INT920

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Context Info
Confidence 0.81
First Reported 1973
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 223
Total Number 225
Disease Relevance 42.25
Pain Relevance 78.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
pituitary 13
follicle 6
gonadal 6
hypothalamus 6
brain 4
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 641 99.96 Very High Very High Very High
opiate 176 99.92 Very High Very High Very High
Endogenous opioid 160 99.92 Very High Very High Very High
Dopamine 51 99.92 Very High Very High Very High
antagonist 975 99.88 Very High Very High Very High
Opioid 169 99.76 Very High Very High Very High
fluoxetine 22 99.64 Very High Very High Very High
Dismenorea 10 99.60 Very High Very High Very High
Enkephalin 28 99.56 Very High Very High Very High
Delta opioid receptors 6 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 340 99.92 Very High Very High Very High
Polycystic Ovary Syndrome 327 99.84 Very High Very High Very High
Adenoma 24 99.76 Very High Very High Very High
Endometriosis (extended) 331 99.64 Very High Very High Very High
Reprotox - General 1 228 99.60 Very High Very High Very High
Lifespan 21 99.60 Very High Very High Very High
Hypoglycemia 35 99.54 Very High Very High Very High
Disease 252 98.96 Very High Very High Very High
Galactorrhea 41 98.94 Very High Very High Very High
INFLAMMATION 68 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioid control of LH secretion in humans: menstrual cycle, menopause and aging reduce effect of naloxone but not of morphine.
Localization (secretion) of LH associated with aging, endometriosis (extended), narcan, opioid and morphine
1) Confidence 0.81 Published 1986 Journal Life Sci. Section Title Doc Link 3086650 Disease Relevance 0.20 Pain Relevance 0.83
A number of studies have been made on the role played by endogenous opioid peptides in the secretion of LH in humans.
Localization (secretion) of LH associated with endogenous opioid
2) Confidence 0.81 Published 1986 Journal Life Sci. Section Abstract Doc Link 3086650 Disease Relevance 0.15 Pain Relevance 0.63
These results indicate that in humans there is a change in the activity of the opioids regulating LH secretion during the menstrual cycle, after menopause and in aged men and that these may be studied by the use of naloxone.
Localization (secretion) of LH associated with endometriosis (extended), narcan and opioid
3) Confidence 0.81 Published 1986 Journal Life Sci. Section Abstract Doc Link 3086650 Disease Relevance 0.25 Pain Relevance 0.90
To further evaluate the role exerted by endogenous opioids on LH secretion a naloxone challenge (0.08 mg/Kg b.w. i.v.) was performed in 23 healthy children at different stages of puberty, in 5 adolescents in different period of menstrual cycle, in 3 case of idiopathic precocious puberty (PP), in 7 cases of delayed puberty (DP), in 4 females affected by hypogonadotropic hypogonadism (HH) and in 6 patients affected by polycystic ovary disease (PCOD).
Localization (secretion) of LH in ovary associated with delayed puberty, reprotox - general 3, precocious puberty, hypogonadotropic hypogonadism, narcan and endogenous opioid
4) Confidence 0.81 Published 1986 Journal Acta Endocrinol Suppl (Copenh) Section Abstract Doc Link 3465161 Disease Relevance 0.94 Pain Relevance 0.29
Endogenous opioid inhibitory tone on LH secretion in normal puberty and in several pubertal disturbances.
Localization (secretion) of LH associated with endogenous opioid
5) Confidence 0.81 Published 1986 Journal Acta Endocrinol Suppl (Copenh) Section Title Doc Link 3465161 Disease Relevance 0.96 Pain Relevance 0.49
These data indicate that the central opioid system regulating LH secretion in humans is active only at more advanced stages of puberty and it does not seem to play a role in the beginning of sexual maturation.
Localization (secretion) of LH associated with opioid
6) Confidence 0.81 Published 1986 Journal Acta Endocrinol Suppl (Copenh) Section Abstract Doc Link 3465161 Disease Relevance 1.03 Pain Relevance 0.45
To determine whether antidopaminergic drug administration may modify endogenous opioid activity at the hypothalamic-pituitary level, the effects of naloxone infusion (1.6 mg/h for 4 h) on LH secretion were studied in six postmenopausal women before and after administration of the potent antidopaminergic drug veralipride for 20 days.
Localization (secretion) of LH in pituitary associated with narcan and endogenous opioid
7) Confidence 0.81 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2834413 Disease Relevance 0 Pain Relevance 0.26
Before veralipride administration, the naloxone infusion did not alter LH secretion.
Localization (secretion) of LH associated with narcan
8) Confidence 0.81 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2834413 Disease Relevance 0 Pain Relevance 0.39
An important role for gonadal steroids on the opiatergic inhibitory tone of LH secretion in man is suggested.
Localization (secretion) of LH in gonadal
9) Confidence 0.81 Published 1984 Journal Horm. Metab. Res. Section Abstract Doc Link 6425183 Disease Relevance 0 Pain Relevance 0.30
These findings suggest that endogenous opioid peptides may mediate the inhibitory effect exerted by chronic antidopaminergic drug administration on LH secretion in humans.
Localization (secretion) of LH associated with endogenous opioid
10) Confidence 0.81 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2834413 Disease Relevance 0 Pain Relevance 0.40
The effects of sulpiride and naloxone on the changes in LH secretion induced by a metenkephalin analog (D-Ala2-MePhe4-Met-(o)-ol-Enkephalin, FK 33824, Sandoz, Basel, Switzerland) (DAMME) and dopamine infusion in four castrated men (21 to 25 years of age) were studied.
Localization (secretion) of LH associated with dopamine, narcan and enkephalin
11) Confidence 0.80 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.51
These findings confirm that central dopaminergic and opiatergic systems play a role in the control of LH secretion; the data also exclude any interaction between these systems in regulating LH secretion.
Localization (secretion) of LH
12) Confidence 0.80 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.47
Moreover, in these subjects naloxone reduced the inhibitory effects induced by DAMME but did not change the inhibitory effect of dopamine on LH secretion.
Localization (secretion) of LH associated with dopamine and narcan
13) Confidence 0.80 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.50
The aim of this study was to examine the role of the central dopaminergic system in the mechanisms by which opioid peptides exert their influence on luteinizing hormone (LH) secretion in man.
Localization (secretion) of LH associated with opioid
14) Confidence 0.80 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.49
These findings confirm that central dopaminergic and opiatergic systems play a role in the control of LH secretion; the data also exclude any interaction between these systems in regulating LH secretion.
Localization (secretion) of LH
15) Confidence 0.80 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 4054321 Disease Relevance 0 Pain Relevance 0.46
In contrast to the effects of short-term opioid blockade on LH pulsatile release during the luteal phase, the effects of chronic opioid antagonism on LH release may be transient and may not persist throughout the entire luteal phase, suggesting desensitization of the opiate receptors.


