INT91931

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Context Info
Confidence 0.13
First Reported 2000
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.14
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Kcnab3) cytoplasm (Kcnab3)
Anatomy Link Frequency
sensory neurons 1
spinal cord 1
neurons 1
DRG 1
Kcnab3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 16 100.00 Very High Very High Very High
neuralgia 6 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
dorsal root ganglion 10 99.84 Very High Very High Very High
Spinal cord 14 99.68 Very High Very High Very High
Eae 6 99.68 Very High Very High Very High
Neuropathic pain 13 99.40 Very High Very High Very High
c fibre 5 99.04 Very High Very High Very High
Adelta 2 98.08 Very High Very High Very High
diabetic neuropathy 4 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 10 99.84 Very High Very High Very High
Neuropathic Pain 13 99.40 Very High Very High Very High
Injury 6 98.84 Very High Very High Very High
Diabetic Neuropathy 4 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Beta3, a novel auxiliary subunit for the voltage gated sodium channel is upregulated in sensory neurones following streptozocin induced diabetic neuropathy in rat.
Positive_regulation (upregulated) of Beta3 associated with neuralgia, diabetic neuropathy and sodium channel
1) Confidence 0.13 Published 2001 Journal Neurosci. Lett. Section Title Doc Link 11489532 Disease Relevance 0.64 Pain Relevance 1.12
Following streptozocin treatment, the expression of beta1 mRNA remained unchanged in both the spinal cord and DRG whilst beta3 message was significantly increased in both the spinal cord and in medium diameter Adelta type DRG neurones.
Positive_regulation (increased) of beta3 in spinal cord associated with dorsal root ganglion, adelta and spinal cord
2) Confidence 0.08 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11489532 Disease Relevance 0.72 Pain Relevance 0.94
These results show that beta3 is the dominant auxiliary sodium channel subunit in small-diameter neurons of the rat DRG and that it is significantly upregulated in a model of neuropathic pain.
Positive_regulation (upregulated) of beta3 in DRG associated with neuropathic pain and sodium channel
3) Confidence 0.04 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.44 Pain Relevance 0.64
beta3, a novel auxiliary subunit for the voltage-gated sodium channel, is expressed preferentially in sensory neurons and is upregulated in the chronic constriction injury model of neuropathic pain.
Positive_regulation (upregulated) of beta3 in sensory neurons associated with pain, eae, injury, neuropathic pain and sodium channel
4) Confidence 0.04 Published 2000 Journal Eur. J. Neurosci. Section Title Doc Link 11069594 Disease Relevance 0.20 Pain Relevance 0.66
In situ hybridization studies demonstrated high levels of beta3 mRNA in small-diameter c-fibres, while beta1 mRNA was virtually absent in these cell types but was expressed in 100% of large-diameter neurons.
Positive_regulation (levels) of beta3 in neurons associated with c fibre
5) Confidence 0.03 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11069594 Disease Relevance 0.15 Pain Relevance 0.46

General Comments

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