INT92050

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Context Info
Confidence 0.21
First Reported 2000
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 1.91
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CUX1) Golgi apparatus (CUX1) nucleolus (CUX1)
nucleus (CUX1) protein binding, bridging (CUX1) cytoplasm (CUX1)
Anatomy Link Frequency
lung 4
blood 1
CUX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 7 80.12 Quite High
Neuropathic pain 1 60.32 Quite High
cytokine 14 60.28 Quite High
anesthesia 28 51.28 Quite High
Disease Link Frequency Relevance Heat
Stroke 42 99.84 Very High Very High Very High
Adult Respiratory Distress Syndrome 238 99.52 Very High Very High Very High
Barotrauma 14 97.16 Very High Very High Very High
Drug Dependence 14 91.24 High High
Pain 4 80.12 Quite High
Injury 14 76.12 Quite High
Lung Injury 154 72.84 Quite High
Urological Neuroanatomy 1 71.92 Quite High
Right Ventricular Dysfunction 14 64.08 Quite High
Neuropathic Pain 1 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PaO2/FiO2 ratio was therefore used as a criterion to identify the lowest TPP preventing alveolar derecruitment during the stepwise decrease of CDP.
Negative_regulation (decrease) of CDP
1) Confidence 0.21 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.08 Pain Relevance 0
This maneuver is followed by a stepwise reduction of the CDP (2 mbar every 30 minutes up to 4 hours) to maintain alveolar patency.
Negative_regulation (reduction) of CDP
2) Confidence 0.19 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.16 Pain Relevance 0
The 3D topographic maps at the peak activation time (100, 140, 250, and 450 ms) showed clear reduction in the amplitudes and their spatial extent (P4/P100-Fc2/N100, POz/P140-Fc2/N140, Cz/P250, Cz/N460) betweenthe first and the fifth stimulus.
Spec (clear) Negative_regulation (reduction) of P100
3) Confidence 0.18 Published 2000 Journal Brain Topogr Section Abstract Doc Link 11073094 Disease Relevance 0.29 Pain Relevance 0.35
The protocol consists of a fast recruitment maneuver followed by a stepwise decrease of CDP.
Negative_regulation (decrease) of CDP
4) Confidence 0.16 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.10 Pain Relevance 0
The stepwise decrease of CDP allowed the determination of the lowest TPP level necessary to maintain adequate oxygenation.


Negative_regulation (decrease) of CDP
5) Confidence 0.16 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.44 Pain Relevance 0.03
The LVOP comprised a recruitment maneuver with a continuous distending pressure (CDP) of 45 mbar for 2.5 minutes, and a stepwise decrease of the CDP (5 mbar every 5 minute) from 45 to 20 mbar.
Negative_regulation (decrease) of CDP
6) Confidence 0.14 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1751068 Disease Relevance 0 Pain Relevance 0
The fast stepwise reduction of CDP allows the identification of the lowest TPP level required to maintain improvement of oxygenation in each animal.
Negative_regulation (reduction) of CDP
7) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.10 Pain Relevance 0
The protocol for lung volume optimization during HFOV comprised three steps: step 1, a lung recruitment maneuver – setting the initial CDP during ongoing oscillations to 45 mbar (CDP45) for 2.5 minutes; step 2, decrease of the CDP – the CDP was reduced in a stepwise manner by 5 mbar every 5 minutes from 45 mbar to 40 mbar, 35 mbar, 30 mbar, 25 mbar, and 20 mbar (CDP20) with simultaneous measurement of the TPP; and step 3, identification of the optimal TPP – the TPP level necessary to maintain lung recruitment was defined as the TPP necessary to prevent a decrease in the PaO2/FiO2 ratio > 25% compared with the PaO2/FiO2 ratio at CDP45 (that is to say, maximum lung recruitment).


Negative_regulation (decrease) of CDP in lung
8) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0 Pain Relevance 0
The cardiac output and stroke volume decreased at CDP45 (P < 0.05) compared with PCV, whereas the heart rate, mean arterial pressure, and intrathoracic blood volume remained unchanged.
Negative_regulation (decreased) of CDP45 in blood associated with stroke
9) Confidence 0.14 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1751068 Disease Relevance 0.10 Pain Relevance 0
The protocol for lung volume optimization during HFOV comprised three steps: step 1, a lung recruitment maneuver – setting the initial CDP during ongoing oscillations to 45 mbar (CDP45) for 2.5 minutes; step 2, decrease of the CDP – the CDP was reduced in a stepwise manner by 5 mbar every 5 minutes from 45 mbar to 40 mbar, 35 mbar, 30 mbar, 25 mbar, and 20 mbar (CDP20) with simultaneous measurement of the TPP; and step 3, identification of the optimal TPP – the TPP level necessary to maintain lung recruitment was defined as the TPP necessary to prevent a decrease in the PaO2/FiO2 ratio > 25% compared with the PaO2/FiO2 ratio at CDP45 (that is to say, maximum lung recruitment).


Negative_regulation (reduced) of CDP in lung
10) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0 Pain Relevance 0
Hemodynamic variables are presented in Table 1 for the lung recruitment maneuver and in Table 2 for the stepwise decrease of the CDP.
Negative_regulation (decrease) of CDP in lung
11) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0 Pain Relevance 0
The CDP was thereafter reduced in a stepwise fashion of five mbar every five minutes with simultaneous measurement of the TPP.
Negative_regulation (reduced) of CDP
12) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.10 Pain Relevance 0.05
Key messages

• A novel lung optimization procedure in uninterrupted HFOV is presented. • The LVOP consists of a single CDP recruitment maneuver during uninterrupted HFOV, followed by a stepwise decrease of the CDP. • This LVOP allows the determination of the lowest TPP that still maintains adequate pulmonary gas exchange. • This LVOP shows no adverse effects in hemodynamics and oxygenation during its intervention in a porcine lavage ARDS model.


Negative_regulation (decrease) of CDP associated with adult respiratory distress syndrome
13) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.40 Pain Relevance 0
At a CDP of 45 mbar, the SV and CO were decreased and, simultaneously, the cardiac filling pressures (LVEDP, right atrial pressure, and PAOP) were elevated.
Negative_regulation (decreased) of CDP
14) Confidence 0.14 Published 2006 Journal Crit Care Section Body Doc Link PMC1751068 Disease Relevance 0.16 Pain Relevance 0
The TPP level was identified during the decrease in CDP, which assured a change of the PaO2/FIO2 ratio < 25% compared with maximum lung recruitment at CDP of 45 mbar (CDP45).
Negative_regulation (decrease) of CDP in lung
15) Confidence 0.14 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1751068 Disease Relevance 0 Pain Relevance 0

General Comments

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