INT91863

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 9.43
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
endothelial cells 4
smooth muscle cells 4
tube 2
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 53 98.62 Very High Very High Very High
Inflammation 97 98.42 Very High Very High Very High
ischemia 11 97.68 Very High Very High Very High
Bioavailability 9 97.64 Very High Very High Very High
bradykinin 19 80.40 Quite High
reflex sympathetic dystrophy 21 79.08 Quite High
Angina 8 75.00 Quite High
COX-2 inhibitor 6 73.16 Quite High
rheumatoid arthritis 3 66.40 Quite High
cINOD 3 63.32 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 349 99.98 Very High Very High Very High
Hyperglycemia 71 99.70 Very High Very High Very High
Coronary Artery Disease 53 99.26 Very High Very High Very High
Nicotine Addiction 75 98.54 Very High Very High Very High
INFLAMMATION 98 98.42 Very High Very High Very High
Apoptosis 112 98.04 Very High Very High Very High
Pressure And Volume Under Development 9 97.76 Very High Very High Very High
Cardiovascular Disease 53 96.28 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

13 95.60 Very High Very High Very High
Insulin Resistance 80 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The suppressive mechanisms occur not only by pretranslational inhibition of eNOS expression but also by a posttranslational decrease in endothelial NO synthase activity due to a reduction in intracellular calcium levels.


Negative_regulation (inhibition) of Gene_expression (expression) of eNOS
1) Confidence 0.51 Published 2005 Journal Crit. Care Med. Section Body Doc Link 15891334 Disease Relevance 0 Pain Relevance 0
The functional importance of the diminished eNOS expression was revealed by the finding that serum nitrite/nitrate levels among individuals carrying the -786T-->C mutation were significantly lower than among those without the mutation.
Negative_regulation (diminished) of Gene_expression (expression) of eNOS
2) Confidence 0.47 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.35 Pain Relevance 0.14
Previous studies in animal models have suggested that there may be an inverse functional association between the two NOS isoforms within the vascular wall, with an up-regulation of nNOS when eNOS expression is reduced (Boulanger et al. 1998).
Negative_regulation (reduced) of Gene_expression (expression) of eNOS
3) Confidence 0.40 Published 2009 Journal Trends in Cardiovascular Medicine Section Body Doc Link PMC2984617 Disease Relevance 0.45 Pain Relevance 0.10
Could it be that one of the polygenic causes of T2DM involve the eNOS enzyme?
Negative_regulation (involve) of Gene_expression (enzyme) of eNOS associated with diabetes mellitus
4) Confidence 0.39 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.45 Pain Relevance 0.03
There is thus strong experimental evidence to support an important role for eNOS in the regulation of angiogenesis in animal models, however the implication of eNOS activity in collateral vessel formation in response to myocardial ischemia in humans remains unknown
Negative_regulation (implication) of Gene_expression (activity) of eNOS associated with coronary artery disease and ischemia
5) Confidence 0.37 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.58 Pain Relevance 0.17
In pathological situations circulating pro-inflammatory cytokines induce the expression of iNOS and ET-1 in smooth muscle cells, also downregulating endothelial eNOS expression, resulting in an elevated ET-1 production and a decrease of NO [18,39].
Negative_regulation (downregulating) of Gene_expression (expression) of eNOS in smooth muscle cells associated with inflammation and cytokine
6) Confidence 0.32 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.96 Pain Relevance 0.43
Mifepristone inhibited the endometrial glandular epithelial eNOS expression and did not affect the endothelilal eNOS.
Negative_regulation (inhibited) of Gene_expression (expression) of eNOS
7) Confidence 0.30 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.14 Pain Relevance 0
However, in vitro studies have shown that the smoking particles have many effects on endothelial and smooth muscle cells; eg, reduce prostacyclin release and eNOS expression in endothelial cells (Sun et al 1998), induce smooth muscle cell proliferation (Xu et al 1994) and enhance expression of vascular cell adhesion molecular (Chen et al 2004).
Negative_regulation (reduce) of Gene_expression (expression) of eNOS in smooth muscle cell associated with nicotine addiction and adhesions
8) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515430 Disease Relevance 0.76 Pain Relevance 0
In aortic endothelial cells, the hyperglycemia induced increased mitochondrial superoxide production and prevented eNOS activity and expression [88].
Negative_regulation (prevented) of Gene_expression (expression) of eNOS in endothelial cells associated with hyperglycemia
9) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.70 Pain Relevance 0.03
The defective eNOS-driven NO synthesis causes insulin
Negative_regulation (defective) of Neg (NO) Gene_expression (synthesis) of eNOS
10) Confidence 0.20 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.49 Pain Relevance 0.03
Hyperglycemia significantly reduces eNOS production by EPCs with a corresponding decline in nitric oxide (NO) bioavailability [31].
Negative_regulation (reduces) of Gene_expression (production) of eNOS associated with hyperglycemia and bioavailability
11) Confidence 0.19 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.64 Pain Relevance 0.05
Curcumin inhibition of endothelial nitric oxide synthase (eNOS) expression in endothelial cells has been shown to contribute to impaired endothelial tube formation.39 Taken together, our results suggest that the antiangiogenic activity of curcumin involves modulation of multiple pathways in endothelial cells.
Negative_regulation (inhibition) of Gene_expression (expression) of eNOS in tube
12) Confidence 0.17 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 0.67 Pain Relevance 0.20
PPAR- is expressed in endothelial cells, and its ligands have been reported to enhance NO production, possibly by stimulating the PI3K pathway and hence expression of eNOS (Kim et al 2002).
Negative_regulation (stimulating) of Gene_expression (expression) of eNOS in endothelial cells
13) Confidence 0.13 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.89 Pain Relevance 0.07
Serum from CAD patients was found to significantly downregulate eNOS protein expression and activity versus that of healthy controls (p < 0.01), most probably as a result of upregulation of tissue ACE.
Spec (probably) Negative_regulation (downregulate) of Gene_expression (expression) of eNOS associated with coronary artery disease
14) Confidence 0.05 Published 2009 Journal Drugs Section Abstract Doc Link 19275271 Disease Relevance 1.25 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox