INT91869

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 6.81
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
endothelial cells 3
coronary artery 1
HeLa 1
sensory nerves 1
organ system 1
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 3 99.64 Very High Very High Very High
cINOD 24 98.74 Very High Very High Very High
cytokine 12 98.26 Very High Very High Very High
Angina 11 97.48 Very High Very High Very High
qutenza 3 93.24 High High
Inflammation 15 92.40 High High
ischemia 16 91.28 High High
COX2 8 88.08 High High
diclofenac 4 82.40 Quite High
Hyperalgesia 2 80.88 Quite High
Disease Link Frequency Relevance Heat
Necrosis 3 98.74 Very High Very High Very High
Disease 33 98.56 Very High Very High Very High
Coronary Artery Disease 15 98.56 Very High Very High Very High
Cancer 5 98.56 Very High Very High Very High
Spasticity 10 97.80 Very High Very High Very High
Myocardial Infarction 4 97.80 Very High Very High Very High
Cv General 3 Under Development 11 97.48 Very High Very High Very High
Hypertension 14 97.36 Very High Very High Very High
Hypoxia 1 96.40 Very High Very High Very High
Diabetes Mellitus 97 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To elucidate the molecular mechanism for the reduced eNOS gene transcription, we have now purified a protein that specifically binds to the mutant allele in nuclear extracts from HeLa cells.
Transcription (transcription) of eNOS gene in HeLa
1) Confidence 0.67 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.44 Pain Relevance 0.17
RPA1 thus apparently functions as a repressor protein in the -786T-->C mutation-related reduction of eNOS gene transcription associated with the development of coronary artery disease.
Transcription (transcription) of eNOS gene in coronary artery associated with coronary artery disease
2) Confidence 0.67 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.41 Pain Relevance 0.13
We recently reported that a mutation (-786T-->C) in the promoter region of the endothelial nitric oxide synthase (eNOS) gene reduced transcription of the gene and was strongly associated with coronary spastic angina and myocardial infarction.
Transcription (transcription) of eNOS associated with angina, spasticity and myocardial infarction
3) Confidence 0.64 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.44 Pain Relevance 0.17
Chromosome number 7 contains the vascular eNOS gene that encodes the transcription and synthesis of the 1203 amino acid protein enzyme eNOS. eNOS is located uniquely within caveolae of the plasma membrane which allows the monolayer of endothelial cells to compensate if its fellow cellmates become dysfunctional in order to maintain eNO production.
Transcription (transcription) of eNOS in endothelial cells
4) Confidence 0.63 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.27 Pain Relevance 0.03
Once conceptualized, that a specific and unique gene (eNOS, iNOS, nNOS) encodes the transcription of NO in a specific organ system, the opposing faces of this highly specialized, small, bioactive, and readily diffusible gas NO can be better understood (table 2, 3) [13].
Transcription (transcription) of eNOS in organ system
5) Confidence 0.63 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 0.92 Pain Relevance 0.03
It has been shown that the rarer variant (C) suppresses eNOS transcription by approximately 50%.
Transcription (transcription) of eNOS
6) Confidence 0.62 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1239913 Disease Relevance 0.11 Pain Relevance 0
The change in eNOS mRNA from baseline was highly correlated with the change in the expression of PPARGC1A and SIRT1 in the CR group (r = 0.86, p < 0.001 and r = 0.80, p < 0.001, respectively; unpublished data), suggesting synergistic regulation among PPARGC1A, SIRT1, and eNOS.
Transcription (change) of eNOS
7) Confidence 0.52 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.07 Pain Relevance 0
RPA1 was similarly detected in placenta and eNOS mRNA levels in placentas carrying the -786T-->C mutation were significantly lower than in placentas without it.
Transcription (levels) of eNOS in placenta
8) Confidence 0.49 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 11063722 Disease Relevance 0.37 Pain Relevance 0.15
The current study was designed to test the effect of coxibs and nonselective NSAIDs on vascular superoxide and nitric oxide (NO) production. mRNA expression of endothelial NO synthase (eNOS) and of the vascular NADPH oxidases was studied in spontaneously hypertensive rats (SHR) and in human endothelial cells.
Transcription (expression) of eNOS in endothelial cells associated with hypertension and cinod
9) Confidence 0.45 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.34 Pain Relevance 0.69
The current study was designed to test the effect of coxibs and nonselective NSAIDs on vascular superoxide and nitric oxide (NO) production. mRNA expression of endothelial NO synthase (eNOS) and of the vascular NADPH oxidases was studied in spontaneously hypertensive rats (SHR) and in human endothelial cells.
Transcription (expression) of endothelial NO synthase in endothelial cells associated with hypertension and cinod
10) Confidence 0.45 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.34 Pain Relevance 0.69
Propofol also reduced the LPS-enhanced iNOS mRNA and NF-kappaB protein levels whilst it increased eNOS mRNA expression (P < 0.05).
Transcription (expression) of eNOS
11) Confidence 0.35 Published 2006 Journal Inflamm. Res. Section Body Doc Link 17122960 Disease Relevance 0 Pain Relevance 0
is known to decrease eNOS mRNA levels by increasing the rate of mRNA degradation [18,19].
Transcription (levels) of eNOS
12) Confidence 0.34 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 1.22 Pain Relevance 0.33
The aim of the present study was (1) to investigate the effect of acylated ghrelin on the formation and healing of acute gastric mucosal lesions induced by ischemia-reperfusion and gastric mucosal blood flow in rats; (2) to analyse the effects of the deactivation of afferent sensory nerves with capsaicin and of the inhibition of nitric oxide (NO)-synthase by NG-nitro-l-arginine (l-NNA) on the ghrelin-induced protection; (3) to examine the influence of ghrelin on nuclear factor-kappa B (NF-kappaB) activation and on release of proinflammatory cytokines, such as tumor necrosis factor-alpha, (4) to assess the effect of ghrelin on the mRNA expression of constitutive nitric oxide synthase (cNOS), calcitonin gene related peptide (CGRP) and angiogenesis related proteins such as hypoxia inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF), and (5) to determine the effect of ischemia/reperfusion on the gastric mucosa expression of ghrelin in rats without and with administration of exogenous hormone.
Transcription (expression) of constitutive nitric oxide synthase in sensory nerves associated with calcitonin gene related peptide, necrosis, qutenza, hypoxia, cancer, ischemia and cytokine
13) Confidence 0.03 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16581065 Disease Relevance 0.88 Pain Relevance 0.46

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