INT91864

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.41
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
coronary artery 2
HeLa 2
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 7 97.48 Very High Very High Very High
Glutamate 3 33.88 Quite Low
ischemia 4 16.44 Low Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 6 98.56 Very High Very High Very High
Myocardial Infarction 3 98.12 Very High Very High Very High
Spasticity 6 97.80 Very High Very High Very High
Cv General 3 Under Development 7 97.48 Very High Very High Very High
Heart Rate Under Development 1 51.72 Quite High
Hypertension 2 47.52 Quite Low
Cardiovascular Disease 3 46.76 Quite Low
Disease 2 28.56 Quite Low
Cv Unclassified Under Development 3 6.80 Low Low
Coronary Heart Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RPA1 thus apparently functions as a repressor protein in the -786T-->C mutation-related reduction of eNOS gene transcription associated with the development of coronary artery disease.
Negative_regulation (reduction) of Transcription (transcription) of eNOS gene in coronary artery associated with coronary artery disease
1) Confidence 0.54 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.42 Pain Relevance 0.13
To elucidate the molecular mechanism for the reduced eNOS gene transcription, we have now purified a protein that specifically binds to the mutant allele in nuclear extracts from HeLa cells.
Negative_regulation (reduced) of Transcription (transcription) of eNOS gene in HeLa
2) Confidence 0.54 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.44 Pain Relevance 0.17
It has been shown that the rarer variant (C) suppresses eNOS transcription by approximately 50%.
Negative_regulation (suppresses) of Transcription (transcription) of eNOS
3) Confidence 0.51 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.11 Pain Relevance 0
We recently reported that a mutation (-786T-->C) in the promoter region of the endothelial nitric oxide synthase (eNOS) gene reduced transcription of the gene and was strongly associated with coronary spastic angina and myocardial infarction.
Negative_regulation (reduced) of Transcription (transcription) of eNOS associated with angina, spasticity and myocardial infarction
4) Confidence 0.40 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.44 Pain Relevance 0.17

General Comments

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