INT9205

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Context Info
Confidence 0.44
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 9.90
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DSP) structural molecule activity (DSP) plasma membrane (DSP)
protein binding, bridging (DSP) cytoplasm (DSP)
Anatomy Link Frequency
lateral 1
keratinocyte 1
DSP (Homo sapiens)
Pain Link Frequency Relevance Heat
c fibre 4 97.64 Very High Very High Very High
Pain 85 95.28 Very High Very High Very High
Inflammation 2 94.96 High High
cva 2 64.80 Quite High
dysesthesia 1 60.04 Quite High
cannabis 23 59.04 Quite High
peripheral neuropathy 1 50.00 Quite Low
Neuropathic pain 21 48.28 Quite Low
Kinase C 39 5.00 Very Low Very Low Very Low
qutenza 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 940 100.00 Very High Very High Very High
Neuropathy 89 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 84 100.00 Very High Very High Very High
Adhesions 154 99.84 Very High Very High Very High
Diabetes Mellitus 114 99.30 Very High Very High Very High
Disease 63 99.24 Very High Very High Very High
Cancer 17 98.96 Very High Very High Very High
Lichen 2 97.80 Very High Very High Very High
INFLAMMATION 5 94.96 High High
Autoimmune Disease 17 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 250, 230, and 210 kd antigens comigrated with desmoplakin I, the 230 kd bullous pemphigoid antigen, and desmoplakin II, respectively.
desmoplakin II Binding (comigrated) of
1) Confidence 0.44 Published 1992 Journal J. Am. Acad. Dermatol. Section Body Doc Link 1401305 Disease Relevance 0.13 Pain Relevance 0
On the other hand, because plakophilin 1 is located in the dense inner desmosomal plaque whereas cytokeratin filaments only loop into the outer plaque, it is believed that plakophilin 1 enhances desmoplakin lateral interactions but does not directly associate with cytokeratin filaments in vivo (Hatzfeld 2007; North et al. 1999).
desmoplakin Binding (interactions) of in lateral
2) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.10 Pain Relevance 0
Pemphigus IgG were found to include a plethora of more than 20 different autoantibodies against keratinocyte antigens such as antibodies against Dsg 1, Dsg 4, Dsc 1-3, desmoplakin, plakoglobin and E-cadherin and several other proteins not associated with cell junctions (Amagai et al. 2006; Evangelista et al. 2008; Kljuic et al. 2003; Korman et al. 1989; Nguyen et al. 2000c).
desmoplakin Binding (associated) of in keratinocyte associated with bullous skin disease
3) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.74 Pain Relevance 0
Moreover, plakoglobin phosphorylation was shown to be required for EGFR-induced loss of cell adhesion and to regulate binding of plakoglobin to desmoplakin (Miravet et al. 2003; Yin et al. 2005).
desmoplakin Binding (regulate) of associated with adhesions
4) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.48 Pain Relevance 0
Distinct autoantibodies bind desmoplakin I, desmoplakin II, bullous pemphigoid antigen and an uncharacterized 190 kDa antigen.
desmoplakin II Binding (bind) of associated with bullous skin disease
5) Confidence 0.36 Published 1995 Journal Australas. J. Dermatol. Section Abstract Doc Link 8593111 Disease Relevance 0.92 Pain Relevance 0.13
Distinct autoantibodies bind desmoplakin I, desmoplakin II, bullous pemphigoid antigen and an uncharacterized 190 kDa antigen.
desmoplakin I Binding (bind) of associated with bullous skin disease
6) Confidence 0.36 Published 1995 Journal Australas. J. Dermatol. Section Abstract Doc Link 8593111 Disease Relevance 0.91 Pain Relevance 0.13
HIV-DSP was recognised early in the HIV pandemic [2] and is associated with advanced HIV disease [1] [3].
DSP Binding (associated) of associated with acquired immune deficiency syndrome or hiv infection and disease
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3010990 Disease Relevance 2.20 Pain Relevance 0.17
All these events are listed in the Patrocles database which can be interrogated by species, gene identifier, DSP identifier and chromosomal location.


DSP Binding (interrogated) of
8) Confidence 0.10 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2808989 Disease Relevance 0 Pain Relevance 0
The authors concluded that changes in small fiber health associated with DSP leads to an impairment of mechanoresponsive nocioceptors.
DSP Binding (associated) of associated with neuropathy
9) Confidence 0.09 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2940775 Disease Relevance 1.35 Pain Relevance 0.55
CONCLUSIONS—In this large cohort of type 1 diabetic subjects, we found an independent association between sHSP27 and DSP.
DSP Binding (association) of associated with neuropathy and diabetes mellitus
10) Confidence 0.08 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453614 Disease Relevance 1.03 Pain Relevance 0.05
These patients have autoantibodies that bind to a distinct complex of epidermal proteins, including desmoplakin I (250 kD), major bullous pemphigoid antigen (230 kD), desmoplakin II (210 kD) and a 190-kD and a 170-kD protein, neither of which has yet been further characterized.
desmoplakin Neg (neither) Binding (bind) of associated with bullous skin disease
11) Confidence 0.06 Published 1994 Journal Hautarzt Section Abstract Doc Link 7843961 Disease Relevance 0.98 Pain Relevance 0.09
These patients have autoantibodies that bind to a distinct complex of epidermal proteins, including desmoplakin I (250 kD), major bullous pemphigoid antigen (230 kD), desmoplakin II (210 kD) and a 190-kD and a 170-kD protein, neither of which has yet been further characterized.
desmoplakin Neg (neither) Binding (bind) of associated with bullous skin disease
12) Confidence 0.06 Published 1994 Journal Hautarzt Section Abstract Doc Link 7843961 Disease Relevance 1.05 Pain Relevance 0.09

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