INT91813

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Context Info
Confidence 0.23
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 9.89
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FAS, FASLG) extracellular region (FAS, FASLG) plasma membrane (FAS, FASLG)
aging (FAS) protein complex assembly (FAS) cell-cell signaling (FASLG)
Anatomy Link Frequency
T lymphocyte 4
lymphocyte 2
pore 1
FAS (Homo sapiens)
FASLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 3 95.92 Very High Very High Very High
cytokine 132 93.44 High High
chemokine 60 88.08 High High
Inflammation 29 76.76 Quite High
Arthritis 110 55.00 Quite High
rheumatoid arthritis 20 54.84 Quite High
Dopamine 1 47.12 Quite Low
agonist 1 46.40 Quite Low
cINOD 12 29.44 Quite Low
Nerve growth factor 7 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 161 99.90 Very High Very High Very High
Death 59 99.50 Very High Very High Very High
Disease 75 98.52 Very High Very High Very High
Infection 102 96.52 Very High Very High Very High
Demyelinating Disease 3 95.92 Very High Very High Very High
Neurodegenerative Disease 18 94.32 High High
Lymphopenia 4 93.88 High High
Autoimmune Disease 44 92.84 High High
Autoimmune Lymphoproliferative Syndrome 4 92.40 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This lymphocyte apoptosis is likely to involve several pathways, but we show that apoptosis via Fas/FasL interaction is largely responsible for the massive lymphocyte death observed in human fatal ZEBOV infection.
Fas Binding (interaction) of FasL in lymphocyte associated with apoptosis, infection and death
1) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 1.67 Pain Relevance 0
, and profound immunosuppression resulting from massive peripheral T lymphocyte apoptosis mediated probably in great part by Fas/FasL interactions.
Fas Binding (interactions) of FasL in T lymphocyte associated with apoptosis
2) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.59 Pain Relevance 0.22
, and profound immunosuppression resulting from massive peripheral T lymphocyte apoptosis mediated probably in great part by Fas/FasL interactions.
Fas Binding (interactions) of FasL in T lymphocyte associated with apoptosis
3) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.59 Pain Relevance 0.22
This lymphocyte apoptosis is likely to involve several pathways, but we show that apoptosis via Fas/FasL interaction is largely responsible for the massive lymphocyte death observed in human fatal ZEBOV infection.
Fas Binding (interaction) of FasL in lymphocyte associated with apoptosis, infection and death
4) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 1.67 Pain Relevance 0
Clonally expanded T cells that have served their functional purpose are also cleared from the system through activation induced cell death (AICD) involving cell surface FasL/Fas receptor interaction [13].
Fas Spec (cleared) Binding (interaction) of FasL in T cells associated with death
5) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.47 Pain Relevance 0.19
Clonally expanded T cells that have served their functional purpose are also cleared from the system through activation induced cell death (AICD) involving cell surface FasL/Fas receptor interaction [13].
Fas Spec (cleared) Binding (interaction) of FasL in T cells associated with death
6) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.47 Pain Relevance 0.19
Cell surface receptors (e.g., CD95/APO-1/Fas; TNF receptor) and their ligands (CD95-L; TNF) as well as evolutionarily conserved mechanisms involving proteases, mitochondrial factors (e.g. , Bcl-2-related proteins, reactive oxygen species, mitochondrial membrane potential, opening of the permeability transition pore) or p53 participate in the modulation and execution of cell death.
CD95 Binding (ligands) of CD95-L in pore associated with death
7) Confidence 0.07 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060707 Disease Relevance 0.92 Pain Relevance 0.08
Moreover, the proapoptotic molecules Fas and Fas ligand (FasL) undergo positive transcriptional regulation after exposure to oxidants [27].
Fas Binding (ligand) of FasL
8) Confidence 0.06 Published 2008 Journal Nutr J Section Body Doc Link PMC2572622 Disease Relevance 0.75 Pain Relevance 0.04
Moreover, the proapoptotic molecules Fas and Fas ligand (FasL) undergo positive transcriptional regulation after exposure to oxidants [27].
Fas Binding (ligand) of FasL
9) Confidence 0.06 Published 2008 Journal Nutr J Section Body Doc Link PMC2572622 Disease Relevance 0.75 Pain Relevance 0.04

General Comments

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