INT91999

Context Info Confidence 0.67 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 4.67 Pain Relevance 2.45

plasma membrane (Gfra1)

Anatomy Link Frequency spinal cord 2 brainstem 2 internal 2 spinal 1 dentate gyrus 1 Gfra1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Eae 4 98.56 Thermal hyperalgesia 2 97.96 Neuropathic pain 14 97.88 spinal dorsal horn 3 97.28 Sciatic nerve 2 93.20 electroacupuncture 7 92.76 Hippocampus 2 84.36 Opioid 1 80.48 Analgesic 2 76.80 antidepressant 2 76.52

Disease Link Frequency Relevance Heat Ganglion Cysts 5 99.20 Substance Withdrawal Syndrome 6 98.64 Injury 8 98.56 Hyperalgesia 4 97.96 Neuropathic Pain 14 97.88 Convulsion 11 96.72 Urological Neuroanatomy 12 93.28 Acid Base Imbalance 68 92.76 Chronic Renal Failure 64 89.92 Nociception 2 86.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results showed that both protein and mRNA levels of GDNF and GFRalpha-1 in the dorsal root ganglions (DRG), as well as GDNF protein in the spinal dorsal horn, were significantly increased after chronic constriction injury (CCI) of the rats' sciatic nerve and could be further enhanced by EA treatment.

Transcription (levels) of GFRalpha-1 in spinal associated with ganglion cysts, eae, spinal dorsal horn, injury, sciatic nerve and electroacupuncture

1) Confidence 0.67 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.83 Pain Relevance 1.24

RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.

Transcription (levels) of GDNFR-alpha in brainstem

2) Confidence 0.53 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.17 Pain Relevance 0

METHODS: The levels of GDNF, GDNFR-alpha and GDNFR-beta mRNA were assayed by reverse transcription polymerase chain reaction (RT-PCR) with the beta-actin mRNA as an internal control.

Transcription (levels) of GDNFR-beta in internal

3) Confidence 0.53 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.19 Pain Relevance 0

METHODS: The levels of GDNF, GDNFR-alpha and GDNFR-beta mRNA were assayed by reverse transcription polymerase chain reaction (RT-PCR) with the beta-actin mRNA as an internal control.

Transcription (levels) of GDNFR-alpha in internal

4) Confidence 0.53 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.19 Pain Relevance 0

RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.

Transcription (levels) of GDNFR-beta in brainstem

5) Confidence 0.53 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.17 Pain Relevance 0

Levels of GFRalpha-2 mRNA in the dentate gyrus were also significantly increased by acute and chronic ECS, although this effect was less than that observed for GFRalpha-1.

Transcription (Levels) of GFRalpha-2 in dentate gyrus associated with convulsion

6) Confidence 0.44 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.75 Pain Relevance 0.20

The results showed that both the protein and mRNA levels of GDNF and GFRalpha-1 were significantly increased after CCI, while the thermal hyperalgesia of neuropathic pain rats could be significantly aggravated by antisense ODN treatment, but not by normal saline (NS) or mismatch ODN treatment.

Transcription (levels) of GFRalpha-1 associated with thermal hyperalgesia, eae and neuropathic pain

7) Confidence 0.41 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.34 Pain Relevance 1.01

RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.

Transcription (levels) of GDNFR-beta in spinal cord

8) Confidence 0.18 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.17 Pain Relevance 0

RESULTS: The GDNF mRNA levels were increased, and GDNFR-alpha and GDNFR-beta mRNA levels was slightly increased in the spinal cord and brainstem during morphine dependence.

Transcription (levels) of GDNFR-alpha in spinal cord

9) Confidence 0.18 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.17 Pain Relevance 0

In general, the severity of the hypobicarbonatemia correlates with the level of GFR, with the serum [HCO3?]

Transcription (level) of GFR

10) Confidence 0.03 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2991191 Disease Relevance 0.67 Pain Relevance 0

General Comments

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