INT91776

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.26
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr3c1) nucleus (Nr3c1) intracellular (Nr3c1)
DNA binding (Nr3c1) protein complex (Nr3c1) transcription factor binding (Nr3c1)
Anatomy Link Frequency
brain 4
hypothalamus 2
Nr3c1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 9 99.68 Very High Very High Very High
Dopamine 5 95.68 Very High Very High Very High
Eae 2 87.48 High High
antidepressant 7 86.56 High High
fluoxetine 9 85.12 High High
dopamine receptor 1 65.84 Quite High
spastic colon 1 63.00 Quite High
Substantia nigra 2 45.04 Quite Low
Endep 4 38.40 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 99.78 Very High Very High Very High
Depression 9 99.68 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 88.76 High High
Stress 3 88.00 High High
Sleep Disorders 1 64.44 Quite High
Chronic Fatigue Syndrome 1 64.04 Quite High
Functional Bowel Disorder 1 63.00 Quite High
Urticaria 1 61.08 Quite High
Hypersensitivity 1 60.68 Quite High
Common Cold 1 60.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice bearing a transgene coding for a glucocorticoid receptor antisense mRNA that partially blocks glucocorticoid receptor expression were used to investigate the long-term effect of hypothalamic-pituitary-adrenal dysfunction on brain 5-hydroxytryptamine-2A (5-HT2A) receptor expression.
Negative_regulation (blocks) of Gene_expression (expression) of glucocorticoid receptor in brain associated with targeted disruption
1) Confidence 0.42 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11174015 Disease Relevance 0.39 Pain Relevance 0.13
They consisted of knock-out mice lacking the 5-HT transporter (5-HTT-/-) and of transgenic mice with impaired glucocorticoid receptor (GR-i) expression.
Negative_regulation (impaired) of Gene_expression (expression) of glucocorticoid receptor associated with targeted disruption
2) Confidence 0.39 Published 2000 Journal Neurochem. Res. Section Abstract Doc Link 11059794 Disease Relevance 0.53 Pain Relevance 0.17
Transgenic mice bearing a transgene coding for a glucocorticoid receptor antisense mRNA, which partially blocks glucocorticoid receptor expression, were used to investigate the long-term effect of hypothalamic-pituitary-adrenal axis dysfunction on brain dopamine transmission.
Negative_regulation (blocks) of Gene_expression (expression) of glucocorticoid receptor in brain associated with targeted disruption and dopamine
3) Confidence 0.38 Published 2001 Journal Neuroscience Section Abstract Doc Link 11226678 Disease Relevance 0.32 Pain Relevance 0.23
Levels of corticotropin-releasing hormone mRNA expression in the hypothalamus and proopiomelanocortin mRNA expression in the pituitary were significantly increased, and glucocorticoid receptor protein expression in the hypothalamus paraventricular nucleus was downregulated in the depression-like model mice.
Negative_regulation (downregulated) of Gene_expression (expression) of glucocorticoid receptor protein in hypothalamus associated with depression
4) Confidence 0.25 Published 2006 Journal Phytomedicine Section Abstract Doc Link 16516452 Disease Relevance 1.02 Pain Relevance 0.50

General Comments

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