INT91774

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 16.14
Pain Relevance 10.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr3c1) nucleus (Nr3c1) intracellular (Nr3c1)
DNA binding (Nr3c1) protein complex (Nr3c1) transcription factor binding (Nr3c1)
Anatomy Link Frequency
pituitary 3
brain 2
plasma 1
dorsal 1
liver 1
Nr3c1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 21 100.00 Very High Very High Very High
Morphine 172 99.92 Very High Very High Very High
Spinal cord 5 99.88 Very High Very High Very High
fluoxetine 39 99.78 Very High Very High Very High
antidepressant 52 99.72 Very High Very High Very High
tricyclic antidepressant 25 99.60 Very High Very High Very High
amygdala 35 98.92 Very High Very High Very High
Inflammation 111 98.74 Very High Very High Very High
Hippocampus 44 98.74 Very High Very High Very High
Thermal hyperalgesia 2 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 87 99.88 Very High Very High Very High
Spinal Cord Injury 1 99.88 Very High Very High Very High
Chronic Fatigue Syndrome 167 99.62 Very High Very High Very High
INFLAMMATION 152 98.74 Very High Very High Very High
Hyperalgesia 3 98.64 Very High Very High Very High
Stress 172 97.98 Very High Very High Very High
Acromegaly 4 97.92 Very High Very High Very High
Neuropathic Pain 7 97.64 Very High Very High Very High
Nicotine Addiction 149 97.32 Very High Very High Very High
Depression 103 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the injured spinal cord, the expression of glucocorticoid receptor mRNA was increased, whereas it was decreased in N-type Ca(2+)-channel-deficient mice, in which neuropathic pain is eliminated.
Gene_expression (expression) of glucocorticoid receptor mRNA in spinal cord associated with spinal cord injury, neuropathic pain and spinal cord
1) Confidence 0.78 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16256102 Disease Relevance 0.91 Pain Relevance 1.04
Transgenic mice bearing a transgene coding for a glucocorticoid receptor antisense mRNA that partially blocks glucocorticoid receptor expression were used to investigate the long-term effect of hypothalamic-pituitary-adrenal dysfunction on brain 5-hydroxytryptamine-2A (5-HT2A) receptor expression.
Gene_expression (expression) of glucocorticoid receptor in brain associated with targeted disruption
2) Confidence 0.77 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11174015 Disease Relevance 0.39 Pain Relevance 0.13
They consisted of knock-out mice lacking the 5-HT transporter (5-HTT-/-) and of transgenic mice with impaired glucocorticoid receptor (GR-i) expression.
Gene_expression (expression) of glucocorticoid receptor associated with targeted disruption
3) Confidence 0.72 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059794 Disease Relevance 0.53 Pain Relevance 0.17
Transgenic mice bearing a transgene coding for a glucocorticoid receptor antisense mRNA, which partially blocks glucocorticoid receptor expression, were used to investigate the long-term effect of hypothalamic-pituitary-adrenal axis dysfunction on brain dopamine transmission.
Gene_expression (expression) of glucocorticoid receptor in brain associated with targeted disruption and dopamine
4) Confidence 0.50 Published 2001 Journal Neuroscience Section Abstract Doc Link 11226678 Disease Relevance 0.32 Pain Relevance 0.23
We considered 36 autosomal SNPs that the CDC had selected from eight candidate CFS genes, TPH2 (SNPs selected from locus 12q21), POMC (2p24), NR3C1 (5q34), CRHR2 (7p15), TH (11p15), SLC6A4 (17q11.1), CRHR1 (17q21), COMT (22q11.1) [38].
Gene_expression (selected) of NR3C1 associated with chronic fatigue syndrome
5) Confidence 0.37 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 0.19 Pain Relevance 0
Subclasses of CFS have been associated with polymorphisms in genes that function in the HPA axis NR3C1, TPH2 and MAOA [37-39].
Gene_expression (axis) of NR3C1 associated with chronic fatigue syndrome
6) Confidence 0.37 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2625353 Disease Relevance 1.28 Pain Relevance 0.24
Levels of corticotropin-releasing hormone mRNA expression in the hypothalamus and proopiomelanocortin mRNA expression in the pituitary were significantly increased, and glucocorticoid receptor protein expression in the hypothalamus paraventricular nucleus was downregulated in the depression-like model mice.
