INT91906

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 3
Speculated 7
Reported most in Body
Documents 13
Total Number 19
Disease Relevance 8.92
Pain Relevance 7.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
sciatic nerve 4
brain 4
Plasma 2
nerve 2
Schwann cells 2
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 229 100.00 Very High Very High Very High
Inflammation 137 100.00 Very High Very High Very High
fluoxetine 3 100.00 Very High Very High Very High
acular 3 99.86 Very High Very High Very High
Morphine 13 99.84 Very High Very High Very High
rheumatoid arthritis 4 99.32 Very High Very High Very High
Sciatic nerve 59 99.12 Very High Very High Very High
Neuropathic pain 44 98.92 Very High Very High Very High
depression 6 98.24 Very High Very High Very High
Arthritis 5 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 169 100.00 Very High Very High Very High
Sepsis 37 99.90 Very High Very High Very High
Rheumatoid Arthritis 4 99.32 Very High Very High Very High
Periodontal Disease 10 99.24 Very High Very High Very High
Nociception 4 98.96 Very High Very High Very High
Neuropathic Pain 82 98.92 Very High Very High Very High
Depression 6 98.24 Very High Very High Very High
Experimental Arthritis 3 98.08 Very High Very High Very High
Necrosis 12 97.86 Very High Very High Very High
Cancer 12 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since thalidomide mainly inhibits tumor necrosis factor alpha (TNF-alpha) synthesis with less well defined effects on other cytokines, we investigated the effect of the drug on the expression of the proinflammatory cytokines TNF-alpha, interleukin-1beta (IL-1beta) and interleukin 6 (IL-6), and of the anti-inflammatory cytokine interleukin-10 (IL-10) in the lesioned rat sciatic nerve.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of IL-10 in sciatic nerve associated with necrosis, inflammation, cancer, sciatic nerve and cytokine
1) Confidence 0.58 Published 2000 Journal Pain Section Abstract Doc Link 11068114 Disease Relevance 1.05 Pain Relevance 0.65
Betamethasone may act by regulating the expression of NF-kappaB, TNFalpha, IL-1beta and IL-10 in the brain.
Regulation (regulating) of Gene_expression (expression) of IL-10 in brain
2) Confidence 0.57 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.84 Pain Relevance 0.88
and IL-10 protein levels in DRG heteronymous to injured nerve
Regulation (heteronymous) of Gene_expression (levels) of IL-10 in nerve
3) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.82 Pain Relevance 0.42
and IL-10 protein levels in DRG of sham-operated rats
Regulation (operated) of Gene_expression (levels) of IL-10
4) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.47 Pain Relevance 0.24
Since thalidomide mainly inhibits tumor necrosis factor alpha (TNF-alpha) synthesis with less well defined effects on other cytokines, we investigated the effect of the drug on the expression of the proinflammatory cytokines TNF-alpha, interleukin-1beta (IL-1beta) and interleukin 6 (IL-6), and of the anti-inflammatory cytokine interleukin-10 (IL-10) in the lesioned rat sciatic nerve.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of anti-inflammatory cytokine interleukin-10 in sciatic nerve associated with necrosis, inflammation, cancer, sciatic nerve and cytokine
5) Confidence 0.37 Published 2000 Journal Pain Section Abstract Doc Link 11068114 Disease Relevance 1.05 Pain Relevance 0.63
Infiltrating hematogenous macrophages are probably partially responsible for the high IL-10 expression noted at day 21 in the distal epi-/perineurium, and in the endoneurium this expression would be augmented by Schwann cells [20,36].
Spec (probably) Regulation (responsible) of Gene_expression (expression) of IL-10 in Schwann cells
6) Confidence 0.34 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1310517 Disease Relevance 0.39 Pain Relevance 0.09
In this study, we examined whether oral administration of BLF causes anti-nociceptive and anti-inflammatory effects, and also whether it modulates LPS-induced TNF-alpha and IL-10 production in rat model of rheumatoid arthritis (RA), rat adjuvant arthritis.
Spec (whether) Regulation (modulates) of Gene_expression (production) of IL-10 associated with nociception, inflammation, rheumatoid arthritis, experimental arthritis and arthritis
7) Confidence 0.30 Published 2004 Journal J. Vet. Med. Sci. Section Abstract Doc Link 15031542 Disease Relevance 0.99 Pain Relevance 0.69
In contrast, morphine did not alter expression of the anti-inflammatory cytokine interleukin-10.
