INT92003

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Context Info
Confidence 0.66
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 5.54
Pain Relevance 7.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
spinal 8
spinal cord 2
astrocytes 2
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 8 100.00 Very High Very High Very High
Sciatic nerve 5 100.00 Very High Very High Very High
Eae 4 100.00 Very High Very High Very High
electroacupuncture 28 99.84 Very High Very High Very High
Endep 17 99.68 Very High Very High Very High
antidepressant 55 99.50 Very High Very High Very High
Neuropathic pain 28 97.88 Very High Very High Very High
Spinal cord 31 97.76 Very High Very High Very High
c fibre 1 95.32 Very High Very High Very High
withdrawal 2 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 33 100.00 Very High Very High Very High
Ganglion Cysts 8 100.00 Very High Very High Very High
Convulsion 11 99.36 Very High Very High Very High
Glioblastoma 4 98.52 Very High Very High Very High
Neuropathic Pain 28 97.88 Very High Very High Very High
Spinal Cord Injury 14 97.76 Very High Very High Very High
Necrosis 1 90.28 High High
Cancer 1 89.92 High High
Nociception 4 86.00 High High
Death 1 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that both protein and mRNA levels of GDNF and GFRalpha-1 in the dorsal root ganglions (DRG), as well as GDNF protein in the spinal dorsal horn, were significantly increased after chronic constriction injury (CCI) of the rats' sciatic nerve and could be further enhanced by EA treatment.
Positive_regulation (increased) of Transcription (levels) of GDNF in spinal associated with ganglion cysts, eae, spinal dorsal horn, injury, sciatic nerve and electroacupuncture
1) Confidence 0.66 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.84 Pain Relevance 1.28
Satake et al. [42] reported GDNF transcription began to increase within 30 min after injury and peaked within 3 h after spinal cord contusion injury.
Positive_regulation (increase) of Transcription (transcription) of GDNF in spinal cord associated with injury and spinal cord
2) Confidence 0.60 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.66 Pain Relevance 0.16
The results showed that both protein and mRNA levels of GDNF and GFRalpha-1 in the dorsal root ganglions (DRG), as well as GDNF protein in the spinal dorsal horn, were significantly increased after chronic constriction injury (CCI) of the rats' sciatic nerve and could be further enhanced by EA treatment.
Positive_regulation (enhanced) of Transcription (levels) of GDNF in spinal associated with ganglion cysts, eae, spinal dorsal horn, injury, sciatic nerve and electroacupuncture
3) Confidence 0.48 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.84 Pain Relevance 1.30
The results showed that both protein and mRNA levels of GDNF and GFRalpha-1 in the dorsal root ganglions (DRG), as well as GDNF protein in the spinal dorsal horn, were significantly increased after chronic constriction injury (CCI) of the rats' sciatic nerve and could be further enhanced by EA treatment.
Positive_regulation (increased) of Transcription (levels) of GDNF in spinal associated with ganglion cysts, eae, spinal dorsal horn, injury, sciatic nerve and electroacupuncture
4) Confidence 0.48 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.84 Pain Relevance 1.28
The results showed that both protein and mRNA levels of GDNF and GFRalpha-1 in the dorsal root ganglions (DRG), as well as GDNF protein in the spinal dorsal horn, were significantly increased after chronic constriction injury (CCI) of the rats' sciatic nerve and could be further enhanced by EA treatment.
Positive_regulation (enhanced) of Transcription (levels) of GDNF in spinal associated with ganglion cysts, eae, spinal dorsal horn, injury, sciatic nerve and electroacupuncture
5) Confidence 0.48 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.84 Pain Relevance 1.30
Here, we demonstrated that long-term use of antidepressant treatment significantly increased GDNF mRNA expression and GDNF release in time- and concentration-dependent manners in rat C6 glioblastoma cells.
Positive_regulation (increased) of Transcription (expression) of GDNF associated with antidepressant and glioblastoma
6) Confidence 0.45 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.17 Pain Relevance 0.51
Amitriptyline treatment also increased GDNF mRNA expression in rat astrocytes.
Positive_regulation (increased) of Transcription (expression) of GDNF in astrocytes associated with endep
7) Confidence 0.45 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.17 Pain Relevance 0.55
Moreover, a significant increase in the expression of mRNA for IL-1beta, GDNF and iNOS were observed 6h following the HFS conditioning (p<0.05, HFS vs. control).
Positive_regulation (increase) of Transcription (expression) of GDNF
8) Confidence 0.43 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19596210 Disease Relevance 0.25 Pain Relevance 0.82
Levels of GDNF and RET mRNAs were not significantly changed following either acute or chronic ECS treatment at the time points examined.
Neg (not) Positive_regulation (changed) of Transcription (Levels) of GDNF associated with convulsion
9) Confidence 0.38 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.87 Pain Relevance 0.28
Figures 2 A, B show that NGF, NT-3, GDNF and BDNF transcription increased continuously over the 14 day cultivation period upon PMA treatment, while bFGF, CNTF and Creb showed a steady decline, but these changes were compensatory modulated by antidepressant drugs (Figure 2C–F).
Positive_regulation (increased) of Transcription (transcription) of GDNF associated with antidepressant
10) Confidence 0.10 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.06 Pain Relevance 0.35

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