INT91927

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Context Info
Confidence 0.07
First Reported 2000
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.47
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
DRG 1
substantia gelatinosa 1
LOC682801 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 15 100.00 Very High Very High Very High
c fibre 4 99.84 Very High Very High Very High
substantia gelatinosa 3 99.58 Very High Very High Very High
Nav1.6 2 99.52 Very High Very High Very High
dorsal root ganglion 8 99.46 Very High Very High Very High
Nav1.1 2 99.08 Very High Very High Very High
Dorsal horn 5 98.86 Very High Very High Very High
Spinal cord 12 97.96 Very High Very High Very High
diabetic neuropathy 2 97.60 Very High Very High Very High
nav1.3 4 93.44 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 99.46 Very High Very High Very High
Diabetic Neuropathy 2 97.60 Very High Very High Very High
Neuropathic Pain 11 75.00 Quite High
Injury 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study utilised in situ hybridisation to determine the specific expression of adrenoceptors within adult rat lumbar SDH and dorsal root ganglion (DRG) neurons, and reports the presence of alpha1A, alpha1B, alpha2B, beta1 and beta2 adrenoceptor mRNA within SDH neurons, and the presence of alpha1A, alpha1B and alpha2C adrenoceptor mRNA within DRG neurons.
Transcription (presence) of beta1 in DRG associated with ganglion cysts, dorsal root ganglion and dorsal horn
1) Confidence 0.07 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15862909 Disease Relevance 0.37 Pain Relevance 0.70
Moreover, beta1 and beta3 mRNA levels were also unchanged.
Transcription (levels) of beta1
2) Confidence 0.04 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12941467 Disease Relevance 0 Pain Relevance 1.10
In the present study we have used in situ hybridization to examine the changes in mRNA expression of the voltage gated sodium channel subunits beta1 and beta3, which occur in response to streptozocin induced diabetic neuropathy.
Transcription (expression) of beta1 associated with diabetic neuropathy and sodium channel
3) Confidence 0.03 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11489532 Disease Relevance 0.54 Pain Relevance 0.65
In situ hybridization studies demonstrated high levels of beta3 mRNA in small-diameter c-fibres, while beta1 mRNA was virtually absent in these cell types but was expressed in 100% of large-diameter neurons.
Neg (absent) Transcription (absent) of beta1 in neurons associated with c fibre
4) Confidence 0.01 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.15 Pain Relevance 0.46
In situ hybridization studies demonstrated high levels of beta3 mRNA in small-diameter c-fibres, while beta1 mRNA was virtually absent in these cell types but was expressed in 100% of large-diameter neurons.
Neg (absent) Transcription (expressed) of beta1 in neurons associated with c fibre
5) Confidence 0.01 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.15 Pain Relevance 0.47
In the spinal cord, beta3 transcript was present specifically in layers I/II (substantia gelatinosa) and layer X, while beta1 mRNA was expressed in all laminae throughout the grey matter.
Transcription (expressed) of beta1 in substantia gelatinosa associated with substantia gelatinosa and spinal cord
6) Confidence 0.01 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.27 Pain Relevance 0.55

General Comments

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