INT91917

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 6.56
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 3
Colon 1
nerve 1
dorsal root ganglion 1
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 32 100.00 Very High Very High Very High
nociceptor 11 100.00 Very High Very High Very High
qutenza 5 100.00 Very High Very High Very High
Root ganglion neuron 3 99.92 Very High Very High Very High
dorsal root ganglion 16 99.50 Very High Very High Very High
agonist 27 99.10 Very High Very High Very High
Lasting pain 4 98.92 Very High Very High Very High
Eae 3 93.80 High High
Central nervous system 4 87.64 High High
antagonist 9 86.24 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 22 99.60 Very High Very High Very High
Pain 32 98.92 Very High Very High Very High
Sprains And Strains 14 98.48 Very High Very High Very High
Injury 8 96.96 Very High Very High Very High
Nociception 3 92.72 High High
Overactive Bladder 9 92.16 High High
Abnormal Reflex 6 90.72 High High
Targeted Disruption 46 90.68 High High
Neuropathic Pain 2 75.00 Quite High
Inflammatory Pain 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies localize P2X3 to nerve fibres innervating the urinary bladder of wild-type mice, and show that loss of P2X3 does not alter sensory neuron innervation density.
Negative_regulation (loss) of P2X3 in nerve
1) Confidence 0.59 Published 2000 Journal Nature Section Abstract Doc Link 11069181 Disease Relevance 0.74 Pain Relevance 0.45
The present study suggests that the downregulation of sensory P2X3 could be one of the molecular predispositions to low sensitivity to tissue injury pain in the A/J inbred mouse strain.
Negative_regulation (downregulation) of P2X3 associated with pain, injury and sprains and strains
2) Confidence 0.57 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12028354 Disease Relevance 1.37 Pain Relevance 0.68
By using subthreshold concentrations of an HAD-potent agonist, it might be possible to generate sustained inhibition of P2X3 receptors for controlling chronic pain.
Negative_regulation (inhibition) of P2X3 associated with lasting pain and agonist
3) Confidence 0.57 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16627751 Disease Relevance 0.10 Pain Relevance 0.40
Here we show that mice deficient in P2X3 lose the rapidly desensitizing ATP-induced currents in dorsal root ganglion neurons.
Negative_regulation (deficient) of P2X3 in dorsal root ganglion associated with ganglion cysts and root ganglion neuron
4) Confidence 0.43 Published 2000 Journal Nature Section Abstract Doc Link 11069181 Disease Relevance 0.65 Pain Relevance 0.33
P2X3 deficiency also causes a reduction in the sustained ATP-induced currents in nodose ganglion neurons.
Negative_regulation (deficiency) of P2X3 in neurons associated with ganglion cysts
5) Confidence 0.43 Published 2000 Journal Nature Section Abstract Doc Link 11069181 Disease Relevance 0.73 Pain Relevance 0.39
Downregulation of P2X3 receptor-dependent sensory functions in A/J inbred mouse strain.
Negative_regulation (Downregulation) of P2X3 associated with qutenza and sprains and strains
6) Confidence 0.42 Published 2002 Journal Eur. J. Neurosci. Section Title Doc Link 12028354 Disease Relevance 1.21 Pain Relevance 1.14
Here we have used antisense oligonucleotides (ASOs) to downregulate P2X3 receptors to examine their role in models of chronic pain in the rat.
Negative_regulation (downregulate) of P2X3 associated with lasting pain
7) Confidence 0.42 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223568 Disease Relevance 0.58 Pain Relevance 0.24
Experimental and modeling studies of desensitization of P2X3 receptors.
Negative_regulation (desensitization) of P2X3
8) Confidence 0.42 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16627751 Disease Relevance 0.10 Pain Relevance 0.28
In the present study, we examined the P2X receptors on DRG and nodose neurons from P2X3-deficient (P2X3-/-) mice, using whole cell voltage-clamp recording and immunohistochemistry.
Negative_regulation (deficient) of P2X3 in neurons associated with dorsal root ganglion
9) Confidence 0.42 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11860473 Disease Relevance 0.51 Pain Relevance 0.26
In OSM-deficient mice, TRPV1/P2X3/OSMRbeta triple-positive neurons were significantly decreased.
Negative_regulation (decreased) of P2X3 in neurons
10) Confidence 0.37 Published 2005 Journal Anat Sci Int Section Abstract Doc Link 15794131 Disease Relevance 0.13 Pain Relevance 0.22
Deletion of P2X2 and P2X3 Receptor Subunits Does Not Alter Motility of the Mouse Colon


Negative_regulation (Deletion) of P2X3 in Colon
11) Confidence 0.34 Published 2010 Journal Frontiers in Neuroscience Section Title Doc Link PMC2858605 Disease Relevance 0.44 Pain Relevance 0.12

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