INT91775

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2011
Negated 4
Speculated 1
Reported most in Abstract
Documents 102
Total Number 109
Disease Relevance 26.45
Pain Relevance 28.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
neurons 9
retina 7
eye 7
brain 6
5-HT neurons 5
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 1884 100.00 Very High Very High Very High
fluoxetine 1134 100.00 Very High Very High Very High
monoamine 186 100.00 Very High Very High Very High
Neurotransmitter 104 100.00 Very High Very High Very High
Raphe 410 99.68 Very High Very High Very High
Dopamine 305 99.56 Very High Very High Very High
sSRI 482 99.48 Very High Very High Very High
antagonist 62 99.32 Very High Very High Very High
antidepressant 295 99.28 Very High Very High Very High
Inflammation 358 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 289 100.00 Very High Very High Very High
Autism 13 99.60 Very High Very High Very High
Infection 19 99.38 Very High Very High Very High
Colitis 197 99.12 Very High Very High Very High
Inflammatory Bowel Disease 297 99.08 Very High Very High Very High
Hypoxia 12 98.96 Very High Very High Very High
Anxiety Disorder 129 98.80 Very High Very High Very High
INFLAMMATION 346 98.76 Very High Very High Very High
Hypertension 31 98.64 Very High Very High Very High
Catalepsy 18 98.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data were supported by ELISA assays, which showed enhanced 5-HT release during colitis, by immunohistochemical analyses, which showed increases in EC cell numbers, and by real-time PCR, which identified a decrease in SERT mRNA expression in the mucosa during colitis.
Gene_expression (expression) of SERT mRNA associated with colitis
1) Confidence 0.78 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20019165 Disease Relevance 0.65 Pain Relevance 0.27
These results demonstrate that reduced SERT function (via pharmacological blockade) significantly alters GI motility and sensitivity in mice, and support the concept that altered SERT expression and function could contribute to symptoms associated with IBS and IBD.
Gene_expression (expression) of SERT associated with inflammatory bowel disease and spastic colon
2) Confidence 0.78 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16700726 Disease Relevance 0.43 Pain Relevance 0.38
Peritoneal macrophages express the serotonin transporter.
Gene_expression (express) of serotonin transporter in Peritoneal macrophages associated with serotonin
3) Confidence 0.78 Published 2005 Journal J. Neuroimmunol. Section Title Doc Link 15652409 Disease Relevance 0 Pain Relevance 0.34
Macrophage activation with lipopolysaccharide had no effect on expression of SERT mRNA or protein.
Gene_expression (expression) of SERT mRNA in Macrophage
4) Confidence 0.78 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15652409 Disease Relevance 0 Pain Relevance 0.34
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Gene_expression (production) of SLC6A4 in oocytes
5) Confidence 0.76 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.14
No effect on cortical 5-HT1A and 5-HT2A receptor mRNA levels and on 5-HT1A receptor, tph2 (tryptophan hydroxylase-2) and SERT (serotonin transporter) mesencephalic gene expression was observed in ASC mice.
Gene_expression (expression) of SERT associated with serotonin
6) Confidence 0.75 Published 2009 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 19445393 Disease Relevance 0.71 Pain Relevance 0.55
No effect on cortical 5-HT1A and 5-HT2A receptor mRNA levels and on 5-HT1A receptor, tph2 (tryptophan hydroxylase-2) and SERT (serotonin transporter) mesencephalic gene expression was observed in ASC mice.
Gene_expression (expression) of serotonin transporter associated with serotonin
7) Confidence 0.75 Published 2009 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 19445393 Disease Relevance 0.71 Pain Relevance 0.54
We found increased expression of 5-HTT in RANKL-induced osteoclast-like cells.
Gene_expression (expression) of 5-HTT in osteoclast associated with fluoxetine
8) Confidence 0.75 Published 2004 Journal J. Bone Miner. Res. Section Abstract Doc Link 15312242 Disease Relevance 0 Pain Relevance 0.18
Mucosal SERT and tryptophan hydroxylase-1 expression are decreased in experimental inflammation, IBS-C, IBS-D, and ulcerative colitis.
Gene_expression (expression) of SERT associated with inflammatory bowel disease and inflammation
9) Confidence 0.74 Published 2005 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 15798484 Disease Relevance 1.01 Pain Relevance 0.43
