INT91979

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Context Info
Confidence 0.23
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.06
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nkx1-1) neurological system process (Nkx1-1)
Anatomy Link Frequency
knee joints 2
Nkx1-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 3 100.00 Very High Very High Very High
Central grey 9 99.98 Very High Very High Very High
substance P 15 99.26 Very High Very High Very High
Morphine 4 99.04 Very High Very High Very High
antagonist 3 98.82 Very High Very High Very High
agonist 3 98.50 Very High Very High Very High
dorsal root ganglion 107 93.20 High High
Pain 12 92.20 High High
Inflammation 33 90.32 High High
Opioid 1 86.32 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 9 99.98 Very High Very High Very High
Ganglion Cysts 107 93.20 High High
Pain 10 92.20 High High
INFLAMMATION 33 90.32 High High
Aging 1 89.36 High High
Hypoxia 1 88.08 High High
Hyperalgesia 6 75.60 Quite High
Inflammatory Pain 3 73.60 Quite High
Arthritis 30 70.88 Quite High
Arthralgia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microinjection of receptor-selective tachykinin agonists and antagonists into the NTS of urethane-anaesthetized rats suggests that stimulation of NK1 and NK3 receptors increases tidal volume, whereas NK2 and NK3 receptor activation produces a bradypnoea. 3.
Positive_regulation (increases) of Positive_regulation (stimulation) of NK1 associated with antagonist and agonist
1) Confidence 0.23 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11071314 Disease Relevance 0.18 Pain Relevance 0.25
Our results demonstrate that SP injected into the ventrolateral PAG induces an antinociceptive effect via activation of NK-1 receptors.
Positive_regulation (induces) of Positive_regulation (activation) of NK-1 associated with antinociceptive, central grey and substance p
2) Confidence 0.12 Published 2004 Journal Brain Res. Section Abstract Doc Link 14972657 Disease Relevance 0.56 Pain Relevance 1.67
While extracellular soluble mediators from FLS cells from acutely inflamed knee joints are sufficient for the upregulation of NK1 receptors, the presence and most likely direct cellular contacts between FLS cells and sensory neurones are required for the upregulation of B2 and TRPV1 receptors.
Positive_regulation (sufficient) of Positive_regulation (upregulation) of NK1 in knee joints
3) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 1.32 Pain Relevance 1.15

General Comments

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