INT918
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In order to ascertain whether there is a relation between opioids and the serotoninergic system in prolactin (PRL) secretion increase, we investigated in seven healthy men (21 to 26 years of age) the effect of naloxone, a specific opioid antagonist, on PRL secretion induced by fenfluramine, a drug that stimulates serotonin release and inhibits its re-uptake. | |||||||||||||||
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Naloxone reduces the fenfluramine-induced prolactin release in man. | |||||||||||||||
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Higher doses of naloxone (30 mg) do not further inhibit the PRL secretion induced by fenfluramine. | |||||||||||||||
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They observed that naloxone is not able to reduce either basal PRL secretion in menopausal women, or puerperal hyperprolactinemia, or PRL release induced by mechanical breast stimulation. | |||||||||||||||
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In normal humans, ingestion of protein stimulates PRL secretion. | |||||||||||||||
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Administration of naloxone, phentolamine, or propranolol did not alter the PRL response to the various test meals, indicating that neither opioid, alpha-adrenergic, nor beta-adrenergic stimulation is involved in meal-induced PRL secretion. | |||||||||||||||
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Enhancement of insulin-induced prolactin secretion by fluoxetine in man. | |||||||||||||||
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Fluoxetine significantly enhanced insulin-induced PRL release. | |||||||||||||||
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Morphine inhibits cortisol and stimulates prolactin secretion in man. | |||||||||||||||
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Morphine stimulated prolactin release. | |||||||||||||||
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Monotherapy-treated patients rarely reported symptoms due to increased prolactin secretion, while in patients on antipsychotic drugs that stimulate prolactin secretion, serotoninergic antidepressants may elevate prolactin levels above symptomatic levels or worsen pre-existing symptoms (Haddad and Wieck 2000). | |||||||||||||||
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Monotherapy-treated patients rarely reported symptoms due to increased prolactin secretion, while in patients on antipsychotic drugs that stimulate prolactin secretion, serotoninergic antidepressants may elevate prolactin levels above symptomatic levels or worsen pre-existing symptoms (Haddad and Wieck 2000). | |||||||||||||||
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Fluoxetine induces a 5HT receptor–mediated stimulation of prolactin secretion and is reported to increase prolactin levels more than tricyclics (Meltzer et al 1997). | |||||||||||||||
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SSRI actually cause little, if any, increase in prolactin secretion. | |||||||||||||||
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Since it is prevented by a previous injection of the specific opiate antagonist naloxone, morphine- and methadone-induced prolactin secretion seems to be primarily mediated by ? | |||||||||||||||
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Opioids may indirectly stimulate prolactin release by inhibiting PIFs (ie, dopamine) release and/or by stimulating PRFs production (Shin et al 1988) (Figure 2). | |||||||||||||||
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Since it is prevented by a previous injection of the specific opiate antagonist naloxone, morphine- and methadone-induced prolactin secretion seems to be primarily mediated by ? | |||||||||||||||
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L-sulpiride is an antagonist of dopamine on D2 receptors therefore inhibits the action of dopamine increasing the secretion of prolactin. | |||||||||||||||
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Droperidol-induced increase in prolactin secretion was significant already at ten minutes after the administration reaching the peak after 20 minutes. | |||||||||||||||
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L-sulpiride increased prolactin secretion reaching the maximum increase 20 minutes after the administration of 50 mg of the drug, and 30 minutes after the administration of 100 mg doses. | |||||||||||||||
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General Comments
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