INT91948

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Context Info
Confidence 0.64
First Reported 2000
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 11.36
Pain Relevance 10.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkce) Golgi apparatus (Prkce) endoplasmic reticulum (Prkce)
enzyme binding (Prkce) cytoplasm (Prkce) cytosol (Prkce)
Anatomy Link Frequency
neurons 3
nociceptors 3
dorsal root ganglia 2
skin 1
Prkce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 19 99.96 Very High Very High Very High
Inflammation 34 99.64 Very High Very High Very High
Hyperalgesia 40 99.50 Very High Very High Very High
alcohol 5 99.34 Very High Very High Very High
agonist 11 99.04 Very High Very High Very High
nociceptor 32 98.76 Very High Very High Very High
Neuropathic pain 8 98.72 Very High Very High Very High
Eae 6 98.48 Very High Very High Very High
Somatostatin 13 98.44 Very High Very High Very High
dorsal root ganglion 22 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 32 99.64 Very High Very High Very High
Hyperalgesia 55 99.50 Very High Very High Very High
Neuropathic Pain 9 98.72 Very High Very High Very High
Injury 7 98.48 Very High Very High Very High
Ganglion Cysts 24 98.32 Very High Very High Very High
Herpes Simplex Virus 1 97.82 Very High Very High Very High
Pain 5 96.20 Very High Very High Very High
Nociception 18 94.20 High High
Inflammatory Pain 4 86.72 High High
Cv Unclassified Under Development 6 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If applied before beta(2)-AR or Epac stimulation, estrogen abrogates the activation of PKCepsilon.
Positive_regulation (activation) of PKCepsilon
1) Confidence 0.64 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16836642 Disease Relevance 0.66 Pain Relevance 0.48
Furthermore, hyperalgesic priming could be induced by an agonist of PKCepsilon (pseudo-receptor octapeptide for activated PKCepsilon) at a dose that itself causes no hyperalgesia.
Positive_regulation (activated) of PKCepsilon associated with hyperalgesia and agonist
2) Confidence 0.56 Published 2003 Journal Neuroscience Section Abstract Doc Link 12849754 Disease Relevance 0.94 Pain Relevance 0.68
Western immunoblot analysis indicated a higher level of PKCepsilon in dorsal root ganglia from alcohol-fed rats, supporting a role for enhanced PKCepsilon second-messenger signaling in nociceptors contributing to alcohol-induced hyperalgesia.
Positive_regulation (enhanced) of PKCepsilon in nociceptors associated with hyperalgesia, nociceptor and alcohol
3) Confidence 0.49 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11069970 Disease Relevance 0.72 Pain Relevance 1.24
Stimulation of beta(2)-adrenergic receptors (beta(2)-AR) leads to PKCepsilon activation in cultured dorsal root ganglia (DRG) neurons derived from male but not from female rats.
Positive_regulation (activation) of PKCepsilon in dorsal root ganglia
4) Confidence 0.46 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16836642 Disease Relevance 0.57 Pain Relevance 0.44
Addition of estrogen to male DRG neurons produces a switch to the female phenotype, namely abrogation of beta(2)-AR-initiated activation of PKCepsilon.
Positive_regulation (activation) of PKCepsilon in neurons
5) Confidence 0.46 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16836642 Disease Relevance 0.58 Pain Relevance 0.45
Furthermore, the PGE2-induced hyperalgesia in primed skin was found to require activity of the epsilon isozyme of protein kinase C (PKCepsilon), a second messenger that is not required for PGE2-induced hyperalgesia in control animals.
Neg (not) Positive_regulation (required) of PKCepsilon in skin associated with kinase c and hyperalgesia
6) Confidence 0.40 Published 2003 Journal Neuroscience Section Abstract Doc Link 12849754 Disease Relevance 1.00 Pain Relevance 0.64
This regulation of priming by estrogen appears to occur at or downstream of the activation of PKC epsilon.
