INT91946

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.13
Pain Relevance 5.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkce) Golgi apparatus (Prkce) endoplasmic reticulum (Prkce)
enzyme binding (Prkce) cytoplasm (Prkce) cytosol (Prkce)
Anatomy Link Frequency
nociceptors 2
Prkce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 10 100.00 Very High Very High Very High
addiction 2 100.00 Very High Very High Very High
Hyperalgesia 21 99.68 Very High Very High Very High
Pain 8 99.48 Very High Very High Very High
Inflammation 6 99.48 Very High Very High Very High
IPN 3 99.08 Very High Very High Very High
nociceptor 9 98.76 Very High Very High Very High
Neuropathic pain 7 98.72 Very High Very High Very High
dorsal root ganglion 6 97.60 Very High Very High Very High
tetrodotoxin 1 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 23 99.68 Very High Very High Very High
Inflammatory Pain 3 99.08 Very High Very High Very High
Neuropathic Pain 9 98.72 Very High Very High Very High
Ganglion Cysts 6 97.60 Very High Very High Very High
Nociception 5 97.36 Very High Very High Very High
INFLAMMATION 3 88.00 High High
Targeted Disruption 1 82.36 Quite High
Shock 1 76.44 Quite High
Alcoholic Neuropathy 2 75.00 Quite High
Peripheral Neuropathy 2 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western immunoblot analysis indicated a higher level of PKCepsilon in dorsal root ganglia from alcohol-fed rats, supporting a role for enhanced PKCepsilon second-messenger signaling in nociceptors contributing to alcohol-induced hyperalgesia.
Regulation (role) of PKCepsilon in nociceptors associated with hyperalgesia, nociceptor and alcohol
1) Confidence 0.44 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11069970 Disease Relevance 0.72 Pain Relevance 1.24
Western immunoblot analysis indicated a higher level of PKCepsilon in dorsal root ganglia from alcohol-fed rats, supporting a role for enhanced PKCepsilon second-messenger signaling in nociceptors contributing to alcohol-induced hyperalgesia.
Regulation (role) of PKCepsilon in nociceptors associated with hyperalgesia, nociceptor and alcohol
2) Confidence 0.44 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11069970 Disease Relevance 0.74 Pain Relevance 1.27
Estrogen has a dual effect on PKCepsilon.
Regulation (effect) of PKCepsilon
3) Confidence 0.25 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16836642 Disease Relevance 0.65 Pain Relevance 0.48
Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat.
Regulation (contribution) of PKCepsilon associated with inflammation and ipn
4) Confidence 0.16 Published 2001 Journal Eur. J. Neurosci. Section Title Doc Link 11454025 Disease Relevance 0.71 Pain Relevance 1.07
When PGE(2) hyperalgesia was shifted to dependence on PKCepsilon and ERK as well as PKA, as when the tissue is "primed" by prior treatment with carrageenan, it too became dependent on an intact cytoskeleton.
Regulation (dependence) of PKCepsilon associated with addiction and hyperalgesia
5) Confidence 0.07 Published 2003 Journal Neuron Section Abstract Doc Link 12925276 Disease Relevance 0.60 Pain Relevance 0.85
CCD is associated with the up-regulation of annexin A2 and PKCepsilon and their related genes.
Regulation (regulation) of PKCepsilon
6) Confidence 0.04 Published 2008 Journal Exp Brain Res Section Abstract Doc Link 18493752 Disease Relevance 0.71 Pain Relevance 0.55

General Comments

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