INT92001

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 6.62
Pain Relevance 6.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
neurons 4
hippocampus 4
neuronal 2
sensory neurons 2
brain 2
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 43 100.00 Very High Very High Very High
electroacupuncture 16 100.00 Very High Very High Very High
Morphine 7 100.00 Very High Very High Very High
withdrawal 5 100.00 Very High Very High Very High
antidepressant 4 100.00 Very High Very High Very High
Sciatic nerve 4 99.92 Very High Very High Very High
fluoxetine 2 99.52 Very High Very High Very High
Locus ceruleus 6 99.48 Very High Very High Very High
Desipramine 2 99.22 Very High Very High Very High
Inflammation 17 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 22 100.00 Very High Very High Very High
Opiate Addiction 2 100.00 Very High Very High Very High
Tooth Injuries 2 99.84 Very High Very High Very High
Injury 28 99.08 Very High Very High Very High
INFLAMMATION 17 99.04 Very High Very High Very High
Neuropathic Pain 18 96.92 Very High Very High Very High
Pain 8 96.12 Very High Very High Very High
Hyperalgesia 4 95.32 Very High Very High Very High
Brain Ischemia 8 95.28 Very High Very High Very High
Nociception 4 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also studied the dynamic changes of GDNF expression in rats during chronic inflammation using injection of complete Freund's adjuvant as a model of chronic pain.
Regulation (changes) of Gene_expression (expression) of GDNF associated with inflammation and lasting pain
1) Confidence 0.62 Published 2003 Journal Neuroscience Section Abstract Doc Link 12617957 Disease Relevance 0.97 Pain Relevance 1.02
Such neuronal survival was related to in vivo mRNA up regulation as well as expression of BDNF and GDNF.
Regulation (regulation) of Gene_expression (expression) of GDNF in neuronal
2) Confidence 0.44 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19049875 Disease Relevance 0 Pain Relevance 0.04
Using immunohistochemistry, Western blot, and RT-PCR analysis techniques, the present study observed the effects of EA on the expression of GDNF and GDNF family receptor alpha-1 (GFRalpha-1, the high-affinity receptor of GDNF) in neuropathic pain rats.
Regulation (effects) of Gene_expression (expression) of GDNF associated with neuropathic pain and electroacupuncture
3) Confidence 0.43 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.83 Pain Relevance 1.21
Using immunohistochemistry, Western blot, and RT-PCR analysis techniques, the present study observed the effects of EA on the expression of GDNF and GDNF family receptor alpha-1 (GFRalpha-1, the high-affinity receptor of GDNF) in neuropathic pain rats.
Regulation (effects) of Gene_expression (expression) of GDNF associated with neuropathic pain and electroacupuncture
4) Confidence 0.43 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.84 Pain Relevance 1.22
The present study was undertaken to determine whether the GDNF receptor, GFRalpha-1, is expressed by pulpal afferents, and, further, to determine whether tooth injury evokes changes in expression of the GDNF and NGF receptors among pulpal afferents.
Spec (whether) Regulation (changes) of Gene_expression (expression) of GDNF in tooth associated with tooth injuries
5) Confidence 0.41 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16444814 Disease Relevance 0.18 Pain Relevance 0.26
For sensory neurons, increased levels of NGF and GDNF do not affect the number of regenerated neurons 1 cm distal to a lesion at 4 weeks post-lesion but do cause changes in the expression of markers for different populations of nociceptive neurons.
Neg (not) Regulation (affect) of Gene_expression (levels) of GDNF in sensory neurons associated with nociception and nerve growth factor
6) Confidence 0.39 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973572 Disease Relevance 0.25 Pain Relevance 0.25
Accompanied by the behavioral changes, expression of GDNF decreased in the dorsal root ganglia (DRGs) and the sciatic nerve on the injured side on the fourteenth day after the surgery.
Regulation (Accompanied) of Gene_expression (expression) of GDNF in DRGs associated with sciatic nerve
7) Confidence 0.38 Published 2003 Journal J. Med. Dent. Sci. Section Abstract Doc Link 12715924 Disease Relevance 0.55 Pain Relevance 0.71
Chronic (14 days) administration of different classes of antidepressant drugs, including tranylcypromine, desipramine, or fluoxetine, did not significantly affect the GDNF, GFRalpha-1, GFRalpha-2, or RET mRNA levels in CA1, CA3, and dentate gyrus areas of hippocampus.
Neg (not) Regulation (affect) of Gene_expression (levels) of GDNF in hippocampus associated with desipramine, antidepressant, hippocampus and fluoxetine
8) Confidence 0.37 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.82 Pain Relevance 0.30
The influence of both acute and chronic electroconvulsive seizure (ECS) or antidepressant drug treatments on expression of mRNAs encoding glial cell line-derived neurotrophic factor (GDNF) and its receptors, GFRalpha-1, GFRalpha-2, and c-Ret proto-oncogene (RET) in the rat hippocampus was examined by in situ hybridization.
Spec (examined) Regulation (influence) of Spec (examined) Gene_expression (expression) of GDNF in hippocampus associated with antidepressant, convulsion and hippocampus
9) Confidence 0.32 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.56 Pain Relevance 0.10
CONCLUSION: EA can regulate expression of GDNF in local dermal tissue of the inflammatory focus in the AA rat, so as to exert the anti-inflammatory and analgesic effects.


Regulation (regulate) of Gene_expression (expression) of GDNF
10) Confidence 0.24 Published 2006 Journal Zhongguo Zhen Jiu Section Body Doc Link 16813188 Disease Relevance 0 Pain Relevance 0
The antisense approach and immunohistochemistry were used to study the effects of different muscarinic receptor (M) subtypes and glial cell derived neurotrophic factor (GDNF) on the scores of morphine-withdrawal syndrome and the expression of c-Fos in locus coeruleus (LC).
Regulation (effects) of Gene_expression (expression) of GDNF in locus coeruleus associated with locus ceruleus, withdrawal and morphine
11) Confidence 0.20 Published 2005 Journal Shi Yan Sheng Wu Xue Bao Section Abstract Doc Link 16044914 Disease Relevance 0.18 Pain Relevance 0.98
The expressions of GDNF and VEGF in astrocytes of penumbra were significantly up-regulated in the transplantation group as compared with the control group.
Regulation (regulated) of Gene_expression (expressions) of GDNF in astrocytes
12) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909196 Disease Relevance 0.27 Pain Relevance 0.36
Transgene expression of GDNF was detected in both methods, and resulted in rescue of injured neurons.
Regulation (resulted) of Gene_expression (expression) of GDNF in neurons
13) Confidence 0.15 Published 2007 Journal Pharm Res Section Body Doc Link PMC2292496 Disease Relevance 0.33 Pain Relevance 0.03
Transgene expression of GDNF was detected in both methods, and resulted in rescue of injured neurons.
Regulation (detected) of Gene_expression (expression) of GDNF in neurons
14) Confidence 0.15 Published 2007 Journal Pharm Res Section Body Doc Link PMC2292496 Disease Relevance 0.28 Pain Relevance 0.03
The present study showed that the transplantation of HMO6 cells in the ischemic brain induced a significant up-regulation in expression of GDNF and VEGF in ischemic penumbra.
Regulation (regulation) of Gene_expression (expression) of GDNF in brain
15) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909196 Disease Relevance 0.56 Pain Relevance 0.15

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