INT91891

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 10
Speculated 2
Reported most in Body
Documents 268
Total Number 270
Disease Relevance 158.89
Pain Relevance 22.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Anatomy Link Frequency
epidermis 14
mast cells 9
interstitial cells 7
liver 5
stem cell 5
Kit (Mus musculus)
Kit - D816V (1) Kit - V654A (1)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 877 100.00 Very High Very High Very High
Calcitonin gene-related peptide 48 100.00 Very High Very High Very High
addiction 8 99.96 Very High Very High Very High
Spinal cord 135 99.88 Very High Very High Very High
COX2 2 99.64 Very High Very High Very High
Somatostatin 4 99.56 Very High Very High Very High
chemokine 155 99.36 Very High Very High Very High
substance P 101 99.28 Very High Very High Very High
qutenza 35 99.06 Very High Very High Very High
spastic colon 385 98.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 879 100.00 Very High Very High Very High
Sprains And Strains 267 100.00 Very High Very High Very High
Cancer 5331 99.98 Very High Very High Very High
Gastrointestinal Stromal Tumor 3749 99.98 Very High Very High Very High
Targeted Disruption 396 99.86 Very High Very High Very High
Muscle Tissue Neoplasms 6 99.82 Very High Very High Very High
Anaemia 208 99.80 Very High Very High Very High
Uterine Fibroids 103 99.54 Very High Very High Very High
Rhinitis 134 99.40 Very High Very High Very High
Renal Cancer 15 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kit expression was detected in a large number of cells in the liver from 0.5 to 2.5 dpp, as a reminiscence of fetal hematopoiesis (Figure 5A).
Gene_expression (expression) of Kit in liver associated with hematological disease
1) Confidence 0.78 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.30 Pain Relevance 0
Consistent with the phenotype, Kit gene expression was detected during post-natal development in the liver by using the lacZ reporter gene inserted in the first exon of Kit from the Kittm1Alf/+ mouse [8].
Gene_expression (expression) of Kit in liver
2) Confidence 0.78 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.31 Pain Relevance 0
Based on several features, including KIT expression and KIT dependence, ICC-like cells were identified in nongastrointestinal tissues.
Gene_expression (expression) of KIT associated with addiction
3) Confidence 0.78 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 18480468 Disease Relevance 0.16 Pain Relevance 0.25
These tumors are identified by expression of CD117 or CD34 antigen.
Gene_expression (expression) of CD117
4) Confidence 0.77 Published 2008 Journal J Egypt Natl Canc Inst Section Abstract Doc Link 19847285 Disease Relevance 0.94 Pain Relevance 0.10
After stem cell kinase receptor CD117 (c-Kit) was introduced, the GISTs presumed to derive from stem cells differentiating to the GI pacemaker cells, known as interstitial cells of Cajal (ICC), because nearly all GISTs are implicated with c-Kit gene abnormality and CD117 (c-Kit) overexpression (1).
Gene_expression (overexpression) of Kit in interstitial cells
5) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.32 Pain Relevance 0.03
After stem cell kinase receptor CD117 (c-Kit) was introduced, the GISTs presumed to derive from stem cells differentiating to the GI pacemaker cells, known as interstitial cells of Cajal (ICC), because nearly all GISTs are implicated with c-Kit gene abnormality and CD117 (c-Kit) overexpression (1).
Gene_expression (overexpression) of CD117 in interstitial cells
6) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.32 Pain Relevance 0.03
The exceptions were very clearly described in the paper of Christopher et al.; including fixation artifact, technical error of immunostaining, sampling error, cessation of Kit expression perhaps following STI-571 therapy and very rare cases (2%) with real lack of Kit mutation and/or Kit expression (15).
Gene_expression (expression) of Kit
7) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 1.31 Pain Relevance 0
Tumors of our cases also showed variable histology, but immunohistochemically, our cases were compatible with GISTs or GANTs based on expression of vimentin (100%), CD117 (100%), and CD34 (66.7%).
Gene_expression (expression) of CD117 associated with cancer
