INT91825

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Context Info
Confidence 0.31
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 2.39
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (HBEGF) extracellular space (HBEGF) extracellular region (HBEGF)
plasma membrane (HBEGF)
Anatomy Link Frequency
BUC 1
epithelial cells 1
urine 1
HBEGF (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 26 99.80 Very High Very High Very High
pain pelvic 2 96.84 Very High Very High Very High
Prostatitis 1 94.44 High High
cytokine 1 67.52 Quite High
Hyperalgesia 1 66.36 Quite High
Disease Link Frequency Relevance Heat
Interstitial Cystitis 26 99.80 Very High Very High Very High
Chronic Pelvic Pain Syndrome 2 97.16 Very High Very High Very High
Reprotox - General 1 1 94.44 High High
Congenital Anomalies 1 69.08 Quite High
Hyperalgesia 1 66.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of IC BUC with heparin-binding epidermal growth factor-like growth factor (HB-EGF), previously shown to be secreted in lower amounts by IC BUC, significantly increased inward potassium current.
heparin-binding epidermal growth factor-like growth factor Binding (heparin-binding) of in BUC associated with interstitial cystitis
1) Confidence 0.31 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837648 Disease Relevance 1.03 Pain Relevance 1.07
We previously identified an interstitial cystitis urine factor, antiproliferative factor, that inhibits proliferation of bladder epithelial cells in vitro and complex changes in epithelial growth factor levels, including profound decreases in heparin-binding epidermal growth factor-like growth factor (HB-EGF).
heparin-binding epidermal growth factor-like growth factor Binding (heparin-binding) of in urine associated with interstitial cystitis
2) Confidence 0.30 Published 2000 Journal J. Urol. Section Abstract Doc Link 11061938 Disease Relevance 0.44 Pain Relevance 0.50
Bladder epithelial cells from patients with interstitial cystitis produce an inhibitor of heparin-binding epidermal growth factor-like growth factor production.
heparin-binding epidermal growth factor-like growth factor Binding (heparin-binding) of in epithelial cells associated with interstitial cystitis
3) Confidence 0.30 Published 2000 Journal J. Urol. Section Title Doc Link 11061938 Disease Relevance 0.45 Pain Relevance 0.52
Antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor in men with interstitial cystitis versus chronic pelvic pain syndrome.
heparin-binding epidermal growth factor-like growth factor Binding (heparin-binding) of associated with pain pelvic, interstitial cystitis and chronic pelvic pain syndrome
4) Confidence 0.30 Published 2004 Journal Urology Section Title Doc Link 14751340 Disease Relevance 0.47 Pain Relevance 0.43

General Comments

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