INT9178

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Context Info
Confidence 0.45
First Reported 1981
Last Reported 2009
Negated 3
Speculated 2
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 2.28
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
pituitary 6
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 31 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
narcan 11 100.00 Very High Very High Very High
Neurotransmitter 4 100.00 Very High Very High Very High
Neuropeptide 3 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 99.88 Very High Very High Very High
Somatostatin 25 99.54 Very High Very High Very High
Serotonin 7 99.12 Very High Very High Very High
anesthesia 2 98.84 Very High Very High Very High
opiate 8 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 13 99.84 Very High Very High Very High
Hypoglycemia 1 97.32 Very High Very High Very High
Hyperglycemia 2 96.72 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

5 94.64 High High
Endocrine Disease 1 92.24 High High
Overdose 1 90.72 High High
Panic Disorder 4 90.64 High High
Body Weight 2 88.56 High High
Aging 33 82.60 Quite High
Hypopituitarism 2 75.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed that (a) pituitary responsiveness to GHRH changes throughout the estrous cycle is maximal in diestrus and minimal in proestrus; (b) GHRH stimulated GH secretion in intact and ovariectomized females on days 45, 60 and 90, but not on day 30; (c) the age increase of GH responsiveness to GHRH administration was slightly reduced in animals ovariectomized on day 23; (e) the age increase of pituitary GH content was similar in control and ovariectomized females; and (d) ovariectomy on day 83 reduced pituitary responsiveness to GHRH more effectively than ovariectomy on day 23.
Regulation (responsiveness) of Localization (administration) of GHRH in pituitary
1) Confidence 0.45 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1834957 Disease Relevance 0 Pain Relevance 0.07
We have examined the effect of glucose and FFA on GH-releasing factor (GHRF)-mediated GH secretion in rats under pentobarbital anesthesia.
Spec (examined) Regulation (effect) of Localization (secretion) of GHRF associated with anesthesia
2) Confidence 0.45 Published 1986 Journal Endocrinology Section Abstract Doc Link 2870916 Disease Relevance 0.27 Pain Relevance 0.10
The inhibitory effects of growth hormone-releasing hormone (GHRH)-antagonist on GHRH, L-dopa, and clonidine-induced GH secretion in normal subjects.
Regulation (effects) of Localization (secretion) of GHRH associated with antagonist and clonidine
3) Confidence 0.34 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 8626863 Disease Relevance 0 Pain Relevance 0.50
In the presence of propranolol (10(-5) M), a beta-adrenergic blocking agent, clonidine (10(-5) and 10(-4) M) stimulated GRF release more prominently in a dose-related manner, whereas propranolol (10(-5) and 10(-4) M) by itself did not affect the spontaneous GRF release.
Neg (not) Regulation (affect) of Localization (release) of GRF associated with clonidine
4) Confidence 0.27 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.28
For example, the arcuate nucleus neurones controlling the secretion of GHRH, which increases GH release from the pituitary [249], are modulated by ?
Regulation (controlling) of Localization (secretion) of GHRH in pituitary
5) Confidence 0.24 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687936 Disease Relevance 0 Pain Relevance 0.24
To investigate the possible involvement of somatostatin (SRIF) in the inhibition of GH secretion by CGRP, the effect of the peptide on GHRH-induced GH release was also examined in rats with hypothalamic SRIF depletion obtained by pretreatment (4 h before) with cysteamine (300 mg/kg subcutaneously).
Regulation (effect) of Localization (release) of GHRH associated with somatostatin and calcitonin gene-related peptide
6) Confidence 0.24 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2785661 Disease Relevance 0 Pain Relevance 0.93
Sex-related naloxone influence on growth hormone-releasing hormone-induced growth hormone secretion in normal subjects.
Regulation (influence) of Localization (secretion) of growth hormone-releasing hormone associated with narcan
7) Confidence 0.22 Published 1987 Journal Metab. Clin. Exp. Section Title Doc Link 3100909 Disease Relevance 0 Pain Relevance 0.68
We investigated the effects of 14 chemicals, including neuropeptides, pineal hormones, neurotransmitters, and neuromodulators (growth hormone-releasing hormone: GHRH, thyrotropin-releasing hormone, corticotropin-releasing hormone: CRH, gonadotropin-releasing hormone, melatonin, N-acetyl serotonin, serotonin, beta-endorphin, enkephalin, dopamine, norepinephrine, epinephrine, acetylcholine, and histamine) on the onset of downstream migration in chum salmon (Oncorhynchus keta) fry.
Spec (investigated) Regulation (effects) of Localization (gonadotropin-releasing hormone) of GHRH associated with dopamine, neurotransmitter, neuropeptide, enkephalin and serotonin
8) Confidence 0.20 Published 2009 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Abstract Doc Link 19068234 Disease Relevance 0 Pain Relevance 0.44
The results indicate that the alpha-adrenergic influence on the secretion of GH is mediated not by inhibition of somatostatin release but rather by effects on the release of a GHRF.
Neg (not) Regulation (effects) of Localization (release) of GHRF associated with somatostatin
9) Confidence 0.18 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6114446 Disease Relevance 0 Pain Relevance 0.25
In addition they suggest that impairment of GH secretion in thyroidectomized rats does not depend upon changes in the hypothalamic SRIF regulation of the hormone but could be dependent on a defect in GRF release and/or, most probably, GH synthesis directly at the pituitary level.
Regulation (dependent) of Localization (release) of GRF in pituitary associated with somatostatin
10) Confidence 0.15 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2867482 Disease Relevance 0 Pain Relevance 0.28
The aim of our study was to evaluate the effects of GH-releasing hormone (GHRH) and clonidine, an alpha-2-adrenergic agonist which increases GH secretion acting at the hypothalamic level with an unknown mechanism, on GH secretion in seven adult patients (3M, 4F) with non endocrine diseases and on daily immunosuppressive glucocorticoid therapy.
Regulation (effects) of Localization (releasing) of GHRH associated with endocrine disease, agonist and clonidine
11) Confidence 0.14 Published 1992 Journal Horm. Metab. Res. Section Abstract Doc Link 1398465 Disease Relevance 0.09 Pain Relevance 0.33
Basal GH responses to GHRH stimulation were normal and did not change change after alprazolam treatment.
Neg (not) Regulation (change) of Localization (responses) of GHRH
12) Confidence 0.12 Published 1995 Journal Psychoneuroendocrinology Section Abstract Doc Link 7838898 Disease Relevance 0.24 Pain Relevance 0.34
Similarly growth hormone secretion in response to growth hormone releasing hormone ( GHRH ), clonidine, naloxone and arginine is also altered in obesity.
Regulation (altered) of Localization (secretion) of growth hormone releasing hormone associated with obesity, narcan and clonidine
13) Confidence 0.10 Published 1993 Journal Prog Food Nutr Sci Section Abstract Doc Link 8372228 Disease Relevance 1.03 Pain Relevance 0.28
However, the potentiating effect of these drugs on the GHRH-induced GH secretion was only observed for PRO.
Regulation (effect) of Localization (secretion) of GHRH
14) Confidence 0.08 Published 1995 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 7626468 Disease Relevance 0 Pain Relevance 0.31
GHS effects are influenced by the same factors which modulate endogenous GHRH secretion, such as negative feedback by somatostatin.
Regulation (modulate) of Localization (secretion) of GHRH associated with somatostatin
15) Confidence 0.06 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.25 Pain Relevance 0.05

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