Localization (release) of LH
16) Confidence 0.80 Published 1998 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 9861326 Disease Relevance 0 Pain Relevance 0
Five normal men underwent repetitive (every 20 min) venous sampling for 8 h to characterize episodic LH release quantitatively under basal conditions and after the administration of naltrexone, a potent opiate receptor antagonist which stimulates puslatile LH release.
Localization (release) of LH associated with antagonist and opiate
17) Confidence 0.80 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.34
We conclude that in the doses used, phenoxybenzamine and alpha-methyldopa do not alter spontaneous or opiate-modulated episodic LH release in normal men.
Localization (release) of LH associated with opiate
18) Confidence 0.80 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.28
We tested the excitatory influence of brain noradrenergic systems on pulsatile LH secretion in normal men by administering phenoxybenzamine (an irreversible, preferentially postsynaptic, alpha 1-receptor blocker) or alpha-methyldopa (an inhibitor of brain adrenergic transmission).
Localization (secretion) of LH in brain
19) Confidence 0.80 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.31
In addition, the administration of adrenergic inhibitors did not impede the capacity of naltrexone to significantly augment pulsatile LH secretion in these subjects.
Localization (secretion) of LH
20) Confidence 0.80 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6313736 Disease Relevance 0 Pain Relevance 0.30

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