INT91928

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Context Info
Confidence 0.06
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcnab3) cytoplasm (Kcnab3)
Anatomy Link Frequency
DRG 2
hippocampus 2
Kcnab3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 7 100.00 Very High Very High Very High
Lamotrigine 23 99.52 Very High Very High Very High
Hippocampus 4 99.06 Very High Very High Very High
Neuropathic pain 3 98.68 Very High Very High Very High
Eae 2 97.64 Very High Very High Very High
Central nervous system 5 95.28 Very High Very High Very High
sodium channel 4 90.80 High High
antagonist 1 87.36 High High
Glutamate receptor 3 85.92 High High
Calcium channel 2 85.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 3 98.68 Very High Very High Very High
Injury 2 97.64 Very High Very High Very High
Neuroblastoma 3 94.32 High High
Epilepsy 1 77.52 Quite High
Manic Depressive Disorder 125 74.72 Quite High
Urological Neuroanatomy 1 66.36 Quite High
Death 1 61.20 Quite High
Apoptosis 4 60.96 Quite High
Lymphatic System Cancer 1 57.76 Quite High
Cv Unclassified Under Development 1 39.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A gene expression study performed on primary cultured rat hippocampus cells treated with LTG 0.1 mM showed that the expression of the GABA-A receptor beta3 subunit was increased by the treatment [133].
Positive_regulation (increased) of Gene_expression (expression) of beta3 in hippocampus associated with gaba, lamotrigine and hippocampus
1) Confidence 0.06 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.55 Pain Relevance 1.06
Results revealed a significant increase in beta3 mRNA expression in small-diameter sensory neurons of the ipsilateral DRG.
Positive_regulation (increase) of Gene_expression (expression) of beta3 in DRG
2) Confidence 0.03 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.35 Pain Relevance 0.63

General Comments

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