INT92054

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.93
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
connective tissue 4
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 23 100.00 Very High Very High Very High
metalloproteinase 2 100.00 Very High Very High Very High
Morphine 22 99.98 Very High Very High Very High
Inflammation 9 99.16 Very High Very High Very High
Paracetamol 16 99.04 Very High Very High Very High
fluoxetine 2 96.48 Very High Very High Very High
sSRI 2 96.00 Very High Very High Very High
Antinociceptive 2 95.48 Very High Very High Very High
depression 5 91.76 High High
Inflammatory mediators 4 89.60 High High
Disease Link Frequency Relevance Heat
Necrosis 12 100.00 Very High Very High Very High
Cancer 9 100.00 Very High Very High Very High
INFLAMMATION 16 99.16 Very High Very High Very High
Pressure And Volume Under Development 1 98.04 Very High Very High Very High
Targeted Disruption 9 94.08 High High
Encephalitis 1 93.76 High High
Pancreatitis 6 93.40 High High
Depression 5 91.76 High High
Injury 4 87.60 High High
Hepatotoxicity 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Morphine induced TNF-alpha mRNA expression via dopamine and opioid receptors.
Positive_regulation (induced) of Transcription (expression) of TNF-alpha mRNA
1) Confidence 0.50 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17217924 Disease Relevance 0 Pain Relevance 0
Cerulein treatment increased mRNA expression of several proinflammatory cytokines (TNFalpha, IL-1beta, and IL-6) at 12 h with similar magnitude both in wild-type and PACAP-Tg mice.
Positive_regulation (increased) of Transcription (expression) of TNFalpha associated with cytokine
2) Confidence 0.41 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.93 Pain Relevance 0.27
Morphine enhanced mRNA expression of interleukin (IL)-12 p40 and tumor necrosis factor alpha (TNF-alpha) compared with controls, whereas IL-10 levels were unchanged by drug treatment.
Positive_regulation (enhanced) of Transcription (expression) of TNF-alpha associated with necrosis, cancer and morphine
3) Confidence 0.39 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.28 Pain Relevance 1.07
Morphine enhanced mRNA expression of interleukin (IL)-12 p40 and tumor necrosis factor alpha (TNF-alpha) compared with controls, whereas IL-10 levels were unchanged by drug treatment.
Positive_regulation (enhanced) of Transcription (expression) of tumor necrosis factor alpha associated with necrosis, cancer and morphine
4) Confidence 0.39 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.28 Pain Relevance 1.06
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Positive_regulation (increased) of Transcription (Expression) of tumor necrosis factor-alpha in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
5) Confidence 0.37 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.23 Pain Relevance 0.78
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Positive_regulation (increased) of Transcription (Expression) of TNF-alpha in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
6) Confidence 0.37 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.23 Pain Relevance 0.78
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of Transcription (transcription) of TNF-alpha associated with necrosis and cancer
7) Confidence 0.36 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.53 Pain Relevance 0.24
The results revealed that the mRNA expressions of IL-1beta, IL-6, IFNgamma, TNFalpha, and 5-HTT were higher in the depressed patients than those of the healthy controls.
Positive_regulation (higher) of Transcription (expressions) of TNFalpha
8) Confidence 0.09 Published 2006 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 16616982 Disease Relevance 0.47 Pain Relevance 0.85

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox