INT91817

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Context Info
Confidence 0.34
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 21.40
Pain Relevance 13.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (RETNLB) extracellular region (RETNLB) molecular_function (RETNLB)
cellular_component (RETNLB)
Anatomy Link Frequency
spinal cord 2
leukocyte 1
brain 1
uterine 1
bowel 1
RETNLB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 188 100.00 Very High Very High Very High
cytokine 139 100.00 Very High Very High Very High
Inflammatory mediators 10 100.00 Very High Very High Very High
chemokine 10 100.00 Very High Very High Very High
Inflammatory response 24 99.88 Very High Very High Very High
qutenza 9 99.40 Very High Very High Very High
spastic colon 4 99.28 Very High Very High Very High
Central nervous system 11 98.96 Very High Very High Very High
psoriasis 1 98.92 Very High Very High Very High
Spinal cord 8 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 224 100.00 Very High Very High Very High
Stress 16 100.00 Very High Very High Very High
Adhesions 8 100.00 Very High Very High Very High
Chorioamnionitis 2 99.68 Very High Very High Very High
Pancreatic Cancer 81 99.52 Very High Very High Very High
Erythema 6 99.44 Very High Very High Very High
Dengue Hemorrhagic Fever 205 99.28 Very High Very High Very High
Functional Bowel Disorder 2 99.28 Very High Very High Very High
Syndrome 18 99.10 Very High Very High Very High
Psoriasis 1 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, compelling evidence has evolved that the up-regulation of pro-inflammatory cytokines plays an important role in induction of the late phase of ischemic preconditioning in rodent models.
Positive_regulation (up-regulation) of pro-inflammatory associated with inflammation and cytokine
1) Confidence 0.34 Published 2006 Journal Med. Hypotheses Section Abstract Doc Link 16806727 Disease Relevance 0.74 Pain Relevance 0.47
Patients with unstable coronary syndromes have a systemic inflammatory responses with increase of the pro-inflammatory cytokines, such as TNFalpha, IL-6.
Positive_regulation (increase) of pro-inflammatory associated with inflammatory response, inflammation, syndrome and cytokine
2) Confidence 0.34 Published 2006 Journal Med. Hypotheses Section Abstract Doc Link 16806727 Disease Relevance 0.94 Pain Relevance 0.67
It is well established that chemotherapy causes prominent small intestinal and colonic damage as a result of up-regulation of stress response genes and pro-inflammatory cytokines.
Positive_regulation (up-regulation) of pro-inflammatory associated with stress, inflammation and cytokine
3) Confidence 0.23 Published 2009 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 19305997 Disease Relevance 1.32 Pain Relevance 0.53
The cascade of altered neural activity includes the induction of pro-inflammatory cytokines within the brain and spinal cord.
Positive_regulation (induction) of pro-inflammatory in spinal cord associated with inflammation, spinal cord and cytokine
4) Confidence 0.22 Published 2003 Journal Brain Behav. Immun. Section Abstract Doc Link 12615198 Disease Relevance 0.58 Pain Relevance 0.73
The arrival of these signals in the central nervous system induces a neural cascade that includes the de novo induction of pro-inflammatory cytokines.
Positive_regulation (induction) of pro-inflammatory in central nervous system associated with inflammation, central nervous system and cytokine
5) Confidence 0.22 Published 2003 Journal Brain Behav. Immun. Section Abstract Doc Link 12676570 Disease Relevance 0.61 Pain Relevance 0.55
Furthermore, gene technological analyses of biopsies showed no upregulation of pro-inflammatory cytokines.
Neg (no) Positive_regulation (upregulation) of pro-inflammatory associated with inflammation and cytokine
6) Confidence 0.08 Published 2005 Journal Scand J Med Sci Sports Section Abstract Doc Link 15998342 Disease Relevance 0.85 Pain Relevance 0.96
The cascade of altered neural activity includes the induction of pro-inflammatory cytokines within the brain and spinal cord.
Positive_regulation (induction) of pro-inflammatory in brain associated with inflammation, spinal cord and cytokine
7) Confidence 0.08 Published 2003 Journal Brain Behav. Immun. Section Abstract Doc Link 12615198 Disease Relevance 0.58 Pain Relevance 0.73
We also observed that various pro-inflammatory mediators, including cytokines, chemokines, adhesion molecules, prostaglandin E(2) and its key enzyme COX-2, not iNOS or caspase-1, were markedly up-regulated by stimulation with these TLR and NOD agonists.
Positive_regulation (up-regulated) of pro-inflammatory associated with chemokine, inflammatory mediators, agonist, adhesions and cytokine
8) Confidence 0.01 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19734466 Disease Relevance 0.54 Pain Relevance 0.57
It is also well known that in patients with chorioamnionitis, the levels of pro-inflammatory cytokines are elevated in amniotic fluid, maternal serum, cervical secretion, placenta, and other compartments of the placento-maternal unit, and are associated with preterm uterine contractions.