Neg (not) Regulation (alter) of Gene_expression (expression) of anti-inflammatory cytokine interleukin-10 associated with inflammation, cytokine and morphine
8) Confidence 0.27 Published 2001 Journal Clin. Immunol. Section Abstract Doc Link 11237561 Disease Relevance 0.58 Pain Relevance 0.80
Considering possible haplotypes, each polymorphism may contribute to the production of IL-10 differently and specific haplotypes may influence in progression of periodontal disease [28, 29].
Spec (may) Regulation (influence) of Gene_expression (production) of IL-10 associated with periodontal disease
9) Confidence 0.25 Published 2009 Journal The Open Dentistry Journal Section Body Doc Link PMC2745565 Disease Relevance 0.41 Pain Relevance 0.03
Expression of IL-10, IL-1beta, and TNF-alpha was likewise unaltered.
Regulation (unaltered) of Gene_expression (Expression) of IL-10
10) Confidence 0.17 Published 2010 Journal Peptides Section Abstract Doc Link 19799952 Disease Relevance 0.14 Pain Relevance 0.25
RESULTS: Placental production of IL-10 was not affected by clonidine, but decreased significantly after incubation of the tissue with diazoxide, hydralazine or furosemide.
Neg (not) Regulation (affected) of Gene_expression (production) of IL-10
11) Confidence 0.17 Published 2006 Journal J. Hypertens. Section Body Doc Link 16612254 Disease Relevance 0.06 Pain Relevance 0
The abundance of Tregs in Hawthorn-treated brain following I/R may have influenced the increased expression of IL-10.
Spec (may) Regulation (influenced) of Gene_expression (expression) of IL-10 in brain
12) Confidence 0.15 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.38 Pain Relevance 0.27
PGE2 may exert anti-inflammatory effect via its influence on IL-10 production [36].
Regulation (influence) of Gene_expression (production) of IL-10 associated with inflammation
13) Confidence 0.12 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.44 Pain Relevance 0.22
OBJECTIVE: To examine the effect of pharmaceutical doses of well known antihypertensive drugs used for blood pressure control on the production of the cytokines interleukin (IL)-6, IL-10 and tumour necrosis factor (TNF)-alpha in placental tissue and peripheral blood mononuclear cells (PBMCs) in normal pregnancy.
Regulation (control) of Gene_expression (production) of IL-10 in mononuclear cells
14) Confidence 0.12 Published 2006 Journal J. Hypertens. Section Body Doc Link 16612254 Disease Relevance 0.09 Pain Relevance 0
In this study we have shown that the use of EN compared with PN in rats with abdominal sepsis can influence serum levels of IL-6 and IL-10.
Regulation (influence) of Gene_expression (levels) of IL-10 associated with sepsis and cytokine
15) Confidence 0.11 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.51 Pain Relevance 0.08
Plasma levels of interleukin-6 and interleukin-10 are affected by ketorolac as an adjunct to patient-controlled morphine after abdominal hysterectomy.
Regulation (affected) of Gene_expression (levels) of interleukin-10 in Plasma associated with acular and morphine
16) Confidence 0.11 Published 2001 Journal Clin J Pain Section Title Doc Link 11289091 Disease Relevance 0 Pain Relevance 1.09
This study was carried out to examine the effects of antidepressive agents, i.e., imipramine, venlafaxine, L-5-hydroxytryptophan, and fluoxetine on the production of interferon-gamma (IFN-gamma), a proinflammatory cytokine, and interleukin-10 (IL-10), a negative immunoregulatory cytokine.
Spec (examine) Regulation (effects) of Gene_expression (production) of IL-10 associated with cytokine and fluoxetine
17) Confidence 0.08 Published 2001 Journal J Clin Psychopharmacol Section Abstract Doc Link 11270917 Disease Relevance 0.63 Pain Relevance 0.73
The dose effect of drugs on the production of placental and circulating cytokines (IL-6, IL-10 and TNF-alpha) were examined by enzyme-linked immunosorbent assay.
Regulation (effect) of Gene_expression (production) of IL-10
18) Confidence 0.07 Published 2006 Journal J. Hypertens. Section Body Doc Link 16612254 Disease Relevance 0.07 Pain Relevance 0
No significant change in the production of TNFalpha and IL-10 upon in vitro stimulation of PBMCs with LPS was detectable during infliximab treatment.
Neg (No) Regulation (change) of Gene_expression (production) of IL-10
19) Confidence 0.04 Published 2003 Journal Arthritis Rheum. Section Body Doc Link 12632433 Disease Relevance 0 Pain Relevance 0

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