Positive_regulation (activation) of PKC epsilon
7) Confidence 0.40 Published 2003 Journal Pain Section Abstract Doc Link 14499430 Disease Relevance 0.87 Pain Relevance 0.32
Infusion of a GJ blocker, heptanol, before reperfusion reduced infarct size by 36%, and this protection was not enhanced by preischemic infusion of rottlerin + DADLE, which allows PKC-epsilon activation by DADLE.
Positive_regulation (activation) of PKC-epsilon
8) Confidence 0.38 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17513490 Disease Relevance 0.37 Pain Relevance 0.50
Specific agonists for the classical estrogen receptors (ER), ERalpha and ERbeta, did not result in activation of PKCepsilon in neurons of dissociated rat dorsal root ganglia.
Positive_regulation (activation) of PKCepsilon in dorsal root ganglia associated with agonist
9) Confidence 0.19 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18371086 Disease Relevance 0.23 Pain Relevance 0.41
These data indicate that functional activation of PKCepsilon has a close relationship with the production of inflammatory hyperalgesia and the sensitization of the nociceptors.
Positive_regulation (activation) of PKCepsilon in nociceptors associated with hyperalgesia, inflammation and nociceptor
10) Confidence 0.18 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694383 Disease Relevance 1.39 Pain Relevance 0.95
Using phosphospecific antibody against the C-terminal hydrophobic site Ser729 of PKCepsilon as a marker of enzyme activation, the state-dependent activation of PKCepsilon, as well as the expression of VR1 in rat DRG neurons, was evaluated in different experimental pain models in vivo.
Positive_regulation (activation) of PKCepsilon in neurons associated with pain and dorsal root ganglion
11) Confidence 0.18 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694383 Disease Relevance 0.97 Pain Relevance 0.53
Here, we employ a highly defective herpes simplex virus vector (vHDNP) that expresses dominant negative PKCepsilon (DNPKCepsilon) as a strategy to demonstrate that PKCepsilon is essential for: (i) maintenance of basal phosphorylation and normal TRPV1 responses to capsaicin (CAPS), a TRPV1 agonist and (ii) enhancement of TRPV1 responses by phorbol esters.
Positive_regulation (essential) of PKCepsilon associated with qutenza, herpes simplex virus and agonist
12) Confidence 0.12 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973552 Disease Relevance 0.41 Pain Relevance 0.85
Inflammatory mediator-induced activation of PKCepsilon and subsequent sensitization of VR1 to noxious stimuli by PKCepsilon may be involved in nociceptor sensitization.
Positive_regulation (activation) of PKCepsilon in nociceptor associated with inflammation and nociceptor
13) Confidence 0.12 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694383 Disease Relevance 1.31 Pain Relevance 0.91
These results indicate that the prolonged activation of somatostatin receptors induces the desensitization of somatostatin-induced inhibition on low [Mg(2+)](o)-induced [Ca(2+)](i) spikes through the activation of GRK2 and partly a novel PKCepsilon in cultured rat hippocampal neurons.
Positive_regulation (activation) of PKCepsilon in neurons associated with somatostatin
14) Confidence 0.05 Published 2006 Journal Brain Res. Section Abstract Doc Link 16879804 Disease Relevance 0.05 Pain Relevance 0.52
CCD is associated with the up-regulation of annexin A2 and PKCepsilon and their related genes.
Positive_regulation (regulation) of PKCepsilon
15) Confidence 0.04 Published 2008 Journal Exp Brain Res Section Abstract Doc Link 18493752 Disease Relevance 0.71 Pain Relevance 0.55
Conversely, hyperalgesia produced by agents that activate PKA or PKCepsilon was unaffected by MEK inhibitors.
Positive_regulation (activate) of PKCepsilon associated with hyperalgesia
16) Confidence 0.03 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11517280 Disease Relevance 0.59 Pain Relevance 0.85

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