INT91890

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 25.44
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
mast cell 4
smooth muscle 2
blood 1
macrophage 1
cardiac myocyte 1
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 99.96 Very High Very High Very High
spastic colon 2 97.48 Very High Very High Very High
Chronic pancreatitis 10 94.84 High High
Inflammation 108 94.24 High High
abdominal pain 17 93.84 High High
Bile 9 93.58 High High
cytokine 72 93.20 High High
Dismenorea 4 87.40 High High
fibrosis 3 85.88 High High
imagery 23 85.36 High High
Disease Link Frequency Relevance Heat
Myeloid Leukemia 92 100.00 Very High Very High Very High
Leukemia 36 100.00 Very High Very High Very High
Gastrointestinal Stromal Tumor 489 99.98 Very High Very High Very High
Immunization 138 99.92 Very High Very High Very High
Dilated Cardiomyopathy 41 99.92 Very High Very High Very High
Gastroenteritis 2 99.88 Very High Very High Very High
Cancer 495 99.58 Very High Very High Very High
Rhinitis 17 99.56 Very High Very High Very High
Infection 106 98.98 Very High Very High Very High
Parasitic Infection 6 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accumulation of hepatic lipids in KitSco5/Sco5 mutants was detected at 2.5 dpp (Figure 3F) suggesting that defect started earlier.
Positive_regulation (Accumulation) of Sco5
1) Confidence 0.50 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.05 Pain Relevance 0
Accumulation of hepatic lipids in KitSco5/Sco5 mutants was detected at 2.5 dpp (Figure 3F) suggesting that defect started earlier.
Positive_regulation (Accumulation) of KitSco5
2) Confidence 0.50 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.05 Pain Relevance 0
Since phosphorylation of mTOR depends on KIT signaling in the imatinib-sensitive GISTs, RAD001 did not show any synergistic effect with imatinib in this setting.
Positive_regulation (depends) of KIT
3) Confidence 0.48 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.67 Pain Relevance 0
VN and SA generated the genetic mapping of the Sco5, Sco1, Sow3 and Whc1.
Positive_regulation (generated) of Sco5
4) Confidence 0.47 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0 Pain Relevance 0
Spleen cells were incubated with biotinylated anti–mouse B220, Gr-1, CD11b, CD11c, CD49b, Ter119, and c-kit for 20 min at 4°C.
Positive_regulation (biotinylated) of c-kit in Spleen
5) Confidence 0.46 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0
We then checked the potential KIT dependence of ex vivo contractile activity of the uterus by combining genetic and pharmacological approaches, using the Kit W-v hypomorphic mutation, and imatinib as a KIT noncompetitive inhibitor.
Positive_regulation (potential) of KIT in uterus associated with addiction
6) Confidence 0.44 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18480468 Disease Relevance 0.31 Pain Relevance 0.40
Mutations in this proto-oncogene commonly cause constitutive activation of the KIT tyrosine kinase receptor, an important factor in the pathogenesis of the disease.
Positive_regulation (activation) of KIT associated with disease
7) Confidence 0.42 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2503651 Disease Relevance 0.70 Pain Relevance 0
point mutation and protein activation, superimposed on the original mutation in that gene. 2) KIT genomic amplification with overexpression of the KIT oncoprotein, without a new point mutation. 3) Target modulation – activation of an alternate receptor tyrosine kinase protein, accompanied by loss of KIT oncoprotein expression. 4) Functional resistance – KIT or PDGFR?
Positive_regulation (overexpression) of KIT oncoprotein
8) Confidence 0.42 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.19 Pain Relevance 0
In neoplastic mast cell lines, valine or tyrosine substitution for an aspartate in c-kit codon 816 results in constitutive phosphorylation and activation of KIT[6].
Positive_regulation (activation) of KIT in mast cell
9) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2292130 Disease Relevance 0.62 Pain Relevance 0
Immunostaining of the tumor cells were strongly positive for CD117 and negative for S100, desmin, smooth muscle, and actin (Figure 8).
Positive_regulation (positive) of CD117 in smooth muscle associated with cancer
10) Confidence 0.39 Published 2010 Journal Cases J Section Body Doc Link PMC2836292 Disease Relevance 0.91 Pain Relevance 0
Four mechanisms of imatinib resistance were identified: 1) Target resistance due to mutation – a new KIT or PDGFR?
