INT9196

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Context Info
Confidence 0.77
First Reported 1984
Last Reported 2011
Negated 7
Speculated 3
Reported most in Abstract
Documents 215
Total Number 218
Disease Relevance 96.99
Pain Relevance 60.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
body 7
colon 5
PGE2 4
platelet 3
stomach 3
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 279 100.00 Very High Very High Very High
COX2 135 100.00 Very High Very High Very High
cOX1 93 100.00 Very High Very High Very High
Spinal cord 7 100.00 Very High Very High Very High
Serotonin 5 100.00 Very High Very High Very High
cINOD 962 99.98 Very High Very High Very High
Inflammatory mediators 41 99.96 Very High Very High Very High
cytokine 264 99.92 Very High Very High Very High
Paracetamol 66 99.86 Very High Very High Very High
Perioperative pain 11 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 858 100.00 Very High Very High Very High
Colon Cancer 328 100.00 Very High Very High Very High
Necrosis 30 100.00 Very High Very High Very High
Adhesions 21 100.00 Very High Very High Very High
INFLAMMATION 1225 99.96 Very High Very High Very High
Breast Cancer 394 99.88 Very High Very High Very High
Stomach Cancer 58 99.88 Very High Very High Very High
Post Operative Pain 8 99.84 Very High Very High Very High
Glioma 7 99.84 Very High Very High Very High
Pain 99 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase-1 is primarily involved in the maintenance of organ function whereas cyclooxygenase-2 is expressed in inflamed tissue.
Gene_expression (expressed) of cyclooxygenase
1) Confidence 0.77 Published 1997 Journal Med. Klin. (Munich) Section Abstract Doc Link 9483916 Disease Relevance 0.38 Pain Relevance 0.38
The synthesis of cyclooxygenase (CO) and lipoxygenase (LO) metabolites of arachidonic acids, such as prostaglandins (PG) E2, F2 alpha, 6-keto-P1 alpha, thromboxane B2 (TB2), leukotriene B4 (LTB4) and hydroxyeicosatetraenic acids (HETEA) in the biopsy specimens of the colonic mucosa (CM) was studied in vitro in 30 patients aged 17-66 years who had ulcerative colitis (UC) of various severity and extent.
Gene_expression (synthesis) of cyclooxygenase associated with inflammatory bowel disease
2) Confidence 0.75 Published 2003 Journal Klin Med (Mosk) Section Abstract Doc Link 14664173 Disease Relevance 0.43 Pain Relevance 0.07
We have sought to answer the question whether human cyclooxygenase-1b, if expressed, is a target of acetaminophen.
Gene_expression (expressed) of cyclooxygenase associated with paracetamol
3) Confidence 0.75 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17045584 Disease Relevance 0 Pain Relevance 0.42
Human prostaglandin G/H synthase (hPGHS)-1 and hPGHS-2, key enzymes in the formation of prostanoids from arachidonic acid, were expressed at high levels in COS-7 cells using a T7 RNA polymerase/vaccinia virus expression system.
Gene_expression (expressed) of prostaglandin G/H synthase associated with pox virus infection
4) Confidence 0.75 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 8114674 Disease Relevance 0.40 Pain Relevance 0.07
We discuss CNS cells types, including neurons, glia, and cerebrovascular elements, where cyclooxygenases-1 and -2 are expressed under normal conditions or can be induced by physiological or pathological stimuli.
Gene_expression (expressed) of cyclooxygenase in neurons associated with central nervous system
5) Confidence 0.75 Published 2000 Journal Curr. Pharm. Des. Section Abstract Doc Link 11203433 Disease Relevance 0.58 Pain Relevance 0.55
Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs.
Gene_expression (expression) of cyclooxygenase associated with inflammation, cinod and cox1
6) Confidence 0.75 Published 2004 Journal Am. J. Vet. Res. Section Title Doc Link 15198222 Disease Relevance 0.10 Pain Relevance 0.37
In intact Chinese hamster ovary (CHO) cell lines stably expressing the hPGHS isozymes, both PGHS isoforms exhibited the same affinity for arachidonic acid.
Gene_expression (expressing) of PGHS in CHO
7) Confidence 0.75 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8831731 Disease Relevance 0.17 Pain Relevance 0.35
Cyclooxygenase-2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in pre-neoplastic tissues and several human cancers including colorectal cancer.
