INT91830

Context Info Confidence 0.31 First Reported 2000 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 4 Total Number 5 Disease Relevance 2.24 Pain Relevance 1.03

cell proliferation (CD81) plasma membrane (CD81)

Anatomy Link Frequency epithelial cells 2 endothelial cells 1 ureter 1 brains 1 CD81 (Homo sapiens)

Pain Link Frequency Relevance Heat interstitial cystitis 18 99.68 cytokine 11 26.96 Osteoarthritis 8 5.00 Neurobehavioral 7 5.00 chemokine 7 5.00 Inflammation 4 5.00 Central nervous system 3 5.00 glial activation 2 5.00 Inflammatory response 2 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Interstitial Cystitis 18 99.68 Aging 3 99.20 Hepatitis C Virus Infection 189 98.72 Infection 34 77.28 Acquired Immune Deficiency Syndrome Or Hiv Infection 73 57.80 Osteoarthritis 15 55.96 Arrhythmias 2 Under Development 1 36.24 Drug Induced Neurotoxicity 12 34.00 Sprains And Strains 4 20.00 Targeted Disruption 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both microglia and astrocytes were previously identified as HCV-infected cells in autopsied brains [9], [18] and were shown to express SR-BI, CD81, claudin-1 and occludin [22], [23], [24], [25], [26].

Gene_expression (express) of CD81 in brains associated with hepatitis c virus infection

1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.06 Pain Relevance 0

These clones were negative for markers of hematopoetic stem cells (CD45) and endothelial cells (CD31) but positive (with variable expression) for MSC markers CD13, CD105, CD73, CD166, SSEA4, CD81, and CD90.

Neg (negative) Gene_expression (negative) of CD81 in endothelial cells

2) Confidence 0.14 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC3003945 Disease Relevance 0.16 Pain Relevance 0

Therefore, we determined whether bladder epithelial cells from interstitial cystitis cases produced the antiproliferative factor and whether purified antiproliferative factor could alter production of growth factors known to be abnormal in interstitial cystitis.

Spec (whether) Gene_expression (produced) of antiproliferative factor in epithelial cells associated with interstitial cystitis

3) Confidence 0.02 Published 2000 Journal J. Urol. Section Abstract Doc Link 11061938 Disease Relevance 0.52 Pain Relevance 0.52

RESULTS: Bladder epithelial cells from patients with interstitial cystitis produced a single antiproliferative factor with the same purification profile as that purified from interstitial cystitis urine.

Gene_expression (produced) of antiproliferative factor in epithelial cells

4) Confidence 0.02 Published 2000 Journal J. Urol. Section Body Doc Link 11061938 Disease Relevance 0.08 Pain Relevance 0

Bladder and renal pelvic catheterization of patients with interstitial cystitis indicated that the antiproliferative factor is made and/or activated in the distal ureter or bladder.

Gene_expression (made) of antiproliferative factor in ureter associated with interstitial cystitis

5) Confidence 0.02 Published 2000 Journal J. Urol. Section Abstract Doc Link 11061938 Disease Relevance 0.43 Pain Relevance 0.51

General Comments

This test has worked.