Positive_regulation (new) of KIT
11) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.20 Pain Relevance 0
But it is worth noting that positive staining for KIT does not necessarily indicate KIT activation or KIT mutation (Joensuu et al 2002).
Positive_regulation (activation) of KIT
12) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 1.12 Pain Relevance 0
But it is worth noting that positive staining for KIT does not necessarily indicate KIT activation or KIT mutation (Joensuu et al 2002).
Positive_regulation (activation) of KIT
13) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 1.11 Pain Relevance 0
The function of BCR-ABL has allowed the design and development of imatinib, a small-molecule kinase inhibitor that targets PDGFR, c-Kit, and ABL kinases (Deininger et al 2005).
Positive_regulation (targets) of c-Kit
14) Confidence 0.31 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 1.11 Pain Relevance 0.05
Immunohistochemistry showed positive staining of the neoplastic cells for cytokeratin and focally positive staining for CD10 and CD117 (c-Kit).
Positive_regulation (staining) of CD117
15) Confidence 0.30 Published 2005 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 16048402 Disease Relevance 1.03 Pain Relevance 0.12
The cells were then trypsinized for 1 minute, centrifuged, washed with PBS, fixed in 4% paraformaldehyde for 0.5 hour at room temperature, washed and blocked in 2%FCS for 0.5 hour at room temperature with agitation. 1.5×105cells were then incubated with each of the following conjugated monoclonal antibodies: Tie-2, Flk-1, CD34, c-Kit, Thy-1, Sca-1 (PharMingen, San Diego, CA) for 90 mins at room temperature.
Positive_regulation (incubated) of c-Kit
16) Confidence 0.28 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.24 Pain Relevance 0.06
Peritoneal lavage was performed and the recovered cells contained a distinct population of CD117+/Fc?
Positive_regulation (population) of CD117
17) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0 Pain Relevance 0.07
VN and SA generated the genetic mapping of the Sco5, Sco1, Sow3 and Whc1.
Positive_regulation (generated) of Sow3
18) Confidence 0.21 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0 Pain Relevance 0
Seventeen GI biopsies from 6 patients with SM; 17 GI biopsies from 5 patients with UP; and 157 control cases including 10 each normal stomach, duodenum, terminal ileum, and colon, Helicobacter pylori gastritis, bile reflux gastropathy, peptic duodenitis, celiac disease, Crohn disease, ulcerative colitis, lymphocytic colitis, and collagenous colitis, 20 biopsies from 16 patients with irritable bowel syndrome, 8 biopsies from 5 patients with parasitic infections, and 9 biopsies from 7 patients with eosinophilic gastroenteritis were immunostained for mast cell tryptase, c-kit (CD117), and CD25.
Positive_regulation (immunostained) of CD117 in mast cell associated with bile, crohn's disease, spastic colon, gastroenteritis, duodenitis, rhinitis, parasitic infection, celiac disease, collagenous colitis, lymphocytic colitis, systemic mastocytosis, urticaria pigmentosa and gastritis
19) Confidence 0.20 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 2.42 Pain Relevance 0.24
Seventeen GI biopsies from 6 patients with SM; 17 GI biopsies from 5 patients with UP; and 157 control cases including 10 each normal stomach, duodenum, terminal ileum, and colon, Helicobacter pylori gastritis, bile reflux gastropathy, peptic duodenitis, celiac disease, Crohn disease, ulcerative colitis, lymphocytic colitis, and collagenous colitis, 20 biopsies from 16 patients with irritable bowel syndrome, 8 biopsies from 5 patients with parasitic infections, and 9 biopsies from 7 patients with eosinophilic gastroenteritis were immunostained for mast cell tryptase, c-kit (CD117), and CD25.
Positive_regulation (immunostained) of c-kit in mast cell associated with bile, crohn's disease, spastic colon, gastroenteritis, duodenitis, rhinitis, parasitic infection, celiac disease, collagenous colitis, lymphocytic colitis, systemic mastocytosis, urticaria pigmentosa and gastritis
20) Confidence 0.20 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 2.42 Pain Relevance 0.24

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