Gene_expression (overexpressed) of prostaglandin G/H synthase associated with cancer and colon cancer
8) Confidence 0.75 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353307 Disease Relevance 0.48 Pain Relevance 0.09
Overexpression of human PGHS-1 and PGHS-2 in the human colon carcinoma cells increased the DNA synthesis rate as compared with mock-transfected cells which did not express any isoforms.
Gene_expression (Overexpression) of PGHS-1 in colon associated with colon cancer
9) Confidence 0.74 Published 2009 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 19457650 Disease Relevance 0.33 Pain Relevance 0.25
In contrast, PTGS1 is constitutively expressed and its implication in CRC risk has not been investigated very much, since its carcinogenetic role through induction of PTGS2 has been suggested only recently [16,34].
Gene_expression (expressed) of PTGS1 associated with colon cancer
10) Confidence 0.72 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.73 Pain Relevance 0.09
The human osteosarcoma 143.98.2 cell line was found to express high levels of prostaglandin synthase-2 (PGHS-2) without detectable levels of prostaglandin synthase-1 (PGHS-1) as measured by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunoblot analysis.
Neg (without) Gene_expression (express) of PGHS-1 associated with osteogenic sarcomas
11) Confidence 0.72 Published 1997 Journal Inflamm. Res. Section Abstract Doc Link 9085144 Disease Relevance 0.31 Pain Relevance 0.12
The human osteosarcoma 143.98.2 cell line was found to express high levels of prostaglandin synthase-2 (PGHS-2) without detectable levels of prostaglandin synthase-1 (PGHS-1) as measured by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunoblot analysis.
Neg (without) Gene_expression (express) of prostaglandin synthase-1 associated with osteogenic sarcomas
12) Confidence 0.72 Published 1997 Journal Inflamm. Res. Section Abstract Doc Link 9085144 Disease Relevance 0.31 Pain Relevance 0.12
In contrast, undifferentiated U937 cells selectively express PGHS-1 as analyzed by RT-PCR and Western blotting.
Spec (analyzed) Gene_expression (express) of PGHS-1
13) Confidence 0.72 Published 1997 Journal Inflamm. Res. Section Abstract Doc Link 9085144 Disease Relevance 0.41 Pain Relevance 0.31
Expression of recombinant human cyclooxygenase isoenzymes in transfected COS-7 cells in vitro and inhibition by tenoxicam, indomethacin and aspirin.
Gene_expression (Expression) of cyclooxygenase associated with aspirin
14) Confidence 0.70 Published 1997 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 9175172 Disease Relevance 0.09 Pain Relevance 0.45
These observations indicate that cyclooxygenase inhibition attenuates MSNA responses seen during PEMI and suggest that cyclooxygenase products sensitize the muscle mechanoreceptors.
Gene_expression (products) of cyclooxygenase in muscle associated with ischemia
15) Confidence 0.67 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18441194 Disease Relevance 0.23 Pain Relevance 0.43
Human and animal studies suggest that cyclooxygenase products sensitize muscle mechanoreceptors.
Gene_expression (products) of cyclooxygenase in mechanoreceptors
16) Confidence 0.67 Published 2008 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 18441194 Disease Relevance 0.34 Pain Relevance 0.29
Prostaglandins are bioactive lipids produced from arachidonic acid by cyclooxygenase enzymes and specific terminal prostanoid synthase enzymes.
Gene_expression (produced) of cyclooxygenase
17) Confidence 0.67 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16701939 Disease Relevance 0.21 Pain Relevance 0.08
By immunohistochemical staining, we found that PGHS-1 is the main isoform present in the dermal papilla from normal human hair follicle (either anagen or catagen), whereas PGHS-2 was only faintly and exclusively expressed in anagen dermal papilla.
Gene_expression (expressed) of PGHS-1 in hair follicle
18) Confidence 0.67 Published 1997 Journal J. Invest. Dermatol. Section Abstract Doc Link 9008235 Disease Relevance 0.43 Pain Relevance 0.36
Within the nuclear envelope, PGHS-1 and -2 were present on both the inner and outer nuclear membranes and in similar proportions.
Gene_expression (present) of PGHS-1
19) Confidence 0.66 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9545330 Disease Relevance 0.06 Pain Relevance 0.09
Taken together our data demonstrate that SC-560 acts at least in some cell types as an unselective COX inhibitor despite its selectivity toward COX-1 under cell-free conditions.
Gene_expression (selectivity) of COX-1
20) Confidence 0.65 Published 2006 Journal FASEB J. Section Abstract Doc Link 16816110 Disease Relevance 0 Pain Relevance 0.14

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