INT91830

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Context Info
Confidence 0.31
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.24
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD81) plasma membrane (CD81)
Anatomy Link Frequency
epithelial cells 2
endothelial cells 1
ureter 1
brains 1
CD81 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 18 99.68 Very High Very High Very High
cytokine 11 26.96 Quite Low
Osteoarthritis 8 5.00 Very Low Very Low Very Low
Neurobehavioral 7 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Interstitial Cystitis 18 99.68 Very High Very High Very High
Aging 3 99.20 Very High Very High Very High
Hepatitis C Virus Infection 189 98.72 Very High Very High Very High
Infection 34 77.28 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 73 57.80 Quite High
Osteoarthritis 15 55.96 Quite High
Arrhythmias 2 Under Development 1 36.24 Quite Low
Drug Induced Neurotoxicity 12 34.00 Quite Low
Sprains And Strains 4 20.00 Low Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both microglia and astrocytes were previously identified as HCV-infected cells in autopsied brains [9], [18] and were shown to express SR-BI, CD81, claudin-1 and occludin [22], [23], [24], [25], [26].
Gene_expression (express) of CD81 in brains associated with hepatitis c virus infection
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.06 Pain Relevance 0
These clones were negative for markers of hematopoetic stem cells (CD45) and endothelial cells (CD31) but positive (with variable expression) for MSC markers CD13, CD105, CD73, CD166, SSEA4, CD81, and CD90.
Neg (negative) Gene_expression (negative) of CD81 in endothelial cells
2) Confidence 0.14 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC3003945 Disease Relevance 0.16 Pain Relevance 0
Therefore, we determined whether bladder epithelial cells from interstitial cystitis cases produced the antiproliferative factor and whether purified antiproliferative factor could alter production of growth factors known to be abnormal in interstitial cystitis.
Spec (whether) Gene_expression (produced) of antiproliferative factor in epithelial cells associated with interstitial cystitis
3) Confidence 0.02 Published 2000 Journal J. Urol. Section Abstract Doc Link 11061938 Disease Relevance 0.52 Pain Relevance 0.52
RESULTS: Bladder epithelial cells from patients with interstitial cystitis produced a single antiproliferative factor with the same purification profile as that purified from interstitial cystitis urine.
Gene_expression (produced) of antiproliferative factor in epithelial cells
4) Confidence 0.02 Published 2000 Journal J. Urol. Section Body Doc Link 11061938 Disease Relevance 0.08 Pain Relevance 0
Bladder and renal pelvic catheterization of patients with interstitial cystitis indicated that the antiproliferative factor is made and/or activated in the distal ureter or bladder.
Gene_expression (made) of antiproliferative factor in ureter associated with interstitial cystitis
5) Confidence 0.02 Published 2000 Journal J. Urol. Section Abstract Doc Link 11061938 Disease Relevance 0.43 Pain Relevance 0.51

General Comments

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