INT91811

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Context Info
Confidence 0.21
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FAS, TP53) protein complex assembly (FAS, TP53) cytoplasm (FAS, TP53)
cytosol (FAS, TP53) cell differentiation (TP53) nucleoplasm (TP53)
Anatomy Link Frequency
pore 1
FAS (Homo sapiens)
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 1 95.92 Very High Very High Very High
Inflammation 1 92.24 High High
Dopamine 1 66.24 Quite High
agonist 1 65.52 Quite High
cINOD 2 48.56 Quite Low
cytokine 2 35.52 Quite Low
Nerve growth factor 3 30.64 Quite Low
Disease Link Frequency Relevance Heat
Disease 1 98.52 Very High Very High Very High
Death 3 97.88 Very High Very High Very High
Demyelinating Disease 1 95.92 Very High Very High Very High
Neurodegenerative Disease 4 94.32 High High
Stress 1 92.88 High High
INFLAMMATION 2 92.24 High High
Toxicity 1 89.68 High High
Apoptosis 5 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell surface receptors (e.g., CD95/APO-1/Fas; TNF receptor) and their ligands (CD95-L; TNF) as well as evolutionarily conserved mechanisms involving proteases, mitochondrial factors (e.g. , Bcl-2-related proteins, reactive oxygen species, mitochondrial membrane potential, opening of the permeability transition pore) or p53 participate in the modulation and execution of cell death.
CD95 Binding (ligands) of p53 in pore associated with death
1) Confidence 0.21 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060707 Disease Relevance 1.10 Pain Relevance 0.16

General Comments

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