We found that the level of central 5-HT in Lmx1b iCKO mice is reduced to 60% of controls, and that the expression of 5-HT neuron-associated genes such as Tph2, Sert and Vmat2 are down-regulated in Lmx1b iCKO mice.
Gene_expression (expression) of Sert in 5-HT neuron
10) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.31
Expression of serotonin (5-hydroxytryptamine; 5-HT), 5-HT receptors 1A (5-HT1AR) and 2A, and serotonin transporter protein (SERT) was studied in positive epicutaneous reactions to nickel sulphate in nickel-allergic patients, at 72 h post-challenge with the antigen.
Gene_expression (Expression) of serotonin transporter protein associated with hypersensitivity and serotonin
11) Confidence 0.69 Published 2007 Journal Acta Derm. Venereol. Section Abstract Doc Link 17721644 Disease Relevance 0.24 Pain Relevance 0.35
Expression of serotonin (5-hydroxytryptamine; 5-HT), 5-HT receptors 1A (5-HT1AR) and 2A, and serotonin transporter protein (SERT) was studied in positive epicutaneous reactions to nickel sulphate in nickel-allergic patients, at 72 h post-challenge with the antigen.
Gene_expression (Expression) of SERT associated with hypersensitivity and serotonin
12) Confidence 0.69 Published 2007 Journal Acta Derm. Venereol. Section Abstract Doc Link 17721644 Disease Relevance 0.24 Pain Relevance 0.36
Serotonin-selective reuptake transporter (SERT) expression is decreased in animal models of intestinal inflammation and in individuals with inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS), and it is possible that resultant changes in intestinal serotonin signalling contribute to the manifestation of clinical features associated with these disorders.
Gene_expression (expression) of SERT in bowel associated with inflammatory bowel disease, inflammation, spastic colon and serotonin
13) Confidence 0.68 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16700726 Disease Relevance 0.39 Pain Relevance 0.42
Consistent with expression of a functional SERT, specific uptake of (3)H-serotonin in macrophages was sodium dependent and inhibited by fluoxetine (IC(50) 6.9 nM) and desipramine (IC(50) 32 nM) but not by nisoxetine or reserpine.
Gene_expression (expression) of SERT in macrophages associated with desipramine, serotonin and fluoxetine
14) Confidence 0.68 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15652409 Disease Relevance 0 Pain Relevance 0.35
In previous work we showed that the serotonin transporter (5-HTT) is expressed in osteoclasts and that its activity is required by for osteoclast differentiation in vitro.
Gene_expression (expressed) of serotonin transporter in osteoclast associated with serotonin
15) Confidence 0.68 Published 2007 Journal J. Cell. Biochem. Section Abstract Doc Link 17041947 Disease Relevance 0 Pain Relevance 0.43
Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown.
Gene_expression (expression) of 5-HTT associated with anxiety disorder and serotonin
16) Confidence 0.68 Published 2004 Journal Science Section Abstract Doc Link 15514160 Disease Relevance 0.10 Pain Relevance 0.21
Taking advantage of our previous observation that ectopic expression of Zic2 in the central retina induces the expression of Sert (Figure 3B), we took a gain-of-function approach instead.
Gene_expression (expression) of Sert in retina
17) Confidence 0.66 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.05 Pain Relevance 0.03
The transcriptional mechanisms controlling serotonin signalling in these neurons probably differ from those uncovered in the raphe nuclei, as none of the genes that regulate the serotonin phenotype in the raphe have been found in areas that transiently express Sert.
Gene_expression (express) of Sert in neurons associated with raphe and serotonin
18) Confidence 0.66 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.64
These results demonstrate that Zic2 is able to regulate the expression of Sert in iRGCs in vivo by direct binding to its promoter region.


Gene_expression (expression) of Sert
19) Confidence 0.66 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.04
To investigate whether Sert, like Zic2, is expressed in iRGCs and not in cRGCs, we performed immunostaining for Sert in semi-intact whole-mount preparations of the ventral diencephalon containing the entire optic chiasm region.
Gene_expression (expressed) of Sert in ventral
20) Confidence 0.66 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.07

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