INT91918

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Context Info
Confidence 0.72
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.16
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 2
nerve 2
DRG 2
colon 1
C8-B4 1
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 32 99.62 Very High Very High Very High
Calcitonin gene-related peptide 9 99.60 Very High Very High Very High
Cancer pain 2 98.08 Very High Very High Very High
Eae 2 97.60 Very High Very High Very High
Neurotransmitter 7 95.40 Very High Very High Very High
Spinal cord 17 91.68 High High
Dorsal horn 21 90.72 High High
Root ganglion neuron 1 83.32 Quite High
Hyperalgesia 1 82.04 Quite High
nociceptor 17 81.16 Quite High
Disease Link Frequency Relevance Heat
Pain 31 98.16 Very High Very High Very High
Cancer Pain 2 98.08 Very High Very High Very High
Nociception 8 97.96 Very High Very High Very High
Overactive Bladder 3 95.96 Very High Very High Very High
Abnormal Reflex 2 94.52 High High
Cancer 5 87.76 High High
Ganglion Cysts 13 87.24 High High
Targeted Disruption 120 86.76 High High
Fibrosarcoma 1 85.44 High High
Hyperalgesia 1 82.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain.
Localization (localization) of P2X3 in nerve associated with pain and cancer pain
1) Confidence 0.72 Published 2005 Journal Brain Res. Section Title Doc Link 15885218 Disease Relevance 0.58 Pain Relevance 0.47
Immunohistochemical studies localize P2X3 to nerve fibres innervating the urinary bladder of wild-type mice, and show that loss of P2X3 does not alter sensory neuron innervation density.
Localization (localize) of P2X3 in nerve
2) Confidence 0.70 Published 2000 Journal Nature Section Abstract Doc Link 11069181 Disease Relevance 0.76 Pain Relevance 0.45
The phosphorylation state of P2X3 receptors is important to control ATP-mediated responses of nociceptive neurons
Localization (receptors) of P2X3 in neurons associated with nociception
3) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.25 Pain Relevance 0.22
CGRP-LI and IB4 were co-localized in 22% of retrogradely labelled cells, whilst P2X3-LI and IB4 were co-localized in 7% (vs 34% seen in the whole DRG population).
Localization (localized) of P2X3 in DRG associated with calcitonin gene-related peptide
4) Confidence 0.68 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 14764211 Disease Relevance 0.27 Pain Relevance 0.52
CGRP-LI and IB4 were co-localized in 22% of retrogradely labelled cells, whilst P2X3-LI and IB4 were co-localized in 7% (vs 34% seen in the whole DRG population).
Localization (localized) of P2X3 in DRG associated with calcitonin gene-related peptide
5) Confidence 0.68 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 14764211 Disease Relevance 0.28 Pain Relevance 0.53
This latter suggestion is consistent with data showing localization of P2X3, P2X5 and P2X7 receptors to the longitudinal muscle of the canine colon (Lee et al., 2005).
Localization (localization) of P2X3 in colon
6) Confidence 0.64 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.16 Pain Relevance 0.06
However, only P2X2, P2X3 and P2X5 subunits have been localized to enteric neurons in the mouse gut (Ruan and Burnstock, 2005).
Localization (localized) of P2X3 in gut
7) Confidence 0.60 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.65 Pain Relevance 0.03
Interestingly, nearly 50% of GFP immunoreactive DRG neurons were immunoreactive for either the TRPV1 receptor or the P2X3 receptor (Figure 1J–O and Figure 2A) but again only a small proportion of TRPV1 receptor immunoreactive (22%) or P2X3 receptor immunoreactive (9%) neurons were immunoreactive for GFP (Figure 2B).


Localization (proportion) of P2X3 in neurons
8) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1479315 Disease Relevance 0.08 Pain Relevance 0.45
We found significant amounts of P2X3, P2X4, P2X6, and P2X7 transcripts in resting C8-B4 cells with the following relative expression levels: P2X7 > P2X4 > P2X3 > P2X6.
Localization (amounts) of P2X3 in C8-B4
9) Confidence 0.31 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.09
This contrasts with the localization of P2X3 receptors in lipid rafts following 1% Triton X treatment in cerebellar granule neurons (14) and suggests that differences in lipid composition or the repertoire of accessory proteins differs between HEK293 cells and granule cells.
Localization (localization) of P2X3 in granule cells
10) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0

General Comments

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