Gene_expression (expression) of glucocorticoid receptor protein in hypothalamus associated with depression
7) Confidence 0.33 Published 2006 Journal Phytomedicine Section Abstract Doc Link 16516452 Disease Relevance 1.02 Pain Relevance 0.50
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Gene_expression (expression) of glucocorticoid receptor in cortex associated with locus ceruleus, amygdala and fluoxetine
8) Confidence 0.31 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.10
Widespread hypothalamic-pituitary-adrenocortical axis-relevant and mood-relevant effects of chronic fluoxetine treatment on glucocorticoid receptor gene expression in mice.
Gene_expression (expression) of glucocorticoid receptor in pituitary associated with fluoxetine
9) Confidence 0.31 Published 2010 Journal Eur. J. Neurosci. Section Title Doc Link 20374287 Disease Relevance 0.58 Pain Relevance 0.82
Expression of glucocorticoid receptor and early growth response gene 1 during postnatal development of two inbred strains of mice exposed to early life stress.
Gene_expression (Expression) of glucocorticoid receptor associated with stress and sprains and strains
10) Confidence 0.24 Published 2010 Journal Dev. Neurosci. Section Title Doc Link 20453467 Disease Relevance 0.92 Pain Relevance 0.04
We cannot exclude the possibility that either we failed to observe the expected phenotype due to an absence of effects or that compensatory mechanisms other than glucocorticoid receptor expression (e.g. hypothalamic CRF levels, adrenal sensitivity to ACTH etc.) may have leveled-out the expected differences.
Gene_expression (expression) of glucocorticoid receptor
11) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2000350 Disease Relevance 0.26 Pain Relevance 0.03
At a molecular level, these effects are most likely mediated via an increase in glucocorticoid receptor gene expression [11], [20], [21] and/or an increase in GABA-A and central benzodiazepine receptor levels [22].
Gene_expression (expression) of glucocorticoid receptor associated with gaba
12) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2000350 Disease Relevance 0.53 Pain Relevance 0.05
Modulation of behavioral effects of morphine by glucocorticoid receptor blockade
Gene_expression (blockade) of glucocorticoid receptor associated with morphine
13) Confidence 0.21 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.18 Pain Relevance 0.98
Conversely, blocking the action of endogenous anti-inflammatory molecules, such as glucocorticoid hormones in transgenic mice expressing a glucocorticoid receptor (GR) antisense RNA, sharply increases microglial activation in response to MPTP, resulting in increased DAergic neuron vulnerability [8,10,11].
Gene_expression (expressing) of glucocorticoid receptor in neuron associated with parkinson's disease, targeted disruption and inflammation
14) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.51 Pain Relevance 0.60
Although the expressional changes were weak, duodenal expressions of glucocorticoid receptor (GR), the vitamin D receptor (VDR), and renal expressions of the parathyroid hormone receptor (PTHR) and VDR were increased following 24 h treatment with Dex.
Gene_expression (expressions) of glucocorticoid receptor in parathyroid
15) Confidence 0.15 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
A high level of 5-HT in the hippocampus was shown to increase nerve growth factor1-A level and induce glucocorticoid receptor gene expression during development, which alters animals' adaptation to stress in adulthood[40].
Gene_expression ( gene expr) of glucocorticoid receptor in nerve associated with stress and hippocampus
16) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0.16 Pain Relevance 0.14
Moreover, this stress exposure paradigm caused a rise in basal plasma corticosterone levels, paralleled with an increased expression of the glucocorticoid receptor (GR) and corticotropin-releasing factor (CRF) receptor 1 [78].
Gene_expression (expression) of glucocorticoid receptor in plasma associated with stress
17) Confidence 0.12 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 1.59 Pain Relevance 0.23
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Gene_expression (expression) of glucocorticoid receptor in locus coeruleus associated with locus ceruleus, amygdala and fluoxetine
18) Confidence 0.11 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.10
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Gene_expression (expression) of glucocorticoid receptor in dorsal associated with locus ceruleus, amygdala and fluoxetine
19) Confidence 0.11 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.10
Fluoxetine decreased glucocorticoid receptor (GR) gene expression in the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé nucleus, and increased locus coeruleus tyrosine hydroxylase and dorsal raphé nucleus tryptophan hydroxylase-2 (TPH2) gene expression.
Gene_expression (expression) of glucocorticoid receptor in amygdala associated with locus ceruleus, amygdala and fluoxetine
20) Confidence 0.11 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.50 Pain Relevance 1.10

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