INT91914

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.44
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn1) plasma membrane (Accn1)
Anatomy Link Frequency
spinal nerve 1
sensory neurons 1
mechanoreceptors 1
Accn1 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 5 100.00 Very High Very High Very High
Mechanosensation 1 97.56 Very High Very High Very High
Mechanotransduction 1 96.88 Very High Very High Very High
sodium channel 2 94.40 High High
nociceptor 5 91.92 High High
unmyelinated 2 90.44 High High
Root ganglion neuron 3 88.92 High High
qutenza 5 80.12 Quite High
Pain 1 46.84 Quite Low
Inflammation 1 45.88 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 88.60 High High
Sprains And Strains 1 78.88 Quite High
Nociception 3 75.00 Quite High
Pain 1 46.84 Quite Low
INFLAMMATION 1 45.88 Quite Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After spinal nerve ligation, ASIC2 and ASIC3 knockout mice developed mechanical and heat hyperalgesia comparable with that of their respective WT controls.
ASIC2 Binding (ligation) of in spinal nerve
1) Confidence 0.36 Published 2010 Journal Anesthesiology Section Body Doc Link 20693874 Disease Relevance 0 Pain Relevance 0
Here we show that disrupting the mouse BNC1 gene markedly reduces the sensitivity of a specific component of mechanosensation: low-threshold rapidly adapting mechanoreceptors.
BNC1 gene Binding (disrupting) of in mechanoreceptors associated with mechanosensation
2) Confidence 0.16 Published 2000 Journal Nature Section Abstract Doc Link 11069180 Disease Relevance 0 Pain Relevance 0.24
Together these findings indicate that there are significant differences between rat and mouse in the contribution of TRPV1 and ASIC subunits to proton sensitivity of sensory neurons.
ASIC Binding (contribution) of in sensory neurons associated with asic
3) Confidence 0.03 Published 2006 Journal Neuroscience Section Abstract Doc Link 16515841 Disease Relevance 0.44 Pain Relevance 1.00

General Comments

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