8) Confidence 0.77 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 0.91 Pain Relevance 0
g of total RNA were subsequently used to synthesize cDNA using the First Strand cDNA synthesis kit (Roche, Switzerland).
Gene_expression (synthesize) of kit
9) Confidence 0.75 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.88 Pain Relevance 0.14
The proliferation of the KIT-expressing and imatinib-sensitive and KIT-expressing but imatinib-resistant cell lines was inhibited by 17-AAG, but that of the KIT-non-expressing and imatinib-resistant cell line was not.
Gene_expression (expressing) of KIT
10) Confidence 0.75 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.57 Pain Relevance 0
The proliferation of the KIT-expressing and imatinib-sensitive and KIT-expressing but imatinib-resistant cell lines was inhibited by 17-AAG, but that of the KIT-non-expressing and imatinib-resistant cell line was not.
Gene_expression (expressing) of KIT
11) Confidence 0.75 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.56 Pain Relevance 0
Gastrointestinal stromal tumors of the small intestine that expressed c-kit protein.
Gene_expression (expressed) of c-kit protein in small intestine associated with gastrointestinal stromal tumor
12) Confidence 0.74 Published 2000 Journal Intern. Med. Section Title Doc Link 11065242 Disease Relevance 0.88 Pain Relevance 0.08
We report two patients with gastrointestinal stromal tumors (GISTs) of the small intestine that expressed c-kit protein (CD117).
Gene_expression (expressed) of c-kit protein in small intestine associated with gastrointestinal stromal tumor
13) Confidence 0.74 Published 2000 Journal Intern. Med. Section Abstract Doc Link 11065242 Disease Relevance 0.82 Pain Relevance 0.08
We report two patients with gastrointestinal stromal tumors (GISTs) of the small intestine that expressed c-kit protein (CD117).
Gene_expression (expressed) of CD117 in small intestine associated with gastrointestinal stromal tumor
14) Confidence 0.74 Published 2000 Journal Intern. Med. Section Abstract Doc Link 11065242 Disease Relevance 0.82 Pain Relevance 0.08
The immunohistochemical detection of the protein CD 117 (c-kit) is an important diagnostic tool.
Gene_expression (detection) of c-kit
15) Confidence 0.73 Published 2006 Journal Med. Klin. (Munich) Section Abstract Doc Link 16418817 Disease Relevance 1.35 Pain Relevance 0.11
point mutation and protein activation, superimposed on the original mutation in that gene. 2) KIT genomic amplification with overexpression of the KIT oncoprotein, without a new point mutation. 3) Target modulation – activation of an alternate receptor tyrosine kinase protein, accompanied by loss of KIT oncoprotein expression. 4) Functional resistance – KIT or PDGFR?
Gene_expression (overexpression) of KIT oncoprotein
16) Confidence 0.69 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.19 Pain Relevance 0
KIT overexpression is common in a variety of tumor types including GISTs, seminomas, adenoid cystic carcinomas, malignant melanomas, and lung carcinomas (non-small cell and small cell types) (Takahashi et al 1995; Went et al 2004).
Gene_expression (overexpression) of KIT in lung associated with seminoma, lung cancer, melanoma, cancer and adenoid cystic carcinoma
17) Confidence 0.69 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.98 Pain Relevance 0
The KIT proto-oncogene on chromosome 4 (4q11–q12) encodes for the KIT protein, which is also expressed on mast cells, germ cells, and hemopoietic cells.
Gene_expression (expressed) of KIT in hemopoietic cells
18) Confidence 0.69 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503651 Disease Relevance 0.61 Pain Relevance 0
Thereafter, Kit expression was confined to a few cells located in the hepatic parenchyma and was also found in the epithelial cells of the biliary canals at later stages and in adults.
Gene_expression (expression) of Kit in canals
19) Confidence 0.68 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.29 Pain Relevance 0
Consistently, KIT and KITL were found to be expressed in the rat cholangiocytes [9] and several mouse mutants of Kitl displayed comparable low post-natal viability [46,47].


Gene_expression (expressed) of KIT
20) Confidence 0.68 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.37 Pain Relevance 0

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