INT9179

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2008
Negated 2
Speculated 1
Reported most in Abstract
Documents 42
Total Number 45
Disease Relevance 7.05
Pain Relevance 18.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh) extracellular region (Ghrh)
Anatomy Link Frequency
hypothalamus 18
pituitary 12
plasma 6
somatotrophs 4
molar 2
Ghrh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 227 100.00 Very High Very High Very High
Clonidine 181 100.00 Very High Very High Very High
adenocard 7 100.00 Very High Very High Very High
antagonist 89 99.92 Very High Very High Very High
Inflammation 58 99.92 Very High Very High Very High
Neurotransmitter 22 99.80 Very High Very High Very High
agonist 55 99.56 Very High Very High Very High
qutenza 4 99.30 Very High Very High Very High
Potency 8 98.20 Very High Very High Very High
electroacupuncture 4 97.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 10 98.92 Very High Very High Very High
Hyperglycemia 2 98.30 Very High Very High Very High
Fibromyalgia 16 97.00 Very High Very High Very High
Syndrome 20 96.40 Very High Very High Very High
INFLAMMATION 59 96.20 Very High Very High Very High
Frailty 27 96.08 Very High Very High Very High
Depression 9 95.56 Very High Very High Very High
Aids-related Complex 8 94.28 High High
Stress 105 93.12 High High
Hypopituitarism 8 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that alpha 2-adrenergic mechanisms play a role in stimulating GRF release from the hypothalamus in rats.
Positive_regulation (stimulating) of Localization (release) of GRF in hypothalamus
1) Confidence 0.70 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.25
A high potassium concentration (56 mM) stimulated GRF release from the hypothalamus.
Positive_regulation (stimulated) of Localization (release) of GRF in hypothalamus
2) Confidence 0.70 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.24
CLO reportedly stimulates GH release via increased release of GH-releasing hormone (GHRH) from the hypothalamus.
Positive_regulation (increased) of Localization (release) of GH-releasing hormone in hypothalamus associated with clonidine
3) Confidence 0.67 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2162745 Disease Relevance 0.06 Pain Relevance 0.78
The infusion of clonidine (10(-4) M), an alpha 2-adrenergic stimulant, resulted in an increase in the spontaneous release of GRF.
Positive_regulation (increase) of Localization (release) of GRF associated with clonidine
4) Confidence 0.61 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.27
The increase in growth hormone secretion in experimentally induced arthritic rats is an adaptive process involved in the regulation of inflammation.
Positive_regulation (increase) of Localization (secretion) of hormone associated with inflammation and arthritis
5) Confidence 0.57 Published 1996 Journal Neuroendocrinology Section Title Doc Link 8839359 Disease Relevance 0.82 Pain Relevance 0.60
These results indicate that 1) functional activation of alpha-2 adrenergic receptors by CLO increases GHRH release from the hypothalamus, 2) CLO, via GHRH, increases GH secretion and biosynthesis, which in turn feeds back in the hypothalamus to reduce GHRH biosynthesis, and 3) reduction of hypothalamic GH-stimulatory activity tones down the initial pituitary somatotropic hyperfunction.
Positive_regulation (increases) of Localization (release) of GHRH in hypothalamus associated with clonidine
6) Confidence 0.50 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632352 Disease Relevance 0 Pain Relevance 1.00
In 10-day-old rats made hypothyroid by giving dams propylthiouracil (PTU) in the drinking water since the day of parturition, simultaneous radioimmunoassay (RIA) determinations of basal and stimulated growth hormone (GH) secretion, hypothalamic GH-releasing hormone (GHRH)-like immunoreactivity (LI) content, immunocytochemical localization of somatotrophs, and hypothalamic GHRH-LI-positive structures were performed.
Positive_regulation (stimulated) of Localization (localization) of GHRH in somatotrophs
7) Confidence 0.48 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3124121 Disease Relevance 0 Pain Relevance 0
CLO reportedly stimulates GH release via increased release of GH-releasing hormone (GHRH) from the hypothalamus.
Positive_regulation (stimulates) of Localization (release) of GHRH in hypothalamus associated with clonidine
8) Confidence 0.48 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2162745 Disease Relevance 0.06 Pain Relevance 0.79
CLO reportedly stimulates GH release via increased release of GH-releasing hormone (GHRH) from the hypothalamus.
Positive_regulation (increased) of Localization (release) of GHRH in hypothalamus associated with clonidine
9) Confidence 0.48 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2162745 Disease Relevance 0.06 Pain Relevance 0.79
In 10-day-old rats made hypothyroid by giving dams propylthiouracil (PTU) in the drinking water since the day of parturition, simultaneous radioimmunoassay (RIA) determinations of basal and stimulated growth hormone (GH) secretion, hypothalamic GH-releasing hormone (GHRH)-like immunoreactivity (LI) content, immunocytochemical localization of somatotrophs, and hypothalamic GHRH-LI-positive structures were performed.
