INT9197

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 44
Total Number 46
Disease Relevance 18.48
Pain Relevance 16.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
platelet 2
blood 2
neutrophil 2
cartilage 1
cleavage 1
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 20 100.00 Very High Very High Very High
cOX1 15 100.00 Very High Very High Very High
Paracetamol 14 100.00 Very High Very High Very High
COX2 13 100.00 Very High Very High Very High
Osteoarthritis 3 100.00 Very High Very High Very High
intrathecal 2 100.00 Very High Very High Very High
cINOD 137 99.98 Very High Very High Very High
Sciatic nerve 1 99.98 Very High Very High Very High
Analgesic 17 99.96 Very High Very High Very High
aspirin 62 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 20 100.00 Very High Very High Very High
Toxicity 9 100.00 Very High Very High Very High
Asthma 4 100.00 Very High Very High Very High
Osteoarthritis 3 100.00 Very High Very High Very High
INFLAMMATION 100 99.76 Very High Very High Very High
Pain 10 99.60 Very High Very High Very High
Coagulation Disorder 3 99.40 Very High Very High Very High
Colorectal Cancer 7 99.24 Very High Very High Very High
Colon Cancer 16 99.04 Very High Very High Very High
Disease 63 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3.Interactions of prostaglandin-endoperoxide synthase 1 (PTGS1).
PTGS1 Binding (3.Interactions) of
1) Confidence 0.48 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808890 Disease Relevance 0.09 Pain Relevance 0.19
Figure 3.Interactions of prostaglandin-endoperoxide synthase 1 (PTGS1).
prostaglandin-endoperoxide synthase 1 Binding (3.Interactions) of
2) Confidence 0.48 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808890 Disease Relevance 0.09 Pain Relevance 0.18
The results establish that the MBDs of oPGHS-1 and hPGHS-2 reside within residues 74-140 and 59-111, respectively, and thus provide direct provide biochemical support for the hypothesis that PGHS-1 and -2 do associate with membranes through a monotopic MBD.
PGHS-1 Binding (associate) of
3) Confidence 0.47 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10551860 Disease Relevance 0.06 Pain Relevance 0.06
Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
prostaglandin H2 synthase Binding (binding) of associated with cinod and cox1
4) Confidence 0.47 Published 2001 Journal Biochemistry Section Title Doc Link 11318639 Disease Relevance 0.10 Pain Relevance 0.34
Based on these known interactions, some compounds are suggested to interact with PTGS1/2: ethenzamide (D01466), actarit (D01395), N-acetylphenylethylamine (C06746) and N-ethylphenylacetamide (C11487).
PTGS1 Binding (interact) of
5) Confidence 0.46 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2881361 Disease Relevance 0.07 Pain Relevance 0.30
Aspirin has been shown to bind to the PTGS1 gene product (prostaglandin-endoperoxide synthase 1), blocking that enzyme’s ability to produce PGH2 and thereby reducing pain and inflammation.
prostaglandin-endoperoxide synthase 1 Binding (bind) of associated with pain, aspirin and inflammation
6) Confidence 0.41 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808896 Disease Relevance 0.53 Pain Relevance 0.38
Aspirin has been shown to bind to the PTGS1 gene product (prostaglandin-endoperoxide synthase 1), blocking that enzyme’s ability to produce PGH2 and thereby reducing pain and inflammation.
PTGS1 Binding (bind) of associated with pain, aspirin and inflammation
7) Confidence 0.41 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808896 Disease Relevance 0.53 Pain Relevance 0.38
On the other hand, PTGS1 has some other interacting analgesic and antipyretic drugs, such as mofezolac (D01718) (Goto et al., 1998), from which tangeretin (C10190) (Hirano et al., 1995) is suggested as another potential drug.
PTGS1 Binding (interacting) of associated with analgesic
8) Confidence 0.36 Published 2010 Journal Bioinformatics Section Body Doc Link PMC2881361 Disease Relevance 0.07 Pain Relevance 0.25
Defective platelet prostaglandin H synthase (PGHS) activity has been recognized as a cause of bleeding disorders, but the defect has not been characterized.
PGHS Binding (recognized) of in platelet associated with coagulation disorder
9) Confidence 0.34 Published 1996 Journal Br. J. Haematol. Section Abstract Doc Link 8562397 Disease Relevance 0.42 Pain Relevance 0.15
Indomethacin was estimated to form the EI complex with the same affinity for both PGHS1 and PGHS2, 10.0 +/- 2.8 microM and 11.2 +/- 2.0 microM, respectively, and dissociate from EI* at approximately the same rate 0.0011 +/- 0.0002 s-1 and 0.0031 +/- 0.0003 s-1, respectively.
