INT91916

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 51
Total Number 52
Disease Relevance 21.20
Pain Relevance 19.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 16
sensory neurons 3
nociceptors 3
C8-B4 3
IB4 2
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 638 100.00 Very High Very High Very High
dorsal root ganglion 104 100.00 Very High Very High Very High
Calcitonin gene-related peptide 34 100.00 Very High Very High Very High
bradykinin 24 100.00 Very High Very High Very High
c fibre 69 99.98 Very High Very High Very High
IPN 107 99.82 Very High Very High Very High
Trigeminal ganglion neurons 47 99.78 Very High Very High Very High
Pain 444 99.76 Very High Very High Very High
trigeminal ganglion 384 99.72 Very High Very High Very High
Nerve growth factor 87 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 642 100.00 Very High Very High Very High
Targeted Disruption 630 100.00 Very High Very High Very High
Inflammatory Pain 108 99.82 Very High Very High Very High
Pain 487 99.76 Very High Very High Very High
Injury 40 99.00 Very High Very High Very High
INFLAMMATION 217 98.88 Very High Very High Very High
Cancer 13 98.64 Very High Very High Very High
Nociception 169 98.56 Very High Very High Very High
Nervous System Injury 88 98.46 Very High Very High Very High
Migraine Disorders 118 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ATP receptor P2X3 is selectively expressed on small diameter sensory neurons, supporting this hypothesis.
Gene_expression (expressed) of P2X3 in sensory neurons
1) Confidence 0.78 Published 2000 Journal Nature Section Abstract Doc Link 11069181 Disease Relevance 0.61 Pain Relevance 0.32
It is also possible that RTX has prevented the ATP released from urothelial cells [2] and consequently the activation of sub-urothelial C-fibers expressing P2X3 receptors [15].
Gene_expression (expressing) of P2X3 in urothelial cells associated with c fibre
2) Confidence 0.75 Published 2007 Journal BMC Urol Section Body Doc Link PMC1903357 Disease Relevance 0.16 Pain Relevance 0.39
P2rx3:, a gene coding one of the P2 purinergic receptors, was almost exclusively expressed in small and medium sized neuronal profiles in naïve and operated mice with some variation among the strains in the percentage of neurons P2rx3-positive.
Gene_expression (expressed) of P2rx3 in neurons associated with sprains and strains
3) Confidence 0.72 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.40 Pain Relevance 0.56
Thus, our data indicate a major gain of function of P2X3 receptors without their concomitant overexpression at the plasma membrane or a larger number of P2X3 receptor expressing neurons.
Gene_expression (expressing) of P2X3 in neurons
4) Confidence 0.71 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.21 Pain Relevance 0.47
Although significant, this difference was not very large probably because the number of P2X3 receptor expressing neurons that also expressed CaV2.1 channels was less than 50% of the total population whose contribution diluted the overall change (see Fig. 3F).
Gene_expression (expressing) of P2X3 in neurons
5) Confidence 0.71 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
These studies demonstrate increased expression of P2X3 receptors on CGRP-ir ENFs during tumor growth and suggest a role for ATP in cancer-related pain.
Gene_expression (expression) of P2X3 associated with pain and cancer
6) Confidence 0.70 Published 2005 Journal Brain Res. Section Abstract Doc Link 15885218 Disease Relevance 0.81 Pain Relevance 0.30
Na(v)1.9 is present in nociceptor sensory neurons that express TRPV1, bradykinin B2, and purinergic P2X3 receptors.
Gene_expression (express) of P2X3 in sensory neurons associated with nociceptor and bradykinin
7) Confidence 0.66 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17167076 Disease Relevance 0.59 Pain Relevance 0.87
Interestingly, all OSMRbeta-positive neurons in these ganglia also expressed both TRPV1 (a vanilloid receptor) and P2X3 (a purinergic receptor).
Gene_expression (expressed) of P2X3 in ganglia
8) Confidence 0.66 Published 2005 Journal Anat Sci Int Section Abstract Doc Link 15794131 Disease Relevance 0.14 Pain Relevance 0.23
The ATP receptor P2X3 is selectively expressed by nociceptors and is one of seven ATP-gated, cation-selective ion channels.
Gene_expression (expressed) of ATP receptor P2X3 in nociceptors associated with nociceptor
9) Confidence 0.66 Published 2000 Journal Nature Section Abstract Doc Link 11069182 Disease Relevance 0.39 Pain Relevance 0.47
Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors.
Neg (lacking) Gene_expression (lacking) of P2X3 associated with inflammation and ipn
10) Confidence 0.65 Published 2000 Journal Nature Section Title Doc Link 11069182 Disease Relevance 0.57 Pain Relevance 0.75
This would be revealed by an increase in the sensitivity of the MMC to inhibition by mecamylamine in P2X3 KO mice because it has been shown that P2X3 subunits are expressed by murine colonic myenteric neurons (Ruan and Burnstock, 2005).
Gene_expression (expressed) of P2X3 in neurons associated with targeted disruption
11) Confidence 0.62 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.66 Pain Relevance 0.03
Thus, our data indicate a major gain of function of P2X3 receptors without their concomitant overexpression at the plasma membrane or a larger number of P2X3 receptor expressing neurons.
Gene_expression (expressing) of P2X3 in neurons
12) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.21 Pain Relevance 0.47
For immunofluorescence microscopy, the following antibodies were used: anti-P2X3, anti-P2X2, anti-TRPV1 and anti-CaV2.1 ?
Gene_expression (anti) of P2X3
13) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.13 Pain Relevance 0
R192Q KI neurons lack constitutive serine phosphorylation of P2X3 receptors
Gene_expression (receptors) of P2X3 in neurons
14) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
For immunofluorescence microscopy, the following antibodies were used: anti-P2X3, anti-P2X2, anti-TRPV1 and anti-CaV2.1 ?
Gene_expression (anti) of P2X3
15) Confidence 0.62 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.13 Pain Relevance 0
We investigated whether neutralizing NGF might change the function of P2X3 receptors natively coexpressed with NGF receptors on cultured mouse trigeminal neurons.
Gene_expression (coexpressed) of P2X3 in neurons
16) Confidence 0.58 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17670966 Disease Relevance 0.60 Pain Relevance 0.65
Finally, in C58 mice there was a shift toward smaller P2X3-expressing neuronal profiles after injury, suggesting that a loss of P2X3 mRNA transcript occurred preferentially in medium-sized cells.
Gene_expression (expressing) of P2X3 in neuronal associated with injury
17) Confidence 0.56 Published 2010 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 20433603 Disease Relevance 1.52 Pain Relevance 0.51
Here we found that high level Ret expression and P2X3 expression were completely eliminated in IB4+ neurons in L-CKO mice (Fig. 1B), whereas their expression in IB4-negative neurons was largely unaffected (Fig. 1B).
Gene_expression (expression) of P2X3 in neurons
18) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.18 Pain Relevance 0.40
In view of the distribution of P2X3 receptor expression [22], we restricted our sampling to neurons that are larger than 15 ?
Gene_expression (expression) of P2X3 in neurons
19) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0.11
We showed that a subpopulation of P2X3 expressing neurons also expressed CaV2.1 channels, thus providing ample opportunity for their crosstalk.
Gene_expression (expressing) of P2X3 in neurons
20) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.19 Pain Relevance 0.44

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