Positive_regulation (stimulated) of Localization (secretion) of GH-releasing hormone in somatotrophs
10) Confidence 0.48 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3124121 Disease Relevance 0 Pain Relevance 0
CLO reportedly stimulates GH release via increased release of GH-releasing hormone (GHRH) from the hypothalamus.
Positive_regulation (increased) of Localization (release) of GH-releasing hormone in hypothalamus associated with clonidine
11) Confidence 0.48 Published 1990 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2162745 Disease Relevance 0.06 Pain Relevance 0.78
Replacing extracellular Na+ with mannitol or tris(hydroxymethyl)aminomethane (Tris+) suppressed hGRF- and dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP)-induced GH secretion.
Positive_regulation (induced) of Localization (secretion) of hGRF associated with adenocard
12) Confidence 0.47 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2833113 Disease Relevance 0 Pain Relevance 0.11
These findings suggest that KP-102 potently stimulates the GH release by a direct or indirect antagonism of somatostatin (SRIF) and growth hormone releasing hormone (GHRH) release in the hypothalamus and by a direct action on the pituitary.
Positive_regulation (antagonism) of Localization (release) of GHRH in hypothalamus associated with somatostatin
13) Confidence 0.47 Published 1996 Journal Life Sci. Section Abstract Doc Link 8761023 Disease Relevance 0.25 Pain Relevance 0.39
In the presence of propranolol (10(-5) M), a beta-adrenergic blocking agent, clonidine (10(-5) and 10(-4) M) stimulated GRF release more prominently in a dose-related manner, whereas propranolol (10(-5) and 10(-4) M) by itself did not affect the spontaneous GRF release.
Positive_regulation (stimulated) of Localization (release) of GRF associated with clonidine
14) Confidence 0.47 Published 1986 Journal Endocrinology Section Abstract Doc Link 2873027 Disease Relevance 0 Pain Relevance 0.28
It is suggested that the clonidine-induced GH secretion is modulated by a chain of events which involves primary stimulation of GHRH release resulting in increased GH secretion which, via a negative-feedback mechanism, triggers an enhancement of somatostatin release which ultimately normalizes the system.
Positive_regulation (stimulation) of Localization (release) of GHRH associated with somatostatin and clonidine
15) Confidence 0.46 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 1686052 Disease Relevance 0 Pain Relevance 0.57
It is suggested that the clonidine-induced GH secretion is modulated by a chain of events which involves primary stimulation of GHRH release resulting in increased GH secretion which, via a negative-feedback mechanism, triggers an enhancement of somatostatin release which ultimately normalizes the system.
Positive_regulation (resulting) of Localization (release) of GHRH associated with somatostatin and clonidine
16) Confidence 0.46 Published 1991 Journal J. Endocrinol. Section Abstract Doc Link 1686052 Disease Relevance 0 Pain Relevance 0.57
These results suggest that hyperglycemia does not change the GH response to GHRF and that elevation of plasma FFA suppresses GHRF-induced GH secretion by the stimulation of somatostatin secretion in rats.
Positive_regulation (induced) of Localization (secretion) of GHRF-induced in plasma associated with hyperglycemia and somatostatin
17) Confidence 0.46 Published 1986 Journal Endocrinology Section Abstract Doc Link 2870916 Disease Relevance 0.31 Pain Relevance 0.12
These results suggest that GH autofeedback is mediated by reduced GRF secretion, rather than enhanced SRIF release.
Positive_regulation (mediated) of Localization (secretion) of GRF associated with somatostatin
18) Confidence 0.46 Published 1985 Journal Endocrinology Section Abstract Doc Link 2866085 Disease Relevance 0.08 Pain Relevance 0.61
These results indicate that levodopa and clonidine (drugs stimulating hypothalamic GHRH release and secondary pituitary GH release in normal individuals) do not stimulate GH release in DS.
Positive_regulation (stimulating) of Localization (release) of GHRH in pituitary associated with syndrome and clonidine
19) Confidence 0.46 Published 1996 Journal J Intellect Disabil Res Section Abstract Doc Link 9004111 Disease Relevance 0.72 Pain Relevance 0.43
It is concluded that the inhibitory potency of GHRH-Ant on GHRH(1-44)NH2 is relatively weak (about 1/60 in molar base), and that L-dopa- or clonidine-induced GH release seems to be mediated by the release of hypothalamic GHRH.
Positive_regulation (mediated) of Localization (release) of GHRH in molar associated with clonidine and potency
20) Confidence 0.44 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8626863 Disease Relevance 0 Pain Relevance 0.48

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