INT91994

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2007
Negated 3
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 6.00
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra1)
Anatomy Link Frequency
hippocampus 8
Gfra1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 8 100.00 Very High Very High Very High
electroacupuncture 7 100.00 Very High Very High Very High
fluoxetine 4 99.52 Very High Very High Very High
Desipramine 4 99.22 Very High Very High Very High
Neuropathic pain 16 98.36 Very High Very High Very High
Hippocampus 8 98.36 Very High Very High Very High
Neuropeptide 2 97.84 Very High Very High Very High
Sciatic nerve 2 92.28 High High
Dorsal horn 5 91.84 High High
Eae 4 91.40 High High
Disease Link Frequency Relevance Heat
Convulsion 44 100.00 Very High Very High Very High
Frailty 8 99.84 Very High Very High Very High
Neuropathic Pain 16 98.36 Very High Very High Very High
Nociception 4 93.76 High High
Injury 8 91.40 High High
Hyperalgesia 4 89.44 High High
Ganglion Cysts 5 88.20 High High
Pain 1 70.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using immunohistochemistry, Western blot, and RT-PCR analysis techniques, the present study observed the effects of EA on the expression of GDNF and GDNF family receptor alpha-1 (GFRalpha-1, the high-affinity receptor of GDNF) in neuropathic pain rats.
Regulation (effects) of Gene_expression (expression) of GFRalpha-1 associated with neuropathic pain and electroacupuncture
1) Confidence 0.42 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.84 Pain Relevance 1.23
Chronic (14 days) administration of different classes of antidepressant drugs, including tranylcypromine, desipramine, or fluoxetine, did not significantly affect the GDNF, GFRalpha-1, GFRalpha-2, or RET mRNA levels in CA1, CA3, and dentate gyrus areas of hippocampus.
Neg (not) Regulation (affect) of Gene_expression (levels) of GFRalpha-1 in hippocampus associated with desipramine, antidepressant, hippocampus and fluoxetine
2) Confidence 0.37 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.82 Pain Relevance 0.30
Chronic (14 days) administration of different classes of antidepressant drugs, including tranylcypromine, desipramine, or fluoxetine, did not significantly affect the GDNF, GFRalpha-1, GFRalpha-2, or RET mRNA levels in CA1, CA3, and dentate gyrus areas of hippocampus.
Neg (not) Regulation (affect) of Gene_expression (levels) of GFRalpha-2 in hippocampus associated with desipramine, antidepressant, hippocampus and fluoxetine
3) Confidence 0.37 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.82 Pain Relevance 0.30
The influence of both acute and chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of mRNAs encoding glial cell line-derived neurotrophic factor (GDNF) and its receptors, GFRalpha-1, GFRalpha-2, and c-Ret proto-oncogene (RET) in the rat hippocampus was examined by in situ hybridization.
Spec (examined) Regulation (influence) of Spec (examined) Gene_expression (expression) of GFRalpha-2 in hippocampus associated with antidepressant, convulsion and hippocampus
4) Confidence 0.37 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.57 Pain Relevance 0.10
The influence of both acute and chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of mRNAs encoding glial cell line-derived neurotrophic factor (GDNF) and its receptors, GFRalpha-1, GFRalpha-2, and c-Ret proto-oncogene (RET) in the rat hippocampus was examined by in situ hybridization.
Spec (examined) Regulation (influence) of Spec (examined) Gene_expression (expression) of GFRalpha-1 in hippocampus associated with antidepressant, convulsion and hippocampus
5) Confidence 0.37 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.57 Pain Relevance 0.10
In order to address the role of GDNF and GFRalpha-1 in neuropathic pain, antisense oligodeoxynucleotide (ODN) specifically against GFRalpha-1 was intrathecally administered to result in down-regulation of GFRalpha-1 expression.
Regulation (regulation) of Gene_expression (expression) of GFRalpha-1 associated with neuropathic pain
6) Confidence 0.21 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.33 Pain Relevance 0.94
Nonpeptidergic afferents expressing GFRalpha1 were largely unaffected by SCI.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expressing) of GFRalpha1 associated with frailty
7) Confidence 0.06 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17640046 Disease Relevance 1.04 Pain Relevance 0.62

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