
Disease Link Frequency Relevance Heat
Disease 4171 100.00 Very High Very High Very High
Alzheimer's Dementia 1197 100.00 Very High Very High Very High
Targeted Disruption 886 100.00 Very High Very High Very High
INFLAMMATION 508 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 21 99.68 Very High Very High Very High
Urological Neuroanatomy 20 99.68 Very High Very High Very High
Down Syndrome 236 99.36 Very High Very High Very High
Stress 1404 98.92 Very High Very High Very High
Ovarian Cancer 36 98.80 Very High Very High Very High
Neuroblastoma 138 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice with conditional ablation of PS1 and expression of FAD-associated human PS variants have provided some clues about the physiological consequences and stages in the development of disease.
Gene_expression (expression) of FAD associated with targeted disruption and disease
1) Confidence 0.75 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.82 Pain Relevance 0.06
Similar neuroinflammatory changes have been observed in other murine models of AD, including the APP/PS1 double transgenic and APP/PS1/Tau triple transgenic (3xTg-AD) mice [115-117].
Gene_expression (transgenic) of PS1 associated with targeted disruption and alzheimer's dementia
2) Confidence 0.65 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.44 Pain Relevance 0.40
42 is constitutively produced in the brain, mutations in the APP or PS1/2 genes (which alter the cleavage specificity of ?
Gene_expression (mutations) of PS1 in cleavage
3) Confidence 0.65 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.41 Pain Relevance 0.08
Moreover, among the other mechanisms triggering cell death and described in paragraph 4, we must acknowledge also the genetic mutations (APP, PS1/2, APOE) that cause an alteration of APP processing and accumulation of neurotoxic A?
Gene_expression (/) of PS1 associated with death
4) Confidence 0.65 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.49 Pain Relevance 0.08
The mechanism of FAD-associated PS variants in elevating levels of A?
Gene_expression (mechanism) of FAD associated with disease
5) Confidence 0.65 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.32 Pain Relevance 0.09
In APP Tg mice (PSAPP line = TG2576 × PS1M146V), dietary cholesterol seems to accelerate A?
Gene_expression (line) of PS1 associated with targeted disruption and disorder of lipid metabolism
6) Confidence 0.65 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.67 Pain Relevance 0.10
was chronically overexpressed in the hippocampus of APP/PS1 transgenic animals, we witnessed a surprising reduction in both plaque pathology and insoluble amyloid peptide without evidence of effects on A?
Gene_expression (animals) of PS1 in plaque associated with targeted disruption, alzheimer's dementia and hippocampus
7) Confidence 0.65 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.89 Pain Relevance 0.12
The Tg2576 mouse shows a significant elevation in the density of cholinergic synapses in the frontal and parietal cortices, but in the double transgenic Tg2576 × PS1M146L the density of cholinergic synapses is significantly reduced in the frontal cortex.
Gene_expression (reduced) of PS1 in synapses associated with targeted disruption and urological neuroanatomy
8) Confidence 0.65 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.76 Pain Relevance 0.11
A triple-transgenic model of AD (3xTg-AD) has recently been created that harbors three disease-relevant genetic alterations: a human Presenilin M146V knock-in mutation (PS1M146V), human amyloid precursor protein Swedish mutation (APPswe), and the human tauP301L mutation.
Gene_expression (mutation) of PS1 (M146V) associated with targeted disruption, alzheimer's dementia and disease
9) Confidence 0.65 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 1.95 Pain Relevance 0.29
Down’s syndrome (DS) patients, who are trisomic for chromosome 21 and thus have an extra copy of the APP gene, and FAD families with a duplicated APP gene locus [4] exhibit total A?
Gene_expression (families) of FAD associated with syndrome and generaliased trisomy
10) Confidence 0.65 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.41 Pain Relevance 0
Substitutions of larger hydrophobic amino acids (such as Leu found in the Swedish FAD mutation) for the Met residue at P1 improve the efficiency of ?
Gene_expression (mutation) of FAD
11) Confidence 0.65 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.06 Pain Relevance 0
42 overproduction with FAD argues strongly in favor of a critical role for A?
Gene_expression (overproduction) of FAD
12) Confidence 0.65 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.59 Pain Relevance 0
The skin fibroblasts employed here express PS-1 and PS-2 in their normal or mutated forms at natural endogenous levels, obviating the issue of quantitative effects frequently present in other types of expression systems.
Gene_expression (express) of PS-1 in skin
13) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.59 Pain Relevance 0.06
Comparing stimulus-specific cascades of signal transduction revealed a striking diversity of molecular signaling profiles in AD human skin fibroblasts that express endogenous levels of mutant presenilins PS-1 or PS-2 or the Trisomy 21 proteome.
Gene_expression (express) of PS-1 in fibroblasts associated with down syndrome and disease
14) Confidence 0.64 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2644820 Disease Relevance 1.75 Pain Relevance 0.18
, APD3 (expressing both Swedish APP and PS1-M146V, ?)
Gene_expression (expressing) of PS1-M146V (M146V)
15) Confidence 0.63 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.15 Pain Relevance 0
The cell line APE12, expressing both Swedish APP and PS1-D257TG, showed a similar biphasic curve but in a lower dose range (0.1 ?
Gene_expression (expressing) of PS1-D257TG
16) Confidence 0.63 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.13 Pain Relevance 0
species under the treated conditions, media from the three tested cell lines expressing PS1, PS1-D385TG and PS1-M146V were collected, and A?
Gene_expression (expressing) of PS1-M146V (M146V)
17) Confidence 0.63 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0.43
A similar pro</span>cedure was followed for the establishment of 125.3-16 cells that express PS1, PS1-D385TG, PS1-D257TG/D385TG, PS1-M146V, or PS1-D257TG cDNA inserts.
Gene_expression (express) of PS1-M146V (M146V)
18) Confidence 0.63 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0
Cells expressing PS1-D257TG (APE12) were also more sensitive to the drug treatment with 3 ?
Gene_expression (expressing) of PS1-D257TG
19) Confidence 0.63 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.17 Pain Relevance 0.04
42 secretion in a dose dependent manner in APB10 cell line expressing both Swedish APP and PS1-D385TG or APD cell line expressing both Swedish APP and the clinical mutation of PS1 M146V (Table 4).
Gene_expression (expressing) of PS1-D385TG
20) Confidence 0.63 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0.51

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