INT91998

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.14
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gfra1)
Anatomy Link Frequency
spinal 4
brainstem 3
dentate gyrus 2
spinal cord 1
Gfra1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 5 100.00 Very High Very High Very High
Eae 5 100.00 Very High Very High Very High
Sciatic nerve 3 100.00 Very High Very High Very High
electroacupuncture 14 99.84 Very High Very High Very High
Thermal hyperalgesia 2 99.12 Very High Very High Very High
Neuropathic pain 21 98.16 Very High Very High Very High
Hippocampus 2 84.36 Quite High
Opioid 2 80.48 Quite High
Analgesic 4 76.80 Quite High
antidepressant 2 76.52 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 100.00 Very High Very High Very High
Injury 7 100.00 Very High Very High Very High
Convulsion 11 99.12 Very High Very High Very High
Hyperalgesia 4 99.12 Very High Very High Very High
Neuropathic Pain 21 98.16 Very High Very High Very High
Substance Withdrawal Syndrome 2 89.20 High High
Nociception 3 86.00 High High
Urological Neuroanatomy 4 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that both protein and mRNA levels of GDNF and GFRalpha-1 in the dorsal root ganglions (DRG), as well as GDNF protein in the spinal dorsal horn, were significantly increased after chronic constriction injury (CCI) of the rats' sciatic nerve and could be further enhanced by EA treatment.
Positive_regulation (enhanced) of Transcription (levels) of GFRalpha-1 in spinal associated with ganglion cysts, eae, spinal dorsal horn, injury, sciatic nerve and electroacupuncture
1) Confidence 0.47 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.84 Pain Relevance 1.30
The results showed that both protein and mRNA levels of GDNF and GFRalpha-1 in the dorsal root ganglions (DRG), as well as GDNF protein in the spinal dorsal horn, were significantly increased after chronic constriction injury (CCI) of the rats' sciatic nerve and could be further enhanced by EA treatment.
Positive_regulation (increased) of Transcription (levels) of GFRalpha-1 in spinal associated with ganglion cysts, eae, spinal dorsal horn, injury, sciatic nerve and electroacupuncture
2) Confidence 0.47 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.84 Pain Relevance 1.28
RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.
Positive_regulation (increased) of Transcription (levels) of GDNFR-beta in brainstem
3) Confidence 0.46 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.17 Pain Relevance 0
Levels of GFRalpha-2 mRNA in the dentate gyrus were also significantly increased by acute and chronic ECS, although this effect was less than that observed for GFRalpha-1.
Positive_regulation (increased) of Transcription (Levels) of GFRalpha-2 in dentate gyrus associated with convulsion
4) Confidence 0.39 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.76 Pain Relevance 0.23
The results showed that both the protein and mRNA levels of GDNF and GFRalpha-1 were significantly increased after CCI, while the thermal hyperalgesia of neuropathic pain rats could be significantly aggravated by antisense ODN treatment, but not by normal saline (NS) or mismatch ODN treatment.
Positive_regulation (increased) of Transcription (levels) of GFRalpha-1 associated with thermal hyperalgesia, eae and neuropathic pain
5) Confidence 0.36 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.35 Pain Relevance 1.05
RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.
Positive_regulation (increased) of in spinal cord Transcription (levels) of GDNFR-beta in brainstem
6) Confidence 0.16 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.17 Pain Relevance 0

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