INT91929

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Context Info
Confidence 0.31
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.15
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Nr5a2) nucleus (Nr5a2) DNA binding (Nr5a2)
cytoplasm (Nr5a2)
Anatomy Link Frequency
spinal nerve 1
neurons 1
motoneurons 1
Nr5a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 13 99.04 Very High Very High Very High
gABA 14 99.00 Very High Very High Very High
Spinal cord 10 98.24 Very High Very High Very High
Peripheral nerve injury 4 98.24 Very High Very High Very High
Calcitonin gene-related peptide 9 94.96 High High
sodium channel 4 94.12 High High
Dorsal horn 4 93.76 High High
Spinal nerve ligature 6 90.96 High High
tetrodotoxin 3 88.20 High High
Action potential 1 87.56 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 13 99.04 Very High Very High Very High
Nervous System Injury 6 98.24 Very High Very High Very High
Facial Paralysis 1 94.64 High High
Nociception 4 90.16 High High
Injury 3 75.00 Quite High
Neuropathic Pain 3 75.00 Quite High
Pain 2 55.36 Quite High
Headache 2 55.16 Quite High
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data demonstrate that axotomy strongly reduced the amounts of alpha1, beta2, and gamma2 subunits of GABA(A) receptors and B(1B) and B(2) subunits of GABA(B) receptors in the axotomized facial motoneurons.
Gene_expression (amounts) of beta2 in motoneurons associated with gaba
1) Confidence 0.31 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15857688 Disease Relevance 0.09 Pain Relevance 0.71
The BK(Ca) channel protein and the modulatory beta2- and beta4-subunt proteins were more expressed in the TNC than in the TG.
Gene_expression (expressed) of beta2 associated with trigeminal ganglion
2) Confidence 0.14 Published 2010 Journal Neuroscience Section Abstract Doc Link 20211697 Disease Relevance 1.10 Pain Relevance 0.96
The expression of the alpha4, alpha7, beta2, beta3 and beta4 subunits was unchanged.
Gene_expression (expression) of beta2
3) Confidence 0.09 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 14741388 Disease Relevance 0.37 Pain Relevance 0.55
We examined the expression of the alpha3, alpha4, alpha5, alpha7, beta2, beta3 and beta4 nicotinic subunits in the spinal cord of normal and spinal nerve ligated rats using immunocytochemistry.
Spec (examined) Gene_expression (expression) of beta2 in spinal nerve associated with spinal cord
4) Confidence 0.09 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 14741388 Disease Relevance 0.43 Pain Relevance 0.52
However, of the auxiliary subunits, beta1 is expressed preferentially in only large- and medium-diameter neurons of the DRG while beta2 is absent in all DRG cells.
Neg (absent) Gene_expression (absent) of beta2 in neurons
5) Confidence 0.03 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.15 Pain Relevance 0.39
Single-cell RT-PCR experiments identified alpha4, alpha7, and beta2 as the predominantly expressed mRNAs, suggesting that the receptors consisted of alpha7 homomers and alpha4beta2 heteromers.
Gene_expression (expressed) of beta2
6) Confidence 0.02 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12205153 Disease Relevance 0 Pain Relevance 0.39

General Comments

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