INT91837

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 7
Disease Relevance 0.95
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2r1a) chromosome segregation (Ppp2r1a) chromosome (Ppp2r1a)
cytoplasm (Ppp2r1a)
Anatomy Link Frequency
PP2A 3
longitudinal muscle 1
Ppp2r1a (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 5 98.16 Very High Very High Very High
Dorsal horn neuron 40 97.48 Very High Very High Very High
Morphine 13 97.08 Very High Very High Very High
central sensitization 37 96.92 Very High Very High Very High
opioid receptor 1 94.84 High High
tetrodotoxin 2 93.84 High High
qutenza 64 93.56 High High
narcan 4 90.92 High High
Central nervous system 2 86.32 High High
Kinase C 1 85.92 High High
Disease Link Frequency Relevance Heat
Nociception 24 97.36 Very High Very High Very High
Stress 84 92.44 High High
Bordatella Infection 2 80.36 Quite High
Body Weight 4 76.04 Quite High
Cv Unclassified Under Development 105 68.00 Quite High
Hypoxia 18 63.92 Quite High
Cancer 18 8.48 Low Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 5 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The i.c.v. administration of very low doses of okadaic acid (0.001-1 pg/mouse) and cantharidin (0.001-1 ng/mouse), which inhibit PP2A, produced a dose-dependent antagonism of the antinociception induced by morphine (s.c.).
Negative_regulation (inhibit) of PP2A associated with antinociception and morphine
1) Confidence 0.48 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12650833 Disease Relevance 0 Pain Relevance 0.96
Additionally, the reported inhibition of PP2A activity by mTORC1 (43, 45, 46) could not be excluded.
Negative_regulation (inhibition) of PP2A in PP2A
2) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.19 Pain Relevance 0.03
We hypothesized that inhibition of PP2A-type activity induced by ROS produced during short term reperfusion could explain the increase in hyperphosphorylated 4E-BP1 at this time.
Negative_regulation (inhibition) of PP2A in PP2A
3) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.24 Pain Relevance 0.03
On the other hand, the increase in Thr308 and Ser473 phosphorylation in short term reperfusion could be explained by the inhibition of PP2A by ROS because PP2A has been described as an Akt phosphatase (47).
Negative_regulation (inhibition) of PP2A
4) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.09 Pain Relevance 0
To explore the role of protein phosphatase in central sensitization of spinal nociceptive neurons following peripheral noxious stimulation, using electrophysiological recording techniques, we investigated the role of two inhibitors of protein phosphatase type 2A (PP2A), fostriecin and okadaic acid (OA), on the responses of dorsal horn neurons to mechanical stimuli in anesthetized rats following intradermal injection of capsaicin.
Spec (investigated) Negative_regulation (inhibitors) of protein phosphatase type 2A in PP2A associated with nociception, qutenza, central sensitization and dorsal horn neuron
5) Confidence 0.03 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1559591 Disease Relevance 0.19 Pain Relevance 0.65
Inhibition of tyrosine phosphatases and serine/threonine phosphatases protein phosphatase 1 (PP1), PP2A, and PP2B did not prevent the inhibitory effect of NMDA.
Negative_regulation (Inhibition) of PP2A
6) Confidence 0.02 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11062237 Disease Relevance 0.15 Pain Relevance 0.31
Western and slot blot analyses of longitudinal muscle/myenteric plexus homogenates identified a significant reduction of the alpha3 but not the alpha1 subunit isoform in tolerant preparations.
Negative_regulation (reduction) of alpha1 subunit isoform in longitudinal muscle
7) Confidence 0.01 Published 2002 Journal Brain Res. Section Abstract Doc Link 11897105 Disease Relevance 0.08 Pain Relevance 0.43

General Comments

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