INT9199

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Context Info
Confidence 0.67
First Reported 1980
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 111
Total Number 116
Disease Relevance 30.99
Pain Relevance 28.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CEBPZ) DNA binding (CEBPZ)
Anatomy Link Frequency
blood 9
brain 7
cortex 5
smooth muscle 4
coronary artery 4
CEBPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 223 100.00 Very High Very High Very High
cva 295 99.98 Very High Very High Very High
agonist 39 99.98 Very High Very High Very High
spinal-cord stimulation 90 99.92 Very High Very High Very High
isoflurane 57 99.82 Very High Very High Very High
cocaine 132 99.80 Very High Very High Very High
halothane 33 99.78 Very High Very High Very High
antagonist 39 99.68 Very High Very High Very High
Thalamus 217 99.64 Very High Very High Very High
adenocard 54 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dyspnea 133 100.00 Very High Very High Very High
Cv General 3 Under Development 207 99.98 Very High Very High Very High
Increased Venous Pressure Under Development 101 99.92 Very High Very High Very High
Hypocapnia 23 99.90 Very High Very High Very High
Panic Disorder 540 99.84 Very High Very High Very High
Hypercapnia 633 99.82 Very High Very High Very High
Phobia 885 99.44 Very High Very High Very High
Hypoventilation 2 99.40 Very High Very High Very High
Anxiety Disorder 1615 98.88 Very High Very High Very High
Coronary Artery Disease 148 98.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in PaCO2 relaxes smooth muscle, dilates cerebral vessels, decreases cerebrovascular resistance, and increases CBF [11].
Positive_regulation (increases) of CBF in smooth muscle
1) Confidence 0.67 Published 2010 Journal International Journal of Pediatrics Section Body Doc Link PMC2913544 Disease Relevance 1.62 Pain Relevance 1.23
Using [133Xe]-SPECT, patients who did not panic after sodium lactate as well as in controls, hemispheric CBF after the infusion was increased (Stewart et al. 1988).
Positive_regulation (increased) of CBF
2) Confidence 0.56 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.73 Pain Relevance 0.15
Yet, patients who experienced a panic attack had an increase of CBF in the occipital lobe.
Positive_regulation (increase) of CBF in lobe associated with panic disorder
3) Confidence 0.56 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.81 Pain Relevance 0.14
Similar elevations of CBF in generalized SAD in the thalamus, midbrain, the lateral, prefrontal and medial cingulum, and the sensomotoric, anterotemporal cortex were stated by investigations by Reiman (1997).
Positive_regulation (elevations) of CBF in prefrontal associated with phobia, midbrain and thalamus
4) Confidence 0.56 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.63 Pain Relevance 0.28
During and after stimulation SAD patients showed an overall increase of subcortical CBF compared to healthy controls who had an elevation of cortical CBF (Tillfors et al. 2002).
Positive_regulation (elevation) of CBF associated with phobia
5) Confidence 0.56 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.63 Pain Relevance 0.27
In the patient group, increased CBF in the right orbitofrontal cortex was detected.
Positive_regulation (increased) of CBF in cortex
6) Confidence 0.56 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.69 Pain Relevance 0.18
Posterior temporal lobe, inferior parietal lobe and cerebellar cortex CBF was decreased bilaterally (Malizia et al. 1998), whereas on study showed increased CBF in the left hippocampus (Bisaga et al. 1998).
Positive_regulation (increased) of CBF in lobe associated with hippocampus
7) Confidence 0.56 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.30 Pain Relevance 0.58
During and after stimulation SAD patients showed an overall increase of subcortical CBF compared to healthy controls who had an elevation of cortical CBF (Tillfors et al. 2002).
Positive_regulation (increase) of CBF associated with phobia
8) Confidence 0.56 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.59 Pain Relevance 0.27
An increased CBF in the right dorsolateral prefrontal cortex, the left inferior temporal cortex and the left hippocampus-amydala complex was detected, additionally a decrease of CBF in the left temporal pole and bilaterally in the cerebellum.
Positive_regulation (increased) of CBF in inferior associated with hippocampus
9) Confidence 0.56 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.60 Pain Relevance 0.33
Nevertheless, in a classical conditioning paradigm using PET, healthy subjects reacted to stimulation with an increase of cerebral blood flow (CBF) in the thalamus, hypothalamus, periaqueductal grey (PAG) and cingulate but not in the amygdalae (Fredrikson et al. 1995; Furmark et al. 1997; Morris et al. 1996).
Positive_regulation (increase) of CBF in hypothalamus associated with periaqueductal grey, positron emission tomography and thalamus
10) Confidence 0.56 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.87 Pain Relevance 0.57
This was not the case in patients who had panicked, but maybe because of induced hyperventilation decreasing CBF.
Neg (not) Positive_regulation (induced) of CBF associated with dyspnea
11) Confidence 0.56 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.73 Pain Relevance 0.15
pCO2 = 22 mmHg) (Reivich 1964; Grubb et al. 1974) or 50% increase in CBF for 5% CO2 inhalation (?
Positive_regulation (increase) of CBF
12) Confidence 0.55 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.42 Pain Relevance 0
In contrast, cerebral arteries are relaxed by increased pCO2, resulting in increased CBF by a direct and/or an indirect effect of CO2 on vascular (endothelium and smooth muscle) and extravascular cells (perivascular nerves, parenchymal neurons, and glia) (Azin 1981; Wang et al. 1994; You et al. 1994).
Positive_regulation (increased) of CBF in endothelium
13) Confidence 0.55 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.13 Pain Relevance 0.08
Taken together, the data reveal that hypercapnia-induced increases in CBF are accompanied by decreases in neuronal activity.
Positive_regulation (increases) of CBF in neuronal associated with hypercapnia
14) Confidence 0.55 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.63 Pain Relevance 0.07
If the pure CBF increase leads to depressed activity, this should also be observed under sensory stimulation.
Positive_regulation (increase) of CBF
15) Confidence 0.55 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.28 Pain Relevance 0.58
At recovery-1, the coronary diameter remained significantly decreased and the CBF remained significantly increased compared to baseline-1 values.
Positive_regulation (increased) of CBF
16) Confidence 0.54 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515431 Disease Relevance 0.23 Pain Relevance 0.13
Our study found that estrogen significantly reduced the degree of coronary artery constriction and significantly increased the CBF, not only at the peak of AP but also in the recovery period compared to baseline.
Positive_regulation (increased) of CBF in coronary artery
17) Confidence 0.54 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515431 Disease Relevance 0.15 Pain Relevance 0
The greater reduction in ET-1 levels was accompanied by both less constriction of the artery and greater increase in CBF at the peak of AP in this setting.
Positive_regulation (increase) of CBF in artery
18) Confidence 0.54 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515431 Disease Relevance 0.16 Pain Relevance 0
Similarly, in the control group, at peak-1 of AP the coronary artery diameter was significantly reduced by 0.42 ± 0.19 mm (p < 0.005) while the CBF was significantly increased by 23.8 ± 16 mL/min (p < 0.05) compared with baseline-1 values (Figure 3 and 4, low level).
Positive_regulation (increased) of CBF in coronary artery
19) Confidence 0.54 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515431 Disease Relevance 0.20 Pain Relevance 0.11
A three-dimensional statistical analysis for CBF activation studies in human brain.
Positive_regulation (activation) of CBF in brain associated with pain
20) Confidence 0.50 Published 1992 Journal J. Cereb. Blood Flow Metab. Section Title Doc Link 1400644 Disease Relevance 0.09 Pain Relevance 0.24

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