PGHS1 Binding (affinity) of
10) Confidence 0.32 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631960 Disease Relevance 0 Pain Relevance 0.08
The results also show that for both PGHS1 and PGHS2, flurbiprofen was bound tighter to the initial EI complex than indomethacin; however, the rate of dissociation from EI* was slower for indomethacin than flurbiprofen.
PGHS1 Binding (bound) of
11) Confidence 0.31 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631960 Disease Relevance 0 Pain Relevance 0.20
The KI values associated with the formation of the first reversible complex (EI) for flurbiprofen with PGHS1 and PGHS2 were 0.53 +/- 0. 06 and 0.61 +/- 0.08 microM, respectively; the rate constants for the forward isomerization, k2, into the second reversible complex (EI*) were 0.97 +/- 0.99 and 0.11 +/- 0.01 s-1, respectively, and rates of the reverse isomerization from EI*, k-2, were 0.031 +/- 0.004 and 0.0082 +/- 0.0008 s-1, respectively.
PGHS1 Binding (formation) of
12) Confidence 0.31 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631960 Disease Relevance 0 Pain Relevance 0.10
X-ray crystallographic studies have led to the hypothesis that PGHS-1 and -2 associate with only one face of the membrane bilayer through a novel, monotopic membrane binding domain (MBD) that is comprised of four short, consecutive, amphipathic alpha-helices (helices A-D) that include residues 74-122 in ovine PGHS-1 (oPGHS-1) and residues 59-108 in human PGHS-2 (hPGHS-2).
PGHS-1 Binding (associate) of in face
13) Confidence 0.31 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10551860 Disease Relevance 0.09 Pain Relevance 0.09
Cardiovascular toxicity of selective cyclooxygenase-2 inhibitors
cyclooxygenase Binding (toxicity) of associated with toxicity
14) Confidence 0.30 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 1.00 Pain Relevance 0.35
We report here the preparation and characterization of novel potent iodinated analogs of the NSAIDs indomethacin and suprofen, as well as the refined X-ray crystal structures of their complexes with PGHS-1.
PGHS-1 Binding (complexes) of associated with cinod
15) Confidence 0.30 Published 1996 Journal Biochemistry Section Abstract Doc Link 8652509 Disease Relevance 0.16 Pain Relevance 0.27
Cyclooxygenase 1 (COX-1) and COX-2 are the main targets for NSAIDs.
Cyclooxygenase 1 Binding (targets) of associated with cinod and cox1
16) Confidence 0.29 Published 2008 Journal Kaohsiung J. Med. Sci. Section Abstract Doc Link 18926952 Disease Relevance 0.83 Pain Relevance 0.63
Additionally, other new COX-1-derived proteins called PCOX have been identified that do not make prostaglandins but apparently bind heme and may have other enzymatic properties.
PCOX Neg (not) Binding (bind) of
17) Confidence 0.28 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592545 Disease Relevance 0 Pain Relevance 0.47
A study was made of the nature and mechanism of interaction of voltaren, butadion, analgin, phenacetin and paracetamol with endoperoxide prostaglandin synthetase (PGH-synthetase) of sheep vesicular glands.
PGH-synthetase Binding (interaction) of in vesicular glands associated with paracetamol
18) Confidence 0.28 Published 1984 Journal Farmakol Toksikol Section Abstract Doc Link 6437862 Disease Relevance 0 Pain Relevance 0.15
These differences were associated with less renal cyclooxygenase inhibition by sulindac (reflected by urinary thromboxane B2 and 6-keto PGF1 alpha) than by other NSAIDs.
renal cyclooxygenase Binding (associated) of associated with cinod
19) Confidence 0.26 Published 1986 Journal Lancet Section Abstract Doc Link 2871333 Disease Relevance 0.41 Pain Relevance 0.50
Alternative splicing of cyclooxygenase-1 gene: altered expression in leucocytes from patients with bronchial asthma and association with aspirin-induced 15-HETE release.
cyclooxygenase-1 Binding (association) of in leucocytes associated with asthma and aspirin
20) Confidence 0.26 Published 2007 Journal Allergy Section Title Doc Link 17508966 Disease Relevance 0.72 Pain Relevance 0.46

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