INT91887

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.01
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Pik3cg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 16 98.44 Very High Very High Very High
central sensitization 2 97.76 Very High Very High Very High
Spinal cord 8 96.88 Very High Very High Very High
Kinase C 4 96.08 Very High Very High Very High
analgesia 2 92.80 High High
antagonist 7 90.52 High High
member 8 2 89.80 High High
addiction 14 86.96 High High
medulla 1 86.84 High High
agonist 13 85.96 High High
Disease Link Frequency Relevance Heat
Necrosis 30 99.48 Very High Very High Very High
Aids-related Complex 12 99.12 Very High Very High Very High
Hypersensitivity 16 97.72 Very High Very High Very High
Neointima 44 96.44 Very High Very High Very High
Injury 66 94.84 High High
Stress 52 90.52 High High
Hyperglycemia 8 76.00 Quite High
Pain 5 75.00 Quite High
Natriuresis 2 75.00 Quite High
Obesity 9 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (inhibitor) of PI3K associated with qutenza and hypersensitivity
1) Confidence 0.41 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.48 Pain Relevance 0.88
Effects of PI3K or MEK inhibitors on Akt-mTOR-P70S6K in RAoSMCs treated with rosiglitazone
Negative_regulation (inhibitors) of PI3K
2) Confidence 0.34 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 1.09 Pain Relevance 0.04
Two structurally unrelated phosphoinositide 3-Kinase (PI3K, upstream of PKB/Akt) inhibitors, Wortmannin and LY294002, also prevented the mechanical hypersensitivity induced by intradermal injection of capsaicin.
Negative_regulation (inhibitors) of PI3K associated with qutenza and hypersensitivity
3) Confidence 0.30 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.49 Pain Relevance 0.89
U73122, a phospholipase C (PLC) inhibitor, or wortmannin, a phosphatidyl inositol 3'-kinase (PI3K) inhibitor, significantly reduced the PAR-1-mediated contraction, but not the relaxation, by itself, as the PKC inhibitor GF109203X and the TK inhibitor genistein did.
Negative_regulation (inhibitor) of PI3K associated with kinase c
4) Confidence 0.27 Published 2000 Journal Life Sci. Section Abstract Doc Link 11065174 Disease Relevance 0 Pain Relevance 0.28
In both control and hyperleptinemic groups the effect of leptin on Na(+) excretion and renal Na(+),K(+)-ATPase was abolished by phosphoinositide 3-kinase (PI3K) inhibitor, wortmannin, but not by protein kinase B/Akt inhibitor, triciribine,.
Negative_regulation (inhibitor) of PI3K
5) Confidence 0.26 Published 2010 Journal Peptides Section Abstract Doc Link 19854228 Disease Relevance 0.39 Pain Relevance 0.13
It is also known that wortmannin is a PI3K inhibitor and U0126 inhibits MEK1/2 activation.
Negative_regulation (inhibitor) of PI3K
6) Confidence 0.25 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.49 Pain Relevance 0
Inhibition of both MEK and PI3K resulted in partial reduction of p-P70S6K expression that was associated with additional inhibition, indicating that both the MAPK and PI3K pathways have an effect on the activation of the Akt-mTOR-P70S6K system.


Negative_regulation (Inhibition) of PI3K
7) Confidence 0.25 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.45 Pain Relevance 0.03
Furthermore, release was partially reduced by phosphoinositol-3-kinase (PI3K) inhibitors.
Negative_regulation (inhibitors) of PI3K
8) Confidence 0.23 Published 2006 Journal FASEB J. Section Abstract Doc Link 17060402 Disease Relevance 0.33 Pain Relevance 1.10
Müller-derived rMC-1 cells were treated with 400 µM H2O2 together with 1 µM SERPINA3K, 250 nM U73122 (PLC inhibitor), 10 µM U0126 (ERK inhibitor) or 100 nM Wortmannin (PI3K inhibitor).
Negative_regulation (inhibitor) of PI3K
9) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605247 Disease Relevance 0.15 Pain Relevance 0
To identify the pathway involved in the H2O2-induced necrosis in rMC-1 cells, specific inhibitors for ERK, PI3K and PLC were used.
Negative_regulation (inhibitors) of PI3K associated with necrosis
10) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605247 Disease Relevance 0.46 Pain Relevance 0.04
Fig. 5 shows the effect of inhibition of the MEK/ERK and PI3K pathways on the effect of rosiglitazone treatment.
Negative_regulation (inhibition) of PI3K
11) Confidence 0.11 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.52 Pain Relevance 0
In contrast, inhibitors of nitric oxide synthase (NOS), phosphotidylinositol-3-kinase (PI3K), and CAMK exhibited less prevalent, gene-specific effects on BDNF-induced RNA expression.
Negative_regulation (inhibitors) of PI3K
12) Confidence 0.07 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2669182 Disease Relevance 0.06 Pain Relevance 0.22
BDNF-mediated induction of Egr1 and Dusp6 were blocked by either MEK or PI3K inhibition.
Negative_regulation (inhibition) of PI3K
13) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.10 Pain Relevance 0.06

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