INT91991

Context Info Confidence 0.57 First Reported 2000 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 2.55 Pain Relevance 1.67

Anatomy Link Frequency proximal 1 neutrophils 1 IGKV1-22 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 1 99.68 iatrogenic 4 99.54 cINOD 10 98.52 depression 224 92.44 deep brain stimulation 24 88.32 Hippocampus 8 88.08 Inflammatory response 1 79.32 Nucleus accumbens 56 74.96 Dopamine 20 72.32 amygdala 92 61.56

Disease Link Frequency Relevance Heat Bronchopulmonary Dysplasia 4 99.34 Manic Depressive Disorder 32 99.24 Repression 160 98.88 Depression 288 98.70 Cicatrix 4 92.00 Attention Deficit Hyperactivity Disorder 32 86.48 Neurosis 16 83.24 INFLAMMATION 3 82.44 Treatment-resistant Depression (TRD) 16 76.68 Adhesions 1 75.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pretreatment of neutrophils either with Ro 31-8220 and H7, 2 specific inhibitors of protein kinase C (PKC), or with inhibitors of protein tyrosine kinases such as tyrphostin A25 or herbimycin A did not prevent the NSAID-mediated L-selectin shedding.

Negative_regulation (inhibitors) of A25 in neutrophils associated with kinase c and cinod

1) Confidence 0.57 Published 2000 Journal Blood Section Abstract Doc Link 11071659 Disease Relevance 0.31 Pain Relevance 0.85

Postmortem and MRI studies have found glial loss and volume reductions in the PFC in major depressive disorder (MDD) and bipolar disorder (BPD) [209-214] as well as extensive losses in Cg25 and proximal paralimbic regions [163,201,215-221].

Negative_regulation (losses) of Cg25 in proximal associated with manic depressive disorder, depression and bronchopulmonary dysplasia

2) Confidence 0.08 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.74 Pain Relevance 0.27

Spontaneous and treatment-induced remission of symptoms is associated with significantly decreased Cg25 metabolism [51,100,105,110,113,116-119].

Negative_regulation (decreased) of Cg25

3) Confidence 0.06 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.53 Pain Relevance 0.29

If the ego is dependent on repression, we would expect to see decreased activity in the DMN, decreased activity in Cg25 and increased activity in the ON after stimulation.

Negative_regulation (decreased) of Cg25 associated with repression

4) Confidence 0.06 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.46 Pain Relevance 0.13

One possible reason why the effect of Cg25 stimulation appears to have a sustained beneficial effect [253] rather than an iatrogenic one [254] may be that inhibiting activity in Cg25 facilitates the disintegration of a wider network.

Negative_regulation (inhibiting) of Cg25 associated with iatrogenic

5) Confidence 0.06 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.50 Pain Relevance 0.13

General Comments

This test has worked.