INT91930

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Context Info
Confidence 0.16
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 4.41
Pain Relevance 7.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcnab3) cytoplasm (Kcnab3)
Anatomy Link Frequency
spinal nerve 1
sensory neurons 1
spinal cord 1
oocytes 1
hippocampus 1
Kcnab3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 20 100.00 Very High Very High Very High
gABA 9 100.00 Very High Very High Very High
antagonist 8 100.00 Very High Very High Very High
Pain 8 100.00 Very High Very High Very High
substantia gelatinosa 4 100.00 Very High Very High Very High
Spinal cord 24 99.96 Very High Very High Very High
Abeta 2 99.70 Very High Very High Very High
dorsal root ganglion 10 99.56 Very High Very High Very High
Lamotrigine 23 99.52 Very High Very High Very High
Neuropeptide 3 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 10 99.56 Very High Very High Very High
Neuropathic Pain 16 98.78 Very High Very High Very High
Nervous System Injury 6 98.24 Very High Very High Very High
Injury 8 97.16 Very High Very High Very High
Deafness 4 96.36 Very High Very High Very High
Diabetic Neuropathy 4 94.48 High High
Neuroblastoma 3 92.56 High High
Headache 4 92.24 High High
Nociception 4 90.16 High High
Epilepsy 1 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the expression of the alpha3, alpha4, alpha5, alpha7, beta2, beta3 and beta4 nicotinic subunits in the spinal cord of normal and spinal nerve ligated rats using immunocytochemistry.
Spec (examined) Gene_expression (expression) of beta3 in spinal nerve associated with spinal cord
1) Confidence 0.16 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 14741388 Disease Relevance 0.43 Pain Relevance 0.52
The expression of the alpha4, alpha7, beta2, beta3 and beta4 subunits was unchanged.
Gene_expression (expression) of beta3
2) Confidence 0.16 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 14741388 Disease Relevance 0.37 Pain Relevance 0.55
In conclusion, the present study illustrates that the development of the neuropathic pain state is associated with distinct changes in the pattern of beta3 subunit expression and that these changes appear to be specific to the neuropathic pain state induced.
Gene_expression (expression) of beta3 associated with neuropathic pain
3) Confidence 0.15 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11489532 Disease Relevance 0.77 Pain Relevance 0.90
SR 59230A (beta3 antagonist) also produced no significant inhibition (SSS, P = 0.7; L-glutamate, P = 0.2), indicating an inhibitory role for beta1 antagonists only. beta Blockers therefore may exert some of their therapeutic effects in migraine through beta1 adrenoceptor antagonist actions in the thalamus.
Gene_expression (produced) of beta3 in thalamus associated with glutamate, migraine, antagonist and thalamus
4) Confidence 0.13 Published 2005 Journal Brain Section Abstract Doc Link 15574468 Disease Relevance 0.17 Pain Relevance 1.08
Under control conditions beta1 mRNA was detected throughout the spinal cord and in large dorsal root ganglion (DRG) Abeta fibres whilst beta3 mRNA was expressed exclusively in the layers I/II and X of the spinal cord and in small DRG c-fibres.
Gene_expression (expressed) of beta3 in spinal cord associated with ganglion cysts, c fibre, dorsal root ganglion, abeta and spinal cord
5) Confidence 0.11 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11489532 Disease Relevance 0.69 Pain Relevance 0.89
Expression of genes for GABA-A receptor subunits beta2, beta3, and gamma2, plus ionotropic glutamate receptor subunits AMPA 2, AMPA 3, and kainate 2, increased at all three times.
Gene_expression (Expression) of beta3 associated with gaba and glutamate receptor
6) Confidence 0.11 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15934929 Disease Relevance 0.35 Pain Relevance 0.38
A gene expression study performed on primary cultured rat hippocampus cells treated with LTG 0.1 mM showed that the expression of the GABA-A receptor beta3 subunit was increased by the treatment [133].
Gene_expression (expression) of beta3 in hippocampus associated with gaba, lamotrigine and hippocampus
7) Confidence 0.06 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.54 Pain Relevance 1.05
Since the pattern of beta3 expression in DRG appears to correlate with the TTX-resistant voltage-gated sodium channel subunit PN3, we co-expressed the two subunits in Xenopus oocytes.
Gene_expression (expression) of beta3 in oocytes associated with sodium channel
8) Confidence 0.05 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.28 Pain Relevance 0.55
beta3, a novel auxiliary subunit for the voltage-gated sodium channel, is expressed preferentially in sensory neurons and is upregulated in the chronic constriction injury model of neuropathic pain.
Gene_expression (expressed) of beta3 in sensory neurons associated with pain, eae, injury, neuropathic pain and sodium channel
9) Confidence 0.05 Published 2000 Journal Eur. J. Neurosci. Section Title Doc Link 11069594 Disease Relevance 0.19 Pain Relevance 0.65
Results revealed a significant increase in beta3 mRNA expression in small-diameter sensory neurons of the ipsilateral DRG.
Gene_expression (expression) of beta3 in DRG
10) Confidence 0.04 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.35 Pain Relevance 0.63
In the spinal cord, beta3 transcript was present specifically in layers I/II (substantia gelatinosa) and layer X, while beta1 mRNA was expressed in all laminae throughout the grey matter.
Gene_expression (expressed) of beta3 in substantia gelatinosa associated with substantia gelatinosa and spinal cord
11) Confidence 0.04 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.27 Pain Relevance 0.56

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