Positive_regulation (elevated) of pro-inflammatory in uterine associated with reprotox - general 2, inflammation, chorioamnionitis, dismenorea and cytokine
9) Confidence 0.01 Published 2003 Journal BJOG Section Abstract Doc Link 12763128 Disease Relevance 1.08 Pain Relevance 0.62
Upregulation of these pro-inflammatory genes during the active phase of CH has not formerly been reported.
Positive_regulation (Upregulation) of pro-inflammatory
10) Confidence 0.01 Published 2006 Journal Headache Section Body Doc Link 17115985 Disease Relevance 0 Pain Relevance 0
Activation of a pro-inflammatory defence gene pattern in DSS patients' blood cells (Table 4) has relevance to the pathophysiology of systemic vascular dysfunction, since most microbicidal peptides and enzymes have recognized pro-inflammatory and pathogenic effects towards vascular endothelial tissues [50].
Positive_regulation (Activation) of pro-inflammatory in blood cells associated with inflammation and dengue hemorrhagic fever
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.61 Pain Relevance 0.40
PAMPS and DAMPS have been shown to activate the inflammasome ultimately leading to activation of the pro-inflammatory cytokine IL-1?.
Positive_regulation (activation) of pro-inflammatory associated with inflammation and cytokine
12) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727897 Disease Relevance 1.45 Pain Relevance 0.68
Inflammation plays an important role in the postoperative morbidity of organs, which is related to the activation of pro-inflammatory and anti-inflammatory cytokines.
Positive_regulation (activation) of pro-inflammatory associated with inflammation and cytokine
13) Confidence 0.01 Published 2010 Journal Korean Journal of Anesthesiology Section Abstract Doc Link PMC2876852 Disease Relevance 0.68 Pain Relevance 0.28
In addition, while elevated pro-inflammatory cytokines such as IL-1, IL-6 and TNF-?
Positive_regulation (elevated) of pro-inflammatory associated with inflammation and cytokine
14) Confidence 0.01 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 1.57 Pain Relevance 0.68
Recent evidence indicates that the hypoxic adaptive response in pancreatic cancer cells may also involve upregulation of pro-inflammatory cytokines.
Positive_regulation (upregulation) of pro-inflammatory associated with inflammation, hypoxia, pancreatic cancer and cytokine
15) Confidence 0.00 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.69 Pain Relevance 0.14
Several in vivo studies have demonstrated an acute-phase reaction after the first administration of aminobisphosphonates, with a significant increase in the main pro-inflammatory cytokines.
Positive_regulation (increase) of pro-inflammatory associated with inflammation and cytokine
16) Confidence 0.00 Published 2004 Journal BioDrugs Section Abstract Doc Link 15244502 Disease Relevance 1.58 Pain Relevance 0.57
Pro-inflammatory cytokine mRNA was significantly increased in the antral mucosa of all infected gerbils.
Positive_regulation (increased) of Pro-inflammatory
17) Confidence 0.00 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17663507 Disease Relevance 0 Pain Relevance 0
In contrast, pro-inflammatory cytokines, the Th2 cell cytokine IL-4, and the CC-chemokine MCP-1 were significantly increased in BAL-cells of capsaicin pretreated and MDI-sensitized rats, whilst in the normal MDI-sensitized rats markedly less pronounced changes (if any) occurred.
Positive_regulation (creased i) of pro-inflammatory in Th2 cell associated with chemokine, qutenza, inflammation and cytokine
18) Confidence 0.00 Published 2006 Journal Toxicology Section Abstract Doc Link 17011108 Disease Relevance 0.38 Pain Relevance 0.95
De novo upregulation of pro-inflammatory cytokines, chemokines and endothelial-leukocyte adhesion molecules occurs soon after focal ischaemia and trauma, as well as at the time when the tissue injury is evolving.
Positive_regulation (upregulation) of pro-inflammatory in leukocyte associated with chemokine, inflammation, injury, cv unclassified under development, adhesions and cytokine
19) Confidence 0.00 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060807 Disease Relevance 1.83 Pain Relevance 0.66
Thus, the activation of pro-inflammatory cytokines in erythema migrans lesions, particularly interferon-gamma, seems to be important in the control of the spirochetal infection.
Positive_regulation (activation) of pro-inflammatory associated with erythema, inflammation, infection and cytokine
20) Confidence 0.00 Published 2000 Journal J. Invest. Dermatol. Section Abstract Doc Link 11121150 Disease Relevance 1.99 Pain